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Science 20 March 1987:
Vol. 235. no. 4795, pp. 1495 - 1498
DOI: 10.1126/science.3029870
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Articles

Science, Vol 235, Issue 4795, 1495-1498
Copyright © 1987 by American Association for the Advancement of Science

articles

Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription

MJ Birnbaum, HC Haspel, and OM Rosen

Elevation of glucose transport is an alteration common to most virally induced tumors. Rat fibroblasts transformed with wild-type or a temperature-sensitive Fujinami sarcoma virus (FSV) were studied in order to determine the mechanisms underlying the increased transport. Five- to tenfold increases in total cellular glucose transporter protein in response to transformation were accompanied by similar increases in transporter messenger RNA levels. This, in turn, was preceded by an absolute increase in the rate of glucose transporter gene transcription within 30 minutes after shift of the temperature-sensitive FSV-transformed cells to the permissive temperature. The transporter messenger RNA levels in transformed fibroblasts were higher than those found in proliferating cells maintained at the nonpermissive temperature. The activation of transporter gene transcription by transformation represents one of the earliest known effects of oncogenesis on the expression of a gene encoding a protein of well-defined function.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)