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Science 27 March 1987:
Vol. 235. no. 4796, pp. 1616 - 1622
DOI: 10.1126/science.3029872
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Articles

Science, Vol 235, Issue 4796, 1616-1622
Copyright © 1987 by American Association for the Advancement of Science

articles

Variable number of tandem repeat (VNTR) markers for human gene mapping

Y Nakamura, M Leppert, P O'Connell, R Wolff, T Holm, M Culver, C Martin, E Fujimoto, M Hoff, E Kumlin, and al. et

A large collection of good genetic markers is needed to map the genes that cause human genetic diseases. Although nearly 400 polymorphic DNA markers for human chromosomes have been described, the majority have only two alleles and are thus uninformative for analysis of genetic linkage in many families. A few known marker systems, however, detect loci that respond to restriction enzyme cleavage by producing a fragment that can have many different lengths. This polymorphism is due to variation in the number of tandem repeats of a short DNA sequence. Because most individuals will be heterozygous at such loci, these markers will provide linkage information in almost all families. Ten oligomeric sequences derived from the tandem repeat regions of the myoglobin gene, the zeta-globin pseudogene, the insulin gene, and the X-gene region of hepatitis B virus, were used to develop a series of single-copy probes. These probes revealed new, highly polymorphic genetic loci whose allele sizes reflected variation in the number of tandem repeats.


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Science 244, 207-211
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DNA diagnostics--molecular techniques and automation.
U Landegren, R Kaiser, C. Caskey, and L Hood (1988)
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Concerted nonsyntenic allelic loss in human colorectal carcinoma.
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A DNA segment encoding two genes very tightly linked to Huntington's disease.
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Clonal analysis of human colorectal tumors.
E. Fearon, Hamilton SR, and B Vogelstein (1987)
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Use of repetitive sequences to identify DNA polymorphisms linked to regA, a developmentally important locus in Volvox..
J F Harper, K S Huson, and D L Kirk (1987)
Genes & Dev. 1, 573-584
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Disease diagnosis by recombinant DNA methods.
C. Caskey (1987)
Science 236, 1223-1229
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Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17.
D Barker, E Wright, K Nguyen, L Cannon, P Fain, D Goldgar, D. Bishop, J Carey, B Baty, J Kivlin, et al. (1987)
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