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Science 3 April 1987:
Vol. 236. no. 4797, pp. 83 - 88
DOI: 10.1126/science.3453112
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Articles

Science, Vol 236, Issue 4797, 83-88
Copyright © 1987 by American Association for the Advancement of Science

articles

Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein

D Pennica, WJ Kohr, WJ Kuang, D Glaister, BB Aggarwal, EY Chen, and DV Goeddel

The primary structure of human uromodulin, a 616-amino acid, 85-kilodalton glycoprotein with in vitro immunosuppressive properties, was determined through isolation and characterization of complementary DNA and genomic clones. The amino acid sequence encoded by one of the exons of the uromodulin gene has homology to the low-density-lipoprotein receptor and the epidermal growth factor precursor. Northern hybridization analyses demonstrate that uromodulin is synthesized by the kidney. Evidence is provided that uromodulin is identical to the previously characterized Tamm-Horsfall glycoprotein, the most abundant protein in normal human urine.


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