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Science 20 February 1987:
Vol. 235. no. 4791, pp. 885 - 890
DOI: 10.1126/science.2880399
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Articles

Science, Vol 235, Issue 4791, 885-890
Copyright © 1987 by American Association for the Advancement of Science

articles

The genetic defect causing familial Alzheimer's disease maps on chromosome 21

PH St George-Hyslop, RE Tanzi, RJ Polinsky, JL Haines, L Nee, PC Watkins, RH Myers, RG Feldman, D Pollen, D Drachman, and al. et

Alzheimer's disease is a leading cause of morbidity and mortality among the elderly. Several families have been described in which Alzheimer's disease is caused by an autosomal dominant gene defect. The chromosomal location of this defective gene has been discovered by using genetic linkage to DNA markers on chromosome 21. The localization on chromosome 21 provides an explanation for the occurrence of Alzheimer's disease-like pathology in Down syndrome. Isolation and characterization of the gene at this locus may yield new insights into the nature of the defect causing familial Alzheimer's disease and possibly, into the etiology of all forms of Alzheimer's disease.


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