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Science 20 March 1987:
Vol. 235. no. 4795, pp. 1514 - 1517
DOI: 10.1126/science.3547652
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Articles

Science, Vol 235, Issue 4795, 1514-1517
Copyright © 1987 by American Association for the Advancement of Science

articles

Two mammalian genes transcribed from opposite strands of the same DNA locus

JP Adelman, CT Bond, J Douglass, and E Herbert

This report describes the characterization of a genomic locus in the rat that encodes overlapping genes occupying both strands of the same piece of DNA. One gene (strand) encodes gonadotropin-releasing hormone (GnRH). A second gene, SH, is transcribed from the other DNA strand to produce RNA of undefined function. The RNAs transcribed from each DNA strand are spliced and polyadenylated, and share significant exon domains. GnRH is expressed in the central nervous system while SH transcripts are present in the heart. Thus, the genome of a mammalian organism encodes two distinct genes by using both strands of the same DNA.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)