Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 March 1987:
Vol. 235. no. 4796, pp. 1638 - 1641
DOI: 10.1126/science.3823907
Prev | Table of Contents | Next

Articles

Science, Vol 235, Issue 4796, 1638-1641
Copyright © 1987 by American Association for the Advancement of Science

articles

Human lipoprotein lipase complementary DNA sequence

KL Wion, TG Kirchgessner, AJ Lusis, MC Schotz, and RM Lawn

Lipoprotein lipase is a key enzyme of lipid metabolism that acts to hydrolyze triglycerides, providing free fatty acids for cells and affecting the maturation of circulating lipoproteins. It has been proposed that the enzyme plays a role in the development of obesity and atherosclerosis. The human enzyme has been difficult to purify and its protein sequence was heretofore undetermined. A complementary DNA for human lipoprotein lipase that codes for a mature protein of 448 amino acids has now been cloned and sequenced. Analysis of the sequence indicates that human lipoprotein lipase, hepatic lipase, and pancreatic lipase are members of a gene family. Two distinct species of lipoprotein lipase messenger RNA that arise from alternative sites of 3'-terminal polyadenylation were detected in several different tissues.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lipoprotein lipase: from gene to obesity.
H. Wang and R. H. Eckel (2009)
Am J Physiol Endocrinol Metab 297, E271-E288
   Abstract »    Full Text »    PDF »
Each Lipase Has a Unique Sensitivity Profile for Organophosphorus Inhibitors.
G. B. Quistad, S. N. Liang, K. J. Fisher, D. K. Nomura, and J. E. Casida (2006)
Toxicol. Sci. 91, 166-172
   Abstract »    Full Text »    PDF »
Role of A Kinase Anchor Proteins in the Tissue-Specific Regulation of Lipoprotein Lipase.
G. Ranganathan, I. Pokrovskaya, S. Ranganathan, and P. A. Kern (2005)
Mol. Endocrinol. 19, 2527-2534
   Abstract »    Full Text »    PDF »
The Lowering of Plasma Lipids following a Weight Reduction Program Is Related to Increased Expression of the LDL Receptor and Lipoprotein Lipase.
M. Patalay, I. E. Lofgren, H. C. Freake, S. I. Koo, and M. L. Fernandez (2005)
J. Nutr. 135, 735-739
   Abstract »    Full Text »    PDF »
A novel method of identifying genetic mutations using an electrochemical DNA array.
J. Wakai, A. Takagi, M. Nakayama, T. Miya, T. Miyahara, T. Iwanaga, S. Takenaka, Y. Ikeda, and M. Amano (2004)
Nucleic Acids Res. 32, e141
   Abstract »    Full Text »    PDF »
Lipoprotein Lipase Affects the Survival and Differentiation of Neural Cells Exposed to Very Low Density Lipoprotein.
E. Paradis, S. Clement, P. Julien, and M. R. Ven Murthy (2003)
J. Biol. Chem. 278, 9698-9705
   Abstract »    Full Text »    PDF »
Sex and Hormonal Status Modulate the Effects of Psyllium on Plasma Lipids and Monocyte Gene Expression in Humans.
S. Vega-Lopez, H. C. Freake, and M. L. Fernandez (2003)
J. Nutr. 133, 67-70
   Abstract »    Full Text »    PDF »
The Translational Regulation of Lipoprotein Lipase by Epinephrine Involves an RNA Binding Complex Including the Catalytic Subunit of Protein Kinase A.
G. Ranganathan, D. Phan, I. D. Pokrovskaya, J. E. McEwen, C. Li, and P. A. Kern (2002)
J. Biol. Chem. 277, 43281-43287
   Abstract »    Full Text »    PDF »
The lipase gene family.
H. Wong and M. C. Schotz (2002)
J. Lipid Res. 43, 993-999
   Abstract »    Full Text »    PDF »
Cooperation between C/EBPalpha TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation.
T. A. Pedersen, E. Kowenz-Leutz, A. Leutz, and C. Nerlov (2001)
Genes & Dev. 15, 3208-3216
   Abstract »    Full Text »    PDF »
Regulation of Lipoprotein Lipase by the Oxysterol Receptors, LXRalpha and LXRbeta.
Y. Zhang, J. J. Repa, K. Gauthier, and D. J. Mangelsdorf (2001)
J. Biol. Chem. 276, 43018-43024
   Abstract »    Full Text »    PDF »
Macrophage-Specific Expression of Human Lipoprotein Lipase Accelerates Atherosclerosis in Transgenic Apolipoprotein E Knockout Mice but Not in C57BL/6 Mice.
K. Wilson, G. L. Fry, D. A. Chappell, C. D. Sigmund, and J. D. Medh (2001)
Arterioscler Thromb Vasc Biol 21, 1809-1815
   Abstract »    Full Text »    PDF »
Novel site in lipoprotein lipase (LPL415;-438) essential for substrate interaction and dimer stability.
T. Keiper, J. G. Schneider, and K. A. Dugi (2001)
J. Lipid Res. 42, 1180-1186
   Abstract »    Full Text »    PDF »
Novel compound heterozygous mutations for lipoprotein lipase deficiency: a G-to-T transversion at the first position of exon 5 causing G154V missense mutation and a 5' splice site mutation of intron 8.
Y. Ikeda, A. Takagi, Y. Nakata, Y. Sera, S. Hyoudou, K. Hamamoto, Y. Nishi, and A. Yamamoto (2001)
J. Lipid Res. 42, 1072-1081
   Abstract »    Full Text »    PDF »
Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice.
H. L. Dichek, S. M. Johnson, H. Akeefe, G. T. Lo, E. Sage, C. E. Yap, and R. W. Mahley (2001)
J. Lipid Res. 42, 201-210
   Abstract »    Full Text »
wo novel mutations in the lipoprotein lipase gene in a family with marked hypertriglyceridemia in heterozygous carriers: potential interaction with the polymorphic marker D1S104 on chromosome 1q21-q23.
B. Hölzl, H. G. Kraft, H. Wiebusch, A. Sandhofer, J. Patsch, F. Sandhofer, and B. Paulweber (2000)
J. Lipid Res. 41, 734-741
   Abstract »    Full Text »
Lipoprotein Lipase Activity and mRNA Are Up-Regulated by Refeeding in Adipose Tissue and Cardiac Muscle of Sheep.
M. Bonnet, C. Leroux, Y. Faulconnier, J.-F. Hocquette, F. Bocquier, P. Martin, and Y. Chilliard (2000)
J. Nutr. 130, 749-756
   Abstract »    Full Text »
Adult Human Mesenchymal Stem Cell Differentiation to the Osteogenic or Adipogenic Lineage Is Regulated by Mitogen-activated Protein Kinase.
R. K. Jaiswal, N. Jaiswal, S. P. Bruder, G. Mbalaviele, D. R. Marshak, and M. F. Pittenger (2000)
J. Biol. Chem. 275, 9645-9652
   Abstract »    Full Text »    PDF »
cld and lec23 are disparate mutations that affect maturation of lipoprotein lipase in the endoplasmic reticulum.
V. Briquet-Laugier, O. Ben-Zeev, A. White, and M. H. Doolittle (1999)
J. Lipid Res. 40, 2044-2058
   Abstract »    Full Text »
Selective Up-regulation of Fatty Acid Uptake by Adipocytes Characterizes Both Genetic and Diet-induced Obesity in Rodents.
P. D. Berk, S.-L. Zhou, C.-L. Kiang, D. D. Stump, X. Fan, and M. W. Bradbury (1999)
J. Biol. Chem. 274, 28626-28631
   Abstract »    Full Text »    PDF »
The Lipoprotein Lipase HindIII Polymorphism: Association with Total Cholesterol and LDL-Cholesterol, but not with HDL and Triglycerides in 342 Females.
I. Larson, M. M. Hoffmann, J. M. Ordovas, E. J. Schaefer, W. Marz, and J. Kreuzer (1999)
Clin. Chem. 45, 963-968
   Abstract »    Full Text »    PDF »
Role of Protein Kinase C in the Translational Regulation of Lipoprotein Lipase in Adipocytes.
G. Ranganathan, R. Kaakaji, and P. A. Kern (1999)
J. Biol. Chem. 274, 9122-9127
   Abstract »    Full Text »    PDF »
Association of lipoprotein lipase gene polymorphisms with coronary artery disease.
J. L. Anderson, G. J. King, T. L. Bair, S. P. Elmer, J. B. Muhlestein, J. Habashi, L. Mixson, and J. F. Carlquist (1999)
J. Am. Coll. Cardiol. 33, 1013-1020
   Abstract »    Full Text »    PDF »
Detailed characterization of the binding site of the lipoprotein lipase-specific monoclonal antibody 5D2.
S.-F. Chang, B. Reich, J. D. Brunzell, and H. Will (1998)
J. Lipid Res. 39, 2350-2359
   Abstract »    Full Text »
A novel amplicon at 8p22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma.
S. J. Hughes, T. W. Glover, X.-X. Zhu, R. Kuick, D. Thoraval, M. B. Orringer, D. G. Beer, and S. Hanash (1998)
PNAS 95, 12410-12415
   Abstract »    Full Text »    PDF »
Cloning of a Phosphatidic Acid-preferring Phospholipase A1 from Bovine Testis.
H. N. Higgs, M. H. Han, G. E. Johnson, and J. A. Glomset (1998)
J. Biol. Chem. 273, 5468-5477
   Abstract »    Full Text »    PDF »
The Ser447–Ter mutation of the lipoprotein lipase gene relates to variability of serum lipid and lipoprotein levels in monozygotic twins1.
J. A. Thorn, E. W. A. Needham, R. K. Mattu, J. Stocks, and D. J. Galton (1998)
J. Lipid Res. 39, 437-441
   Abstract »    Full Text »
Acquisition of Secretion of Transforming Growth Factor-beta 1 Leads to Autonomous Suppression of Scavenger Receptor Activity in a Monocyte-Macrophage Cell Line, THP-1.
N. Nishimura, M. Harada-Shiba, S. Tajima, R. Sugano, T. Yamamura, Q. Z. Qiang, and A. Yamamoto (1998)
J. Biol. Chem. 273, 1562-1567
   Abstract »    Full Text »    PDF »
Induced Mutant Mice Expressing Lipoprotein Lipase Exclusively in Muscle Have Subnormal Triglycerides yet Reduced High Density Lipoprotein Cholesterol Levels in Plasma.
S. Levak-Frank, P. H. Weinstock, T. Hayek, R. Verdery, W. Hofmann, R. Ramakrishnan, W. Sattler, J. L. Breslow, and R. Zechner (1997)
J. Biol. Chem. 272, 17182-17190
   Abstract »    Full Text »    PDF »
Therapeutic Response to Medium-Chain Triglycerides and {omega}-3 Fatty Acids in a Patient With the Familial Chylomicronemia Syndrome.
M. Rouis, K. A. Dugi, L. Previato, A. P. Patterson, J. D. Brunzell, H. B. Brewer, and S. Santamarina-Fojo (1997)
Arterioscler Thromb Vasc Biol 17, 1400-1406
   Abstract »    Full Text »
A molecular biology-based approach to resolve the subunit orientation of lipoprotein lipase.
H. Wong, D. Yang, J. S. Hill, R. C. Davis, J. Nikazy, and M. C. Schotz (1997)
PNAS 94, 5594-5598
   Abstract »    Full Text »    PDF »
Uptake of Long Chain Free Fatty Acids Is Selectively Up-regulated in Adipocytes of Zucker Rats with Genetic Obesity and Non-insulin-dependent Diabetes Mellitus.
P. D. Berk, S.-L. Zhou, C.-L. Kiang, D. Stump, M. Bradbury, and L. M. Isola (1997)
J. Biol. Chem. 272, 8830-8835
   Abstract »    Full Text »    PDF »
Translational Regulation of Lipoprotein Lipase by Epinephrine Involves a Trans-acting Binding Protein Interacting with the 3' Untranslated Region.
G. Ranganathan, D. Vu, and P. A. Kern (1997)
J. Biol. Chem. 272, 2515-2519
   Abstract »    Full Text »    PDF »
Analysis of Protein Structure-Function in Vivo. ADENOVIRUS-MEDIATED TRANSFER OF LIPASE LID MUTANTS IN HEPATIC LIPASE-DEFICIENT MICE.
J. Kobayashi, D. Applebaum-Bowden, K. A. Dugi, D. R. Brown, V. S. Kashyap, C. Parrott, C. Duarte, N. Maeda, and S. Santamarina-Fojo (1996)
J. Biol. Chem. 271, 26296-26301
   Abstract »    Full Text »    PDF »
Expression and Regulation of the Lipoprotein Lipase Gene in Human Adrenal Cortex.
B. Staels, G. Martin, M. Martinez, C. Albert, J. Peinado-Onsurbe, R. Saladin, D. W. Hum, M. Reina, S. Vilaro, and J. Auwerx (1996)
J. Biol. Chem. 271, 17425-17432
   Abstract »    Full Text »    PDF »
Regulation of Very-Low-Density Lipoprotein Receptor in Hypertrophic Rat Heart.
H. Masuzaki, H. Jingami, N. Matsuoka, O. Nakagawa, Y. Ogawa, M. Mizuno, Y. Yoshimasa, T. Yamamoto, and K. Nakao (1996)
Circ. Res. 78, 8-14
   Abstract »    Full Text »
Chicken Lecithin-Cholesterol Acyltransferase.
E. Hengstschläger-Ottnad, K. Kuchler, and W. J. Schneider (1995)
J. Biol. Chem. 270, 26139-26145
   Abstract »    Full Text »    PDF »
Human Hepatic and Lipoprotein Lipase: The Loop Covering the Catalytic Site Mediates Lipase Substrate Specificity.
K. A. Dugi, H.én L. Dichek, and S. Santamarina-Fojo (1995)
J. Biol. Chem. 270, 25396-25401
   Abstract »    Full Text »    PDF »
Polymorphisms in the Lipoprotein Lipase Gene and Their Associations With Plasma Lipid Concentrations in 40-Year-Old Danish Men.
C. Gerdes, L. U. Gerdes, P. S. Hansen, and O. Faergeman (1995)
Circulation 92, 1765-1769
   Abstract »    Full Text »
Tissue-specific Expression of Human Lipoprotein Lipase.
G. Ranganathan, A. Yukht, M. Saghizadeh, R. B. Simsolo, A. Pauer, and P. A. Kern (1995)
J. Biol. Chem. 270, 7149-7155
   Abstract »    Full Text »    PDF »
Perturbation of developmental gene expression in rat liver by fibric acid derivatives: lipoprotein lipase and alpha-fetoprotein as models.
B Staels and J Auwerx (1992)
Development 115, 1035-1043
   Abstract »    PDF »
Insulin-stimulated release of lipoprotein lipase by metabolism of its phosphatidylinositol anchor.
B. Chan, M. Lisanti, E Rodriguez-Boulan, and A. Saltiel (1988)
Science 241, 1670-1672
   Abstract »    PDF »
The Translational Regulation of Lipoprotein Lipase in Diabetic Rats Involves the 3'-Untranslated Region of the Lipoprotein Lipase mRNA.
G. Ranganathan, C. Li, and P. A. Kern (2000)
J. Biol. Chem. 275, 40986-40991
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)