Science 27 February 1987: Vol. 235. no. 4792, pp. 1043 - 1046 DOI: 10.1126/science.3029864

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Articles

Reply to Sedlak and Snyder: The Little Bighorn of the Biliverdin Reductase Amplification Cycle.

R. Stocker and G. Maghzal (2009)
J. Biol. Chem. 284, le12
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Inhibition of biliverdin reductase increases ANG II-dependent superoxide levels in cultured renal tubular epithelial cells.

S. C. Young, M. V. Storm, J. S. Speed, S. Kelsen, C. V. Tiller, T. Vera, H. A. Drummond, and D. E. Stec (2009)
Am J Physiol Regulatory Integrative Comp Physiol 297, R1546-R1553
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Heme oxygenase: the key to renal function regulation.

N. G. Abraham, J. Cao, D. Sacerdoti, X. Li, and G. Drummond (2009)
Am J Physiol Renal Physiol 297, F1137-F1152
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Low Serum Bilirubin Level as an Independent Predictor of Stroke Incidence: A Prospective Study in Korean Men and Women.

H. Kimm, J. E. Yun, J. Jo, and S. H. Jee (2009)
Stroke 40, 3422-3427
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Limited Role for the Bilirubin-Biliverdin Redox Amplification Cycle in the Cellular Antioxidant Protection by Biliverdin Reductase.

G. J. Maghzal, M.-C. Leck, E. Collinson, C. Li, and R. Stocker (2009)
J. Biol. Chem. 284, 29251-29259
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Oxidized Hemoglobin Is an Endogenous Proinflammatory Agonist That Targets Vascular Endothelial Cells.

G. Silva, V. Jeney, A. Chora, R. Larsen, J. Balla, and M. P. Soares (2009)
J. Biol. Chem. 284, 29582-29595
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Dual Pathways of Carbon Monoxide-Mediated Vasoregulation: Modulation by Redox Mechanisms.

B. D. Lamon, F. F. Zhang, N. Puri, S. V. Brodsky, M. S. Goligorsky, and A. Nasjletti (2009)
Circ. Res. 105, 775-783
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Expression of bilitranslocase in the vascular endothelium and its function as a flavonoid transporter.

A. Maestro, M. Terdoslavich, A. Vanzo, A. Kuku, F. Tramer, V. Nicolin, F. Micali, G. Decorti, and S. Passamonti (2009)
Cardiovasc Res
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Heme Oxygenase-1/Carbon Monoxide: From Metabolism to Molecular Therapy.

S. W. Ryter and A. M. K. Choi (2009)
Am. J. Respir. Cell Mol. Biol. 41, 251-260
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High-Mobility Group Box 1 Contributes to Lethality of Endotoxemia in Heme Oxygenase-1-Deficient Mice.

R. Takamiya, C.-C. Hung, S. R. Hall, K. Fukunaga, T. Nagaishi, T. Maeno, C. Owen, A. A. Macias, L. E. Fredenburgh, A. Ishizaka, et al. (2009)
Am. J. Respir. Cell Mol. Biol. 41, 129-135
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Genome-wide association meta-analysis for total serum bilirubin levels.

A. D. Johnson, M. Kavousi, A. V. Smith, M.-H. Chen, A. Dehghan, T. Aspelund, J.-P. Lin, C. M. van Duijn, T. B. Harris, L. A. Cupples, et al. (2009)
Hum. Mol. Genet. 18, 2700-2710
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Heme Arginate Suppresses Cardiac Lesions and Hypertrophy in Deoxycorticosterone Acetate-Salt Hypertension.

A. Jadhav and J. F. Ndisang (2009)
Experimental Biology and Medicine 234, 764-778
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Up-Regulating the Hemeoxygenase System Enhances Insulin Sensitivity and Improves Glucose Metabolism in Insulin-Resistant Diabetes in Goto-Kakizaki Rats.

J. F. Ndisang and A. Jadhav (2009)
Endocrinology 150, 2627-2636
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Ketamine-induced hepatoprotection: the role of heme oxygenase-1.

J. W. Suliburk, J. L. Ward, K. S. Helmer, S. D. Adams, B. S. Zuckerbraun, and D. W. Mercer (2009)
Am J Physiol Gastrointest Liver Physiol 296, G1360-G1369
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Reactive Oxygen Species Are Not Required for an Arsenic Trioxide-induced Antioxidant Response or Apoptosis.

A. A. Morales, D. Gutman, P. J. Cejas, K. P. Lee, and L. H. Boise (2009)
J. Biol. Chem. 284, 12886-12895
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Total serum bilirubin does not affect vascular reactivity in patients with diabetes.

S. Y. Yeh, J. Doupis, S. Rahangdale, S. Horr, A. Malhotra, and A. Veves (2009)
Vascular Medicine 14, 129-136
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The Heme Oxygenase System Abates Hyperglycemia in Zucker Diabetic Fatty Rats by Potentiating Insulin-Sensitizing Pathways.

J. F. Ndisang, N. lane, and A. Jadhav (2009)
Endocrinology 150, 2098-2108
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Heme Oxygenase-1 Inhibits Pro-Oxidant Induced Hypertrophy in HL-1 Cardiomyocytes.

K. R. Brunt, M. R. Tsuji, J. H. Lai, R. T. Kinobe, W. Durante, W. C. Claycomb, C. A. Ward, and L. G. Melo (2009)
Experimental Biology and Medicine 234, 582-594
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Upregulation of the heme oxygenase system ameliorates postprandial and fasting hyperglycemia in type 2 diabetes.

J. F. Ndisang, N. Lane, and A. Jadhav (2009)
Am J Physiol Endocrinol Metab 296, E1029-E1041
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Measurement of Membrane-Bound Human Heme Oxygenase-1 Activity Using a Chemically Defined Assay System.

W. J. Huber III, C. C. Marohnic, M. Peters, J. Alam, J. R. Reed, B. S. S. Masters, and W. L. Backes (2009)
Drug Metab. Dispos. 37, 857-864
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Differential Regulation of Hepatic Heme Oxygenase-1 Protein With Aging and Heat Stress.

S. A. Bloomer, H. J. Zhang, K. E. Brown, and K. C. Kregel (2009)
J Gerontol A Biol Sci Med Sci 64A, 419-425
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Heme oxygenase system enhances insulin sensitivity and glucose metabolism in streptozotocin-induced diabetes.

J. F. Ndisang and A. Jadhav (2009)
Am J Physiol Endocrinol Metab 296, E829-E841
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Cytoprotective Function of Heme Oxygenase 1 Induced by a Nitrated Cyclic Nucleotide Formed during Murine Salmonellosis.

M. H. Zaki, S. Fujii, T. Okamoto, S. Islam, S. Khan, K. A. Ahmed, T. Sawa, and T. Akaike (2009)
J. Immunol. 182, 3746-3756
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The Right Ventricle Under Pressure: Cellular and Molecular Mechanisms of Right-Heart Failure in Pulmonary Hypertension.

H. J. Bogaard, K. Abe, A. Vonk Noordegraaf, and N. F. Voelkel (2009)
Chest 135, 794-804
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Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethylpyrazine against gentamicin-induced apoptosis in murine renal tubular cells.

Y.-M. Sue, C.-F. Cheng, C.-C. Chang, Y. Chou, C.-H. Chen, and S.-H. Juan (2009)
Nephrol. Dial. Transplant. 24, 769-777
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Water-soluble CO-releasing molecules reduce the development of postoperative ileus via modulation of MAPK/HO-1 signalling and reduction of oxidative stress.

O De Backer, E Elinck, B Blanckaert, L Leybaert, R Motterlini, and R A Lefebvre (2009)
Gut 58, 347-356
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Hemin therapy attenuates kidney injury in deoxycorticosterone acetate-salt hypertensive rats.

A. Jadhav, E. Torlakovic, and J. F. Ndisang (2009)
Am J Physiol Renal Physiol 296, F521-F534
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Carbon Monoxide Inhibits TLR-Induced Dendritic Cell Immunogenicity.

S. Remy, P. Blancou, L. Tesson, V. Tardif, R. Brion, P. J. Royer, R. Motterlini, R. Foresti, M. Painchaut, S. Pogu, et al. (2009)
J. Immunol. 182, 1877-1884
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Interaction Among Heme Oxygenase, Nuclear Factor-{kappa}B, and Transcription Activating Factors in Cardiac Hypertrophy in Hypertension.

A. Jadhav, E. Torlakovic, and J. F. Ndisang (2008)
Hypertension 52, 910-917
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Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production.

S. K. Powers and M. J. Jackson (2008)
Physiol Rev 88, 1243-1276
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Heme oxygenase induction attenuates afferent arteriolar autoregulatory responses.

F. T. Botros, M. C. Prieto-Carrasquero, V. L. Martin, and L. G. Navar (2008)
Am J Physiol Renal Physiol 295, F904-F911
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Heme Oxygenase-1 Prevents Airway Mucus Hypersecretion Induced by Cigarette Smoke in Rodents and Humans.

A. Almolki, A. Guenegou, S. Golda, L. Boyer, M. Benallaoua, N. Amara, R. Bachoual, C. Martin, F. Rannou, S. Lanone, et al. (2008)
Am. J. Pathol. 173, 981-992
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Heme oxygenase attenuates angiotensin II-mediated superoxide production in cultured mouse thick ascending loop of Henle cells.

S. Kelsen, B. J. Patel, L. B. Parker, T. Vera, J. M. Rimoldi, R. S. V. Gadepalli, H. A. Drummond, and D. E. Stec (2008)
Am J Physiol Renal Physiol 295, F1158-F1165
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Heme oxygenase metabolites inhibit tubuloglomerular feedback (TGF).

Y. Ren, M. A. D'Ambrosio, H. Wang, R. Liu, J. L. Garvin, and O. A. Carretero (2008)
Am J Physiol Renal Physiol 295, F1207-F1212
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Hemoxygenase-1 in Cardiovascular Disease.

N. K. Idriss, A. D. Blann, and G. Y.H. Lip (2008)
J. Am. Coll. Cardiol. 52, 971-978
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An Atypical NF-{kappa}B-Regulated Pathway Mediates Phorbol Ester-Dependent Heme Oxygenase-1 Gene Activation in Monocytes.

S. Naidu, N. Wijayanti, S. Santoso, T. Kietzmann, and S. Immenschuh (2008)
J. Immunol. 181, 4113-4123
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BACH1 Is a Specific Repressor of HMOX1 That Is Inactivated by Arsenite.

J. F. Reichard, M. A. Sartor, and A. Puga (2008)
J. Biol. Chem. 283, 22363-22370
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Heme Oxygenase-1 Induction Attenuates Corneal Inflammation and Accelerates Wound Healing after Epithelial Injury.

K. Patil, L. Bellner, G. Cullaro, K. H. Gotlinger, M. W. Dunn, and M. L. Schwartzman (2008)
Invest. Ophthalmol. Vis. Sci. 49, 3379-3386
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Bilirubin Possesses Powerful Immunomodulatory Activity and Suppresses Experimental Autoimmune Encephalomyelitis.

Y. Liu, P. Li, J. Lu, W. Xiong, J. Oger, W. Tetzlaff, and M. Cynader (2008)
J. Immunol. 181, 1887-1897
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Serum Bilirubin and Ferritin Levels Link Heme Oxygenase-1 Gene Promoter Polymorphism and Susceptibility to Coronary Artery Disease in Diabetic Patients.

Y.-H. Chen, L.-Y. Chau, J.-W. Chen, and S.-J. Lin (2008)
Diabetes Care 31, 1615-1620
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Isoporphyrin Intermediate in Heme Oxygenase Catalysis: OXIDATION OF {alpha}-MESO-PHENYLHEME.

J. P. Evans, F. Niemevz, G. Buldain, and P. O. de Montellano (2008)
J. Biol. Chem. 283, 19530-19539
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Heme-oxygenase 1 Gene Expression is a Marker for Hexavalent Chromium-Induced Stress and Toxicity in Human Dermal Fibroblasts.

P. Joseph, Q. He, and C. Umbright (2008)
Toxicol. Sci. 103, 325-334
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Myocardial Protection Against Pressure Overload in Mice Lacking Bach1, a Transcriptional Repressor of Heme Oxygenase-1.

S. Mito, R. Ozono, T. Oshima, Y. Yano, Y. Watari, Y. Yamamoto, A. Brydun, K. Igarashi, and M. Yoshizumi (2008)
Hypertension 51, 1570-1577
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Heme Oxygenase-1 Protects against Neutrophil-Mediated Intestinal Damage by Down-Regulation of Neutrophil p47phox and p67phox Activity and O2- Production in a Two-Hit Model of Alcohol Intoxication and Burn Injury.

X. Li, M. G. Schwacha, I. H. Chaudry, and M. A. Choudhry (2008)
J. Immunol. 180, 6933-6940
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Slipping Past UGT1A1 and Multidrug Resistance-Associated Protein 2 in the Liver: Effects of Steric Compression and Hydrogen Bonding on the Hepatobiliary Elimination of Synthetic Bilirubins.

A. F. McDonagh, S. E. Boiadjiev, and D. A. Lightner (2008)
Drug Metab. Dispos. 36, 930-936
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Decreased expression of haem oxygenase-1 by alveolar macrophages in idiopathic pulmonary fibrosis.

Q. Ye, Y. Dalavanga, N. Poulakis, S. U. Sixt, J. Guzman, and U. Costabel (2008)
Eur. Respir. J. 31, 1030-1036
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Erythroid Apoptosis in Idiopathic Neonatal Jaundice.

H. Ozkan, H. Oren, M. Tatli, H. Ates, A. Kumral, and N. Duman (2008)
Pediatrics 121, e1348-e1351
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Maternal and Fetal Hemodynamics by Heme Oxygenase in Mice.

H. Zhao, R. J. Wong, T. C. Doyle, N. Nayak, H. J. Vreman, C. H. Contag, and D. K. Stevenson (2008)
Biol Reprod 78, 744-751
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Pharmacological and Clinical Aspects of Heme Oxygenase.

N. G. Abraham and A. Kappas (2008)
Pharmacol. Rev. 60, 79-127
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Ozone, Oxidant Defense Genes, and Risk of Asthma during Adolescence.

T. Islam, R. McConnell, W. J. Gauderman, E. Avol, J. M. Peters, and F. D. Gilliland (2008)
Am. J. Respir. Crit. Care Med. 177, 388-395
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Review: Oxidative stress and excitotoxicity: a therapeutic issue in multiple sclerosis?.

R.E. Gonsette (2008)
Multiple Sclerosis 14, 22-34
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Serum Total Bilirubin Level and Prevalent Lower-Extremity Peripheral Arterial Disease: National Health and Nutrition Examination Survey (NHANES) 1999 to 2004.

T. S. Perlstein, R. L. Pande, J. A. Beckman, and M. A. Creager (2008)
Arterioscler Thromb Vasc Biol 28, 166-172
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Photoreceptor Protection against Light Damage by AAV-Mediated Overexpression of Heme Oxygenase-1.

M.-H. Sun, J.-H. S. Pang, S.-L. Chen, P.-C. Kuo, K.-J. Chen, L.-Y. Kao, J.-Y. Wu, K.-K. Lin, and Y.-P. Tsao (2007)
Invest. Ophthalmol. Vis. Sci. 48, 5699-5707
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Heme Oxygenase-1 Inhibits the Expression of Adhesion Molecules Associated with Endothelial Cell Activation via Inhibition of NF-{kappa}B RelA Phosphorylation at Serine 276.

M. P. Seldon, G. Silva, N. Pejanovic, R. Larsen, I. P. Gregoire, J. Filipe, J. Anrather, and M. P. Soares (2007)
J. Immunol. 179, 7840-7851
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Regulation of TNF-{alpha}-activated PKC-{zeta} signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase.

N. Lerner-Marmarosh, T. Miralem, P. E. M. Gibbs, and M. D. Maines (2007)
FASEB J 21, 3949-3962
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Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats.

A. L'Abbate, D. Neglia, C. Vecoli, M. Novelli, V. Ottaviano, S. Baldi, R. Barsacchi, A. Paolicchi, P. Masiello, G. S. Drummond, et al. (2007)
Am J Physiol Heart Circ Physiol 293, H3532-H3541
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Relationship Between Gilbert Syndrome and Prevalence of Vascular Complications in Patients With Diabetes.

T. Inoguchi, S. Sasaki, K. Kobayashi, R. Takayanagi, and T. Yamada (2007)
JAMA 298, 1398-1400
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Specificity protein 1 and Smad-dependent regulation of human heme oxygenase-1 gene by transforming growth factor-beta1 in renal epithelial cells.

A. Traylor, T. Hock, and N. Hill-Kapturczak (2007)
Am J Physiol Renal Physiol 293, F885-F894
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Heme Oxygenase-1: A Novel Key Player in the Development of Tolerance in Response to Organic Nitrates.

P. Wenzel, M. Oelze, M. Coldewey, M. Hortmann, A. Seeling, U. Hink, H. Mollnau, D. Stalleicken, H. Weiner, J. Lehmann, et al. (2007)
Arterioscler Thromb Vasc Biol 27, 1729-1735
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Effect of cigarette smoke on placental antioxidant enzyme expression.

E. H. Sidle, R. Casselman, and G. N. Smith (2007)
Am J Physiol Regulatory Integrative Comp Physiol 293, R754-R758
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Heme Oxygenase-1 Protein Localizes to the Nucleus and Activates Transcription Factors Important in Oxidative Stress.

Q. Lin, S. Weis, G. Yang, Y.-H. Weng, R. Helston, K. Rish, A. Smith, J. Bordner, T. Polte, F. Gaunitz, et al. (2007)
J. Biol. Chem. 282, 20621-20633
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Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction.

X. Liu, J. A. Simpson, K. R. Brunt, C. A. Ward, S. R. R. Hall, R. T. Kinobe, V. Barrette, M. Y. Tse, S. C. Pang, A. S. Pachori, et al. (2007)
Am J Physiol Heart Circ Physiol 293, H48-H59
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An analysis of the DOCA-salt model of hypertension in HO-1-/- mice and the Gunn rat.

K. A. Nath, L. V. d'Uscio, J. P. Juncos, A. J. Croatt, M. C. Manriquez, S. T. Pittock, and Z. S. Katusic (2007)
Am J Physiol Heart Circ Physiol 293, H333-H342
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Bilberry (Vaccinium myrtillus) Anthocyanins Modulate Heme Oxygenase-1 and Glutathione S-Transferase-pi Expression in ARPE-19 Cells.

P. E. Milbury, B. Graf, J. M. Curran-Celentano, and J. B. Blumberg (2007)
Invest. Ophthalmol. Vis. Sci. 48, 2343-2349
 |  Abstract »  |  Full Text »  |  PDF »

Effect of haemodiafiltration with online regeneration of ultrafiltrate on oxidative stress in dialysis patients.

L. A Calo, A. Naso, G. Carraro, M. L. Wratten, E. Pagnin, L. Bertipaglia, M. Rebeschini, P. A Davis, A. Piccoli, and C. Cascone (2007)
Nephrol. Dial. Transplant. 22, 1413-1419
 |  Abstract »  |  Full Text »  |  PDF »

Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers.

K. Okada, J. Shoda, M. Kano, S. Suzuki, N. Ohtake, M. Yamamoto, H. Takahashi, H. Utsunomiya, K. Oda, K. Sato, et al. (2007)
Am J Physiol Gastrointest Liver Physiol 292, G1450-G1463
 |  Abstract »  |  Full Text »  |  PDF »

Tin protoporphyrin induces intestinal chloride secretion by inducing light oxidation processes.

A. Uc, K. J. Reszka, G. R. Buettner, and J. B. Stokes (2007)
Am J Physiol Cell Physiol 292, C1906-C1914
 |  Abstract »  |  Full Text »  |  PDF »

Non-heme Induction of Heme Oxygenase-1 Does Not Alter Cellular Iron Metabolism.

A. D. Sheftel, S. F. Kim, and P. Ponka (2007)
J. Biol. Chem. 282, 10480-10486
 |  Abstract »  |  Full Text »  |  PDF »

HO-1 induction lowers blood pressure and superoxide production in the renal medulla of angiotensin II hypertensive mice.

T. Vera, S. Kelsen, L. L. Yanes, J. F. Reckelhoff, and D. E. Stec (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R1472-R1478
 |  Abstract »  |  Full Text »  |  PDF »

Genetic deletion of p66Shc adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.

G. G. Camici, M. Schiavoni, P. Francia, M. Bachschmid, I. Martin-Padura, M. Hersberger, F. C. Tanner, P. Pelicci, M. Volpe, P. Anversa, et al. (2007)
PNAS 104, 5217-5222
 |  Abstract »  |  Full Text »  |  PDF »

Human Biliverdin Reductase, a Previously Unknown Activator of Protein Kinase C betaII.

M. D. Maines, T. Miralem, N. Lerner-Marmarosh, J. Shen, and P. E. M. Gibbs (2007)
J. Biol. Chem. 282, 8110-8122
 |  Abstract »  |  Full Text »  |  PDF »

Marked Hyperbilirubinemia Associated With the Heme Oxygenase-1 Gene Promoter Microsatellite Polymorphism in a Boy With Autoimmune Hemolytic Anemia.

S. Immenschuh, Y. Shan, H. Kroll, S. Santoso, W. Wossmann, G. Bein, and H. L. Bonkovsky (2007)
Pediatrics 119, e764-e767
 |  Abstract »  |  Full Text »  |  PDF »

Neonatal Jaundice: Bilirubin Physiology and Clinical Chemistry.

R. J. Wong, D. K. Stevenson, C. E. Ahlfors, and H. J. Vreman (2007)
NeoReviews 8, e58-e67
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacology Review: Tin Mesoporphyrin for the Prevention of Severe Neonatal Hyperbilirubinemia.

R. J. Wong, V. K. Bhutani, H. J. Vreman, and D. K. Stevenson (2007)
NeoReviews 8, e77-e84
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Heme Oxygenase-1 in Pulmonary Disease.

L. E. Fredenburgh, M. A. Perrella, and S. A. Mitsialis (2007)
Am. J. Respir. Cell Mol. Biol. 36, 158-165
 |  Abstract »  |  Full Text »  |  PDF »

Carbon Monoxide and Bilirubin: Potential Therapies for Pulmonary/Vascular Injury and Disease.

S. W. Ryter, D. Morse, and A. M. K. Choi (2007)
Am. J. Respir. Cell Mol. Biol. 36, 175-182
 |  Abstract »  |  Full Text »  |  PDF »

Physiology and Pathophysiology of Heme: Implications for Kidney Disease.

M. J. Tracz, J. Alam, and K. A. Nath (2007)
J. Am. Soc. Nephrol. 18, 414-420
 |  Abstract »  |  Full Text »  |  PDF »

Intravenous bilirubin provides incomplete protection against renal ischemia-reperfusion injury in vivo.

K. Kirkby, C. Baylis, A. Agarwal, B. Croker, L. Archer, and C. Adin (2007)
Am J Physiol Renal Physiol 292, F888-F894
 |  Abstract »  |  Full Text »  |  PDF »

Motexafin Gadolinium-Induced Cell Death Correlates with Heme oxygenase-1 Expression and Inhibition of P450 Reductase-Dependent Activities.

J. P. Evans, F. Xu, M. Sirisawad, R. Miller, L. Naumovski, and P. R. O. de Montellano (2007)
Mol. Pharmacol. 71, 193-200
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Heme Oxygenase-1: A Novel Drug Target for Atherosclerotic Diseases?.

R. Stocker and M. A. Perrella (2006)
Circulation 114, 2178-2189
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Heme Oxygenase-2 Is a Critical Determinant for Execution of an Acute Inflammatory and Reparative Response.

F. Seta, L. Bellner, R. Rezzani, R. F. Regan, M. W. Dunn, N. G. Abraham, K. Gronert, and M. Laniado-Schwartzman (2006)
Am. J. Pathol. 169, 1612-1623
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NO Modulates NADPH Oxidase Function Via Heme Oxygenase-1 in Human Endothelial Cells.

F. Jiang, S. J. Roberts, S. r. Datla, and G. J. Dusting (2006)
Hypertension 48, 950-957
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CD163-Mediated Hemoglobin-Heme Uptake Activates Macrophage HO-1, Providing an Antiinflammatory Function.

N. G. Abraham and G. Drummond (2006)
Circ. Res. 99, 911-914
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Mechanical ventilation promotes redox status alterations in the diaphragm.

D. J. Falk, K. C. DeRuisseau, D. L. Van Gammeren, M. A. Deering, A. N. Kavazis, and S. K. Powers (2006)
J Appl Physiol 101, 1017-1024
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Endothelial STAT3 is essential for the protective effects of HO-1 in oxidant-induced lung injury.

X. Zhang, P. Shan, G. Jiang, S. S-M. Zhang, L. E. Otterbein, X.-Y. Fu, and P. J. Lee (2006)
FASEB J 20, 2156-2158
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Repair of DNA Damage Induced by Bile Salts in Salmonella enterica.

A. I. Prieto, F. Ramos-Morales, and J. Casadesus (2006)
Genetics 174, 575-584
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Protection of Human Vascular Smooth Muscle Cells From H2O2-Induced Apoptosis Through Functional Codependence Between HO-1 and AKT.

K. R. Brunt, K. K. Fenrich, G. Kiani, M. Yat Tse, S. C. Pang, C. A. Ward, and L. G. Melo (2006)
Arterioscler Thromb Vasc Biol 26, 2027-2034
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Anomalous Renal Effects of Tin Protoporphyrin in a Murine Model of Sickle Cell Disease.

J. P. Juncos, J. P. Grande, N. Murali, A. J. Croatt, L. A. Juncos, R. P. Hebbel, Z. S. Katusic, and K. A. Nath (2006)
Am. J. Pathol. 169, 21-31
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Experimental evidence that egg color indicates female condition at laying in a songbird.

J. Moreno, E. Lobato, J. Morales, S. Merino, G. Tomas, J. Martinez-de la Puente, J. J. Sanz, R. Mateo, and J. J. Soler (2006)
Behav. Ecol. 17, 651-655
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Genetic ablation of the transcription repressor Bach1 leads to myocardial protection against ischemia/reperfusion in mice..

Y. Yano, R. Ozono, Y. Oishi, M. Kambe, M. Yoshizumi, T. Ishida, S. Omura, T. Oshima, and K. Igarashi (2006)
Genes Cells 11, 791-803
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HO-1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism.

D. P. Converso, C. Taille, M. C. Carreras, A. Jaitovich, J. J. Poderoso, and J. Boczkowski (2006)
FASEB J 20, 1236-1238
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A heme-degradation pathway in a blood-sucking insect.

G. O. Paiva-Silva, C. Cruz-Oliveira, E. S. Nakayasu, C. M. Maya-Monteiro, B. C. Dunkov, H. Masuda, I. C. Almeida, and P. L. Oliveira (2006)
PNAS 103, 8030-8035
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Iron Released by Sodium Nitroprusside Contributes to Heme Oxygenase-1 Induction via the cAMP-Protein Kinase A-Mitogen-Activated Protein Kinase Pathway in RAW 264.7 Cells.

H. J. Kim, I. Tsoy, M. K. Park, Y. S. Lee, J. H. Lee, H. G. Seo, and K. C. Chang (2006)
Mol. Pharmacol. 69, 1633-1640
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Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging.

B. J. Wu, K. Kathir, P. K. Witting, K. Beck, K. Choy, C. Li, K. D. Croft, T. A. Mori, D. Tanous, M. R. Adams, et al. (2006)
J. Exp. Med. 203, 1117-1127
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