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Science 13 March 1987:
Vol. 235. no. 4794, pp. 1342 - 1347
DOI: 10.1126/science.235.4794.1342
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Articles

Chromatography with Supercritical Fluids

MILTON L. LEE 1 and KARIN E. MARKIDES 1

1 Department of Chemistry, Brigham Young University, Provo, UT 84602.

In supercritical fluid chromatography (SFC) the mobile phase is neither a gas nor a liquid, but is a supercritical fluid. As a result of the unique properties of supercritical fluids, SFC is rapidly becoming a prominent separation technique for the analysis of reactive, thermally labile, and nonvolatile compounds. This article reviews the history, instrumentation, and practice of the technique. Particular emphasis is placed on the different programming methods that allow elution to be selectively controlled in ways that are unique to SFC.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Physicochemical Studies of PMR Resins. I: Reaction Mechanism and Kinetics at Room Temperature.
M.-F. Grenier-Loustalot and P. Grenier (1991)
High Performance Polymers 3, 113-136
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