Science 3 April 1987: Vol. 236. no. 4797, pp. 70 - 73 DOI: 10.1126/science.3563490

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Articles

A Novel Splice Variant of GLI1 That Promotes Glioblastoma Cell Migration and Invasion.

H.-W. Lo, H. Zhu, X. Cao, A. Aldrich, and F. Ali-Osman (2009)
Cancer Res. 69, 6790-6798
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GLI1 Is a Direct Transcriptional Target of EWS-FLI1 Oncoprotein.

E. Beauchamp, G. Bulut, O. Abaan, K. Chen, A. Merchant, W. Matsui, Y. Endo, J. S. Rubin, J. Toretsky, and A. Uren (2009)
J. Biol. Chem. 284, 9074-9082
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Hedgehog: functions and mechanisms.

M. Varjosalo and J. Taipale (2008)
Genes & Dev. 22, 2454-2472
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GLI2 Knockdown Using an Antisense Oligonucleotide Induces Apoptosis and Chemosensitizes Cells to Paclitaxel in Androgen-Independent Prostate Cancer.

S. Narita, A. So, S. Ettinger, N. Hayashi, M. Muramaki, L. Fazli, Y. Kim, and M. E. Gleave (2008)
Clin. Cancer Res. 14, 5769-5777
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Polydactyly in Mice Lacking HDAC9/HDRP.

B. E. Morrison and S. R. D'Mello (2008)
Experimental Biology and Medicine 233, 980-988
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Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours.

E. M. Kohler, A. Derungs, G. Daum, J. Behrens, and J. Schneikert (2008)
Hum. Mol. Genet. 17, 1978-1987
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Brain Tumor Stem Cells: Bringing Order to the Chaos of Brain Cancer.

P. B. Dirks (2008)
J. Clin. Oncol. 26, 2916-2924
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Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor-Induced Gliomas.

O. J. Becher, D. Hambardzumyan, E. I. Fomchenko, H. Momota, L. Mainwaring, A.-M. Bleau, A. M. Katz, M. Edgar, A. M. Kenney, C. Cordon-Cardo, et al. (2008)
Cancer Res. 68, 2241-2249
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Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells.

P. B Dirks (2008)
Phil Trans R Soc B 363, 139-152
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Bone Morphogenetic Protein 2 Opposes Shh-mediated Proliferation in Cerebellar Granule Cells through a TIEG-1-based Regulation of Nmyc.

R. Alvarez-Rodriguez, M. Barzi, J. Berenguer, and S. Pons (2007)
J. Biol. Chem. 282, 37170-37180
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Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.

M. Lauth, A. Bergstrom, T. Shimokawa, and R. Toftgard (2007)
PNAS 104, 8455-8460
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The Consensus Coding Sequences of Human Breast and Colorectal Cancers.

T. Sjoblom, S. Jones, L. D. Wood, D. W. Parsons, J. Lin, T. D. Barber, D. Mandelker, R. J. Leary, J. Ptak, N. Silliman, et al. (2006)
Science 314, 268-274
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Squamous Cell Carcinoma Related Oncogene/DCUN1D1 Is Highly Conserved and Activated by Amplification in Squamous Cell Carcinomas.

I. Sarkaria, P. O-charoenrat, S. G. Talbot, P. G. Reddy, I. Ngai, E. Maghami, K. N. Patel, B. Lee, Y. Yonekawa, M. Dudas, et al. (2006)
Cancer Res. 66, 9437-9444
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Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation.

T Akiyoshi, M Nakamura, K Koga, H Nakashima, T Yao, M Tsuneyoshi, M Tanaka, and M Katano (2006)
Gut 55, 991-999
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Nucleo-cytoplasmic distribution of {beta}-catenin is regulated by retention..

E. Krieghoff, J. Behrens, and B. Mayr (2006)
J. Cell Sci. 119, 1453-1463
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Mice Deficient in the Fused Homolog Do Not Exhibit Phenotypes Indicative of Perturbed Hedgehog Signaling during Embryonic Development.

M.-H. Chen, N. Gao, T. Kawakami, and P.-T. Chuang (2005)
Mol. Cell. Biol. 25, 7042-7053
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gli-1 Oncogene Is Highly Expressed in Granulomatous Skin Disorders, Including Sarcoidosis, Granuloma Annulare, and Necrobiosis Lipoidica Diabeticorum.

N. C. Macaron, C. Cohen, S. C. Chen, and J. L. Arbiser (2005)
Arch Dermatol 141, 259-262
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Hedgehog Signaling Promotes Prostate Xenograft Tumor Growth.

L. Fan, C. V. Pepicelli, C. C. Dibble, W. Catbagan, J. L. Zarycki, R. Laciak, J. Gipp, A. Shaw, M. L. G. Lamm, A. Munoz, et al. (2004)
Endocrinology 145, 3961-3970
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Poliovirus receptor CD155-targeted oncolysis of glioma.

M. K. Merrill, G. Bernhardt, J. H. Sampson, C. J. Wikstrand, D. D. Bigner, and M. Gromeier (2004)
Neuro-oncol 6, 208-217
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Activation of the GLI Oncogene through Fusion with the {beta}-Actin Gene (ACTB) in a Group of Distinctive Pericytic Neoplasms: Pericytoma with t(7;12).

A. Dahlen, C. D. M. Fletcher, F. Mertens, J. A. Fletcher, A. R. Perez-Atayde, M. J. Hicks, M. Debiec-Rychter, R. Sciot, J. Wejde, R. Wedin, et al. (2004)
Am. J. Pathol. 164, 1645-1653
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Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway.

C. B. Bai, W. Auerbach, J. S. Lee, D. Stephen, and A. L. Joyner (2003)
Development 129, 4753-4761
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Characterization of the Physical Interaction of Gli Proteins with SUFU Proteins.

M. Dunaeva, P. Michelson, P. Kogerman, and R. Toftgard (2003)
J. Biol. Chem. 278, 5116-5122
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Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors.

A. M. Kenney, M. D. Cole, and D. H. Rowitch (2003)
Development 130, 15-28
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Identification of Glis1, a Novel Gli-related, Kruppel-like Zinc Finger Protein Containing Transactivation and Repressor Functions.

Y.-S. Kim, M. Lewandoski, A. O. Perantoni, S. Kurebayashi, G. Nakanishi, and A. M. Jetten (2002)
J. Biol. Chem. 277, 30901-30913
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FOXM1 Is a Downstream Target of Gli1 in Basal Cell Carcinomas.

M.-T. Teh, S.-T. Wong, G. W. Neill, L. R. Ghali, M. P. Philpott, and A. G. Quinn (2002)
Cancer Res. 62, 4773-4780
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Expression of the Human Poliovirus Receptor/CD155 Gene Is Activated by Sonic Hedgehog.

D. J. Solecki, M. Gromeier, S. Mueller, G. Bernhardt, and E. Wimmer (2002)
J. Biol. Chem. 277, 25697-25702
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Characterization of Glis2, a Novel Gene Encoding a Gli-related, Kruppel-like Transcription Factor with Transactivation and Repressor Functions. ROLES IN KIDNEY DEVELOPMENT AND NEUROGENESIS.

F. Zhang, G. Nakanishi, S. Kurebayashi, K. Yoshino, A. Perantoni, Y.-S. Kim, and A. M. Jetten (2002)
J. Biol. Chem. 277, 10139-10149
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The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis.

N. Dahmane, P. Sanchez, Y. Gitton, V. Palma, T. Sun, M. Beyna, H. Weiner, and A. Ruiz i Altaba (2001)
Development 128, 5201-5212
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GLI1 Localization in the Germinal Epithelial Cells Alternates Between Cytoplasm and Nucleus: Upregulation in Transgenic Mice Blocks Spermatogenesis in Pachytene.

T. L. Kroft, J. Patterson, J. Won Yoon, L. Doglio, D. O. Walterhouse, P. M. Iannaccone, and E. Goldberg (2001)
Biol Reprod 65, 1663-1671
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The hedgehog pathway and basal cell carcinomas.

A. E. Bale and K.-p. Yu (2001)
Hum. Mol. Genet. 10, 757-762
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GLI-2 Modulates Retroviral Gene Expression.

M. J. Smith, S. D. Gitlin, C. M. Browning, B. R. Lane, N. M. Clark, N. Shah, S. Rainier, and D. M. Markovitz (2001)
J. Virol. 75, 2301-2313
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Human GLI-2 Is a Tat Activation Response Element-Independent Tat Cofactor.

C. M. Browning, M. J. Smith, N. M. Clark, B. R. Lane, C. Parada, M. Montano, V. N. KewalRamani, D. R. Littman, M. Essex, R. G. Roeder, et al. (2001)
J. Virol. 75, 2314-2323
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Regulation of Gli Activity by All-trans Retinoic Acid in Mouse Keratinocytes.

P. Goyette, D. Allan, P. Peschard, C. F. Chen, W. Wang, and D. Lohnes (2000)
Cancer Res. 60, 5386-5389
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Comparative genetic patterns of glioblastoma multiforme: Potential diagnostic tool for tumor classification.

R. N. Wiltshire, B.K. A. Rasheed, H. S. Friedman, A. H. Friedman, and S. H. Bigner (2000)
Neuro-oncol 2, 164-173
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The Normal patched Allele Is Expressed in Medulloblastomas from Mice with Heterozygous Germ-Line Mutation of patched.

C. Wetmore, D. E. Eberhart, and T. Curran (2000)
Cancer Res. 60, 2239-2246
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Intragenic Mutation Analysis of the Human Epidermal Growth Factor Receptor (EGFR) Gene in Malignant Human Oral Keratinocytes.

S. Shintani, K. Matsuo, C. C. Crohin, J. McBride, T. Tsuji, R. B. Donoff, M. Posner, R. Todd, and D. T.W. Wong (1999)
Cancer Res. 59, 4142-4147
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The Zinc Finger Protein GLI Induces Cellular Sensitivity to the mTOR Inhibitor Rapamycin.

I. D. Louro, P. McKie-Bell, H. Gosnell, B. C. Brindley, R. P. Bucy, and J. M. Ruppert (1999)
Cell Growth Differ. 10, 503-516
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GLI Gene Expression in Bone and Soft Tissue Sarcomas of Adult Patients Correlates with Tumor Grade.

U. Stein, C. Eder, U. Karsten, W. Haensch, W. Walther, and P. M. Schlag (1999)
Cancer Res. 59, 1890-1895
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Sonic Hedgehog-induced Activation of the Gli1 Promoter Is Mediated by GLI3.

P. Dai, H. Akimaru, Y. Tanaka, T. Maekawa, M. Nakafuku, and S. Ishii (1999)
J. Biol. Chem. 274, 8143-8152
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Gli proteins encode context-dependent positive and negative functions: implications for development and disease.

A Ruiz i Altaba (1999)
Development 126, 3205-3216
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GLI Activates Transcription through a Herpes Simplex Viral Protein 16-Like Activation Domain.

J. W. Yoon, C. Z. Liu, J. T. Yang, R. Swart, P. Iannaccone, and D. Walterhouse (1998)
J. Biol. Chem. 273, 3496-3501
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Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog.

A Ruiz i Altaba (1998)
Development 125, 2203-2212
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Gli1 is a target of Sonic hedgehog that induces ventral neural tube development.

J Lee, K. Platt, P Censullo, and A Ruiz i Altaba (1997)
Development 124, 2537-2552
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A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro.

H Sasaki, C Hui, M Nakafuku, and H Kondoh (1997)
Development 124, 1313-1322
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Control of Cell Growth and Fate by patched Genes.

R.L. Johnson and M.P. Scott (1997)
Cold Spring Harb Symp Quant Biol 62, 205-215
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Cellular Sources of Transforming Growth Factor-Alpha in Human Oral Cancer.

R. Todd, M.Y. Chou, K. Matossian, G.T. Gallagher, R.B. Donoff, and D.T.W. Wong (1991)
Journal of Dental Research 70, 917-923
 |  Abstract »  |  PDF »

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila..

T V Orenic, D C Slusarski, K L Kroll, and R A Holmgren (1990)
Genes & Dev. 4, 1053-1067
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Physical and Functional Interactions between Zic and Gli Proteins.

Y. Koyabu, K. Nakata, K. Mizugishi, J. Aruga, and K. Mikoshiba (2001)
J. Biol. Chem. 276, 6889-6892
 |  Abstract »  |  Full Text »  |  PDF »

Post-transcriptional Regulation of the GLI1 Oncogene by the Expression of Alternative 5' Untranslated Regions.

X.-Q. Wang and J. A Rothnagel (2001)
J. Biol. Chem. 276, 1311-1316
 |  Abstract »  |  Full Text »  |  PDF »

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