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Science 20 March 1987:
Vol. 235. no. 4795, pp. 1504 - 1508
DOI: 10.1126/science.3493529
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Articles

Science, Vol 235, Issue 4795, 1504-1508
Copyright © 1987 by American Association for the Advancement of Science

articles

Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein

GG Wong, PA Temple, AC Leary, JS Witek-Giannotti, YC Yang, AB Ciarletta, M Chung, P Murtha, R Kriz, RJ Kaufman, and al. et

A 4-kilobase complementary DNA (cDNA) encoding human macrophage-specific colony-stimulating factor (CSF-1) was isolated. When introduced into mammalian cells, this cDNA directs the expression of CSF-1 that is structurally and functionally indistinguishable from the natural human urinary CSF-1. Direct structural analysis of both the recombinant CSF-1 and the purified human urinary protein revealed that these species contain a sequence of at least 40 amino acids at their carboxyl termini which are not found in the coding region of a 1.6-kilobase CSF-1 cDNA that was previously described. These results demonstrate that the human CSF-1 gene can be expressed to yield at least two different messenger RNA species that encode distinct but related forms of CSF-1.


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Decreased Interleukin-15 From Activated Cord Versus Adult Peripheral Blood Mononuclear Cells and the Effect of Interleukin-15 in Upregulating Antitumor Immune Activity and Cytokine Production in Cord Blood.
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Macrophage Colony-stimulating Factor, CSF-1, and Its Proto-oncogene-encoded Receptor.
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The human hematopoietic colony-stimulating factors.
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