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Science 27 February 1987:
Vol. 235. no. 4792, pp. 1053 - 1056
DOI: 10.1126/science.3493528
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Articles

Science, Vol 235, Issue 4792, 1053-1056
Copyright © 1987 by American Association for the Advancement of Science

articles

Isolation of an olfactory cDNA: similarity to retinol-binding protein suggests a role in olfaction

KH Lee, RG Wells, and RR Reed

Molecular cloning techniques were used to isolate and characterize a protein possibly involved in the signal transducing system in olfactory tissue of the frog Rana pipiens. A complementary DNA library was constructed with messenger RNA obtained from frog olfactory neuroepithelium. A 700-base pair complementary DNA clone encoding a protein with a molecular weight of 20,300 was identified by differential hybridization analysis with polyadenylated RNA from olfactory epithelium and nonsensory respiratory epithelium. The messenger RNA corresponding to this clone was abundant in the cells of Bowman's glands in olfactory tissue but not in respiratory epithelium nor in several other tissues. The predicted sequence of this protein is homologous to members of a family of proteins that bind and transport small molecules in serum, suggesting that this protein may also bind and transport odorants in the mucus secreted by Bowman's glands.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A comparative study of odorant binding protein genes: differential expression of the PBP1-GOBP2 gene cluster in Manduca sexta (Lepidoptera) and the organization of OBP genes in Drosophila melanogaster (Diptera).
R. G. Vogt, M. E. Rogers, M.-d. Franco, and M. Sun (2002)
J. Exp. Biol. 205, 719-744
   Abstract »    Full Text »    PDF »
Molecular cloning of odorant-binding protein: member of a ligand carrier family.
J Pevsner, R. Reed, P. Feinstein, and S. Snyder (1988)
Science 241, 336-339
   Abstract »    PDF »
Molecular Transduction in Smell and Taste.
D. Lancet, D. Lazard, J. Heldman, M. Khen, and P. Nef (1988)
Cold Spring Harb Symp Quant Biol 53, 343-348
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)