Science 20 February 1987: Vol. 235. no. 4791, pp. 880 - 884 DOI: 10.1126/science.2949367

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Articles

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies.

A. P. Lillis, L. B. Van Duyn, J. E. Murphy-Ullrich, and D. K. Strickland (2008)
Physiol Rev 88, 887-918
 |  Abstract »  |  Full Text »  |  PDF »

Retromer Sorting: A Pathogenic Pathway in Late-Onset Alzheimer Disease.

S. A. Small (2008)
Arch Neurol 65, 323-328
 |  Abstract »  |  Full Text »  |  PDF »

Translation of Genetic Discoveries into Clinical Therapies.

D. G. Hackam and A. S. Hackam (2008)
Ann Intern Med 148, 246-247
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{beta}-Amyloid Modulation of Synaptic Transmission and Plasticity.

D. V. Venkitaramani, J. Chin, W. J. Netzer, G. K. Gouras, S. Lesne, R. Malinow, and P. J. Lombroso (2007)
J. Neurosci. 27, 11832-11837
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Selective vulnerability of different types of commissural neurons for amyloid {beta}-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology.

E. Capetillo-Zarate, M. Staufenbiel, D. Abramowski, C. Haass, A. Escher, C. Stadelmann, H. Yamaguchi, O. D. Wiestler, and D. R. Thal (2006)
Brain 129, 2992-3005
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's Disease and the Aging Brain.

R. D. Terry (2006)
J Geriatr Psychiatry Neurol 19, 125-128
 |  Abstract »  |  PDF »

Genetics and Dementia Nosology.

D. Blacker and S. Lovestone (2006)
J Geriatr Psychiatry Neurol 19, 186-191
 |  Abstract »  |  PDF »

An early specific cell-cell interaction occurs in the production of beta-amyloid in cell cultures.

N. N. Dewji, D. Mukhopadhyay, and S. J. Singer (2006)
PNAS 103, 1540-1545
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein (apo) E4 enhances amyloid {beta} peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target.

S. Ye, Y. Huang, K. Mullendorff, L. Dong, G. Giedt, E. C. Meng, F. E. Cohen, I. D. Kuntz, K. H. Weisgraber, and R. W. Mahley (2005)
PNAS 102, 18700-18705
 |  Abstract »  |  Full Text »  |  PDF »

Agrin binds {alpha}-synuclein and modulates {alpha}-synuclein fibrillation.

I-H. Liu, V. N. Uversky, L. A. Munishkina, A. L. Fink, W. Halfter, and G. J. Cole (2005)
Glycobiology 15, 1320-1331
 |  Abstract »  |  Full Text »  |  PDF »

Translational Research on the Way to Effective Therapy for Alzheimer Disease.

R. N. Rosenberg (2005)
Arch Gen Psychiatry 62, 1186-1192
 |  Abstract »  |  Full Text »  |  PDF »

BRI2 Interacts with Amyloid Precursor Protein (APP) and Regulates Amyloid {beta} (A{beta}) Production.

A. Fotinopoulou, M. Tsachaki, M. Vlavaki, A. Poulopoulos, A. Rostagno, B. Frangione, J. Ghiso, and S. Efthimiopoulos (2005)
J. Biol. Chem. 280, 30768-30772
 |  Abstract »  |  Full Text »  |  PDF »

The Familial Dementia BRI2 Gene Binds the Alzheimer Gene Amyloid-{beta} Precursor Protein and Inhibits Amyloid-{beta} Production.

S. Matsuda, L. Giliberto, Y. Matsuda, P. Davies, E. McGowan, F. Pickford, J. Ghiso, B. Frangione, and L. D'Adamio (2005)
J. Biol. Chem. 280, 28912-28916
 |  Abstract »  |  Full Text »  |  PDF »

Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers.

A. Demuro, E. Mina, R. Kayed, S. C. Milton, I. Parker, and C. G. Glabe (2005)
J. Biol. Chem. 280, 17294-17300
 |  Abstract »  |  Full Text »  |  PDF »

Autoantibodies to Redox-modified Oligomeric A{beta} Are Attenuated in the Plasma of Alzheimer's Disease Patients.

R. D. Moir, K. A. Tseitlin, S. Soscia, B. T. Hyman, M. C. Irizarry, and R. E Tanzi (2005)
J. Biol. Chem. 280, 17458-17463
 |  Abstract »  |  Full Text »  |  PDF »

The Amyloid Precursor Protein (APP) of Alzheimer Disease and Its Paralog, APLP2, Modulate the Cu/Zn-Nitric Oxide-catalyzed Degradation of Glypican-1 Heparan Sulfate in Vivo.

R. Cappai, F. Cheng, G. D. Ciccotosto, B. E. Needham, C. L. Masters, G. Multhaup, L.-A. Fransson, and K. Mani (2005)
J. Biol. Chem. 280, 13913-13920
 |  Abstract »  |  Full Text »  |  PDF »

Defective Neuromuscular Synapses in Mice Lacking Amyloid Precursor Protein (APP) and APP-Like Protein 2.

P. Wang, G. Yang, D. R. Mosier, P. Chang, T. Zaidi, Y.-D. Gong, N.-M. Zhao, B. Dominguez, K.-F. Lee, W.-B. Gan, et al. (2005)
J. Neurosci. 25, 1219-1225
 |  Abstract »  |  Full Text »  |  PDF »

BACE overexpression alters the subcellular processing of APP and inhibits A{beta} deposition in vivo.

E. B. Lee, B. Zhang, K. Liu, E. A. Greenbaum, R. W. Doms, J. Q. Trojanowski, and V. M.-Y. Lee (2005)
J. Cell Biol. 168, 291-302
 |  Abstract »  |  Full Text »  |  PDF »

BACE1 Gene Expression and Protein Degradation.

W. ZHOU, H. QING, Y. TONG, and W. SONG (2004)
Ann. N.Y. Acad. Sci. 1035, 49-67
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Sterols on {beta}-Amyloid Peptide (A{beta}P 1-40) Channel Formation and their Properties in Planar Lipid Membranes.

S. Micelli, D. Meleleo, V. Picciarelli, and E. Gallucci (2004)
Biophys. J. 86, 2231-2237
 |  Abstract »  |  Full Text »  |  PDF »

Redox-Active Metals, Oxidative Stress, and Alzheimer's Disease Pathology.

X. HUANG, R. D. MOIR, R. E. TANZI, A. I. BUSH, and J. T. ROGERS (2004)
Ann. N.Y. Acad. Sci. 1012, 153-163
 |  Abstract »  |  Full Text »  |  PDF »

Fine mapping of the {alpha}-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.

N. Ertekin-Taner, J. Ronald, H. Asahara, L. Younkin, M. Hella, S. Jain, E. Gnida, S. Younkin, D. Fadale, Y. Ohyagi, et al. (2003)
Hum. Mol. Genet. 12, 3133-3143
 |  Abstract »  |  Full Text »  |  PDF »

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid A{beta} production in APP23 transgenic mice.

T. A. Bayer, S. Schafer, A. Simons, A. Kemmling, T. Kamer, R. Tepest, A. Eckert, K. Schussel, O. Eikenberg, C. Sturchler-Pierrat, et al. (2003)
PNAS 100, 14187-14192
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid {beta}-Protein Stimulates the Expression of Urokinase-type Plasminogen Activator (uPA) and Its Receptor (uPAR) in Human Cerebrovascular Smooth Muscle Cells.

J. Davis, M. R. Wagner, W. Zhang, F. Xu, and W. E. Van Nostrand (2003)
J. Biol. Chem. 278, 19054-19061
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An Iron-responsive Element Type II in the 5'-Untranslated Region of the Alzheimer's Amyloid Precursor Protein Transcript.

J. T. Rogers, J. D. Randall, C. M. Cahill, P. S. Eder, X. Huang, H. Gunshin, L. Leiter, J. McPhee, S. S. Sarang, T. Utsuki, et al. (2002)
J. Biol. Chem. 277, 45518-45528
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Localization of a Fibrillar Amyloid beta -Protein Binding Domain on Its Precursor.

W. E. Van Nostrand, J. P. Melchor, D. M. Keane, S. M. Saporito-Irwin, G. Romanov, J. Davis, and F. Xu (2002)
J. Biol. Chem. 277, 36392-36398
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Explaining the Cause of the Amyloid Burden in Alzheimer Disease.

R. N. Rosenberg (2002)
Arch Neurol 59, 1367-1368
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Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain.

D. Lutjohann, A. Brzezinka, E. Barth, D. Abramowski, M. Staufenbiel, K. von Bergmann, K. Beyreuther, G. Multhaup, and T. A. Bayer (2002)
J. Lipid Res. 43, 1078-1085
 |  Abstract »  |  Full Text »  |  PDF »

Novel Real-Time Quantitative PCR Test for Trisomy 21.

B. Zimmermann, W. Holzgreve, F. Wenzel, and S. Hahn (2002)
Clin. Chem. 48, 362-363
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Recognition of alpha 2-Macroglobulin by the Low Density Lipoprotein Receptor-related Protein Requires the Cooperation of Two Ligand Binding Cluster Regions.

I. Mikhailenko, F. D. Battey, M. Migliorini, J. F. Ruiz, K. Argraves, M. Moayeri, and D. K. Strickland (2001)
J. Biol. Chem. 276, 39484-39491
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Reduced levels of amyloid {beta}-peptide antibody in Alzheimer disease.

Y. Du, R. Dodel, H. Hampel, K. Buerger, S. Lin, B. Eastwood, K. Bales, F. Gao, H.-J. Moeller, W. Oertel, et al. (2001)
Neurology 57, 801-805
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DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease.

Y. Yang, D. S. Geldmacher, and K. Herrup (2001)
J. Neurosci. 21, 2661-2668
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid Precursor Protein in Platelets of Patients With Alzheimer Disease: Effect of Acetylcholinesterase Inhibitor Treatment.

B. Borroni, F. Colciaghi, L. Pastorino, C. Pettenati, E. Cottini, L. Rozzini, R. Monastero, G. L. Lenzi, F. Cattabeni, M. Di Luca, et al. (2001)
Arch Neurol 58, 442-446
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Recombinant, Soluble {beta}-Secretase from an Insect Cell Expression System.

W. D. Mallender, D. Yager, L. Onstead, M. R. Nichols, C. Eckman, K. Sambamurti, L. M. Kopcho, J. Marcinkeviciene, R. A. Copeland, and T. L. Rosenberry (2001)
Mol. Pharmacol. 59, 619-626
 |  Abstract »  |  Full Text »

Human bleomycin hydrolase regulates the secretion of amyloid precursor protein.

I. M. LEFTEROV, R. P. KOLDAMOVA, and J. S. LAZO (2000)
FASEB J 14, 1837-1847
 |  Abstract »  |  Full Text »

The molecular and genetic basis of AD: The end of the beginning: The 2000 Wartenberg lecture.

R. N. Rosenberg (2000)
Neurology 54, 2045-2054
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Alzheimer's beta -Amyloid, Human Islet Amylin, and Prion Protein Fragment Evoke Intracellular Free Calcium Elevations by a Common Mechanism in a Hypothalamic GnRH Neuronal Cell Line.

M. Kawahara, Y. Kuroda, N. Arispe, and E. Rojas (2000)
J. Biol. Chem. 275, 14077-14083
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's Disease, {beta}-Amyloid Protein and Zinc.

X. Huang, M. P. Cuajungco, C. S. Atwood, R. D. Moir, R. E. Tanzi, and A. I. Bush (2000)
J. Nutr. 130, 1488S-1492
 |  Abstract »  |  Full Text »

Modulation of beta -Amyloid Precursor Protein Processing by the Low Density Lipoprotein Receptor-related Protein (LRP). EVIDENCE THAT LRP CONTRIBUTES TO THE PATHOGENESIS OF ALZHEIMER'S DISEASE.

P. G. Ulery, J. Beers, I. Mikhailenko, R. E. Tanzi, G. W. Rebeck, B. T. Hyman, and D. K. Strickland (2000)
J. Biol. Chem. 275, 7410-7415
 |  Abstract »  |  Full Text »  |  PDF »

Identification of cis-Elements Regulating Exon 15 Splicing of the Amyloid Precursor Protein Pre-mRNA.

C. Bergsdorf, K. Paliga, S. Kreger, C. L. Masters, and K. Beyreuther (2000)
J. Biol. Chem. 275, 2046-2056
 |  Abstract »  |  Full Text »  |  PDF »

BACE Maps to Chromosome 11 and a BACE Homolog, BACE2, Reside in the Obligate Down Syndrome Region of Chromosome 21 .

A. J. Saunders, T. Kim, R. E. Tanzi;, W. Fan, B. D. Bennett, S. Babu-Kahn, Y. Luo, J. Louis, M. McCaleb, M. Citron, et al. (1999)
Science 286, 1255a-1255
 |  Abstract »  |  Full Text »

Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis.

X. Xu, D. Yang, T. Wyss-Coray, J. Yan, L. Gan, Y. Sun, and L. Mucke (1999)
PNAS 96, 7547-7552
 |  Abstract »  |  Full Text »  |  PDF »

Endogenous Proteins Controlling Amyloid beta -Peptide Polymerization. POSSIBLE IMPLICATIONS FOR beta -AMYLOID FORMATION IN THE CENTRAL NERVOUS SYSTEM AND IN PERIPHERAL TISSUES.

B. Bohrmann, L. Tjernberg, P. Kuner, S. Poli, B. Levet-Trafit, J. Naslund, G. Richards, W. Huber, H. Dobeli, and C. Nordstedt (1999)
J. Biol. Chem. 274, 15990-15995
 |  Abstract »  |  Full Text »  |  PDF »

Role of Phosphorylation of Alzheimer's Amyloid Precursor Protein during Neuronal Differentiation.

K. Ando, M. Oishi, S. Takeda, K.-i. Iijima, T. Isohara, A. C. Nairn, Y. Kirino, P. Greengard, and T. Suzuki (1999)
J. Neurosci. 19, 4421-4427
 |  Abstract »  |  Full Text »  |  PDF »

Translation of the Alzheimer Amyloid Precursor Protein mRNA Is Up-regulated by Interleukin-1 through 5'-Untranslated Region Sequences.

J. T. Rogers, L. M. Leiter, J. McPhee, C. M. Cahill, S.-S. Zhan, H. Potter, and L. N. G. Nilsson (1999)
J. Biol. Chem. 274, 6421-6431
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of a Neuron-specific Protein Containing PDZ Domains with Alzheimer's Amyloid Precursor Protein.

S. Tomita, T. Ozaki, H. Taru, S. Oguchi, S. Takeda, Y. Yagi, S. Sakiyama, Y. Kirino, and T. Suzuki (1999)
J. Biol. Chem. 274, 2243-2254
 |  Abstract »  |  Full Text »  |  PDF »

Using Knockout and Transgenic Mice to Study Neurophysiology and Behavior.

M. R. PICCIOTTO and K. WICKMAN (1998)
Physiol Rev 78, 1131-1163
 |  Abstract »  |  Full Text »  |  PDF »

Differential Level of Platelet Amyloid {beta} Precursor Protein Isoforms: An Early Marker for Alzheimer Disease.

M. Di Luca, L. Pastorino, A. Bianchetti, J. Perez, L. A. Vignolo, G. L. Lenzi, M. Trabucchi, F. Cattabeni, and A. Padovani (1998)
Arch Neurol 55, 1195-1200
 |  Abstract »  |  Full Text »  |  PDF »

A Basic Amino Acid in the Cytoplasmic Domain of Alzheimer's beta -Amyloid Precursor Protein (APP) Is Essential for Cleavage of APP at the alpha -Site.

S. Tomita, Y. Kirino, and T. Suzuki (1998)
J. Biol. Chem. 273, 19304-19310
 |  Abstract »  |  Full Text »  |  PDF »

Dramatic Aggregation of Alzheimer Abeta by Cu(II) Is Induced by Conditions Representing Physiological Acidosis.

C. S. Atwood, R. D. Moir, X. Huang, R. C. Scarpa, N. M. E. Bacarra, D. M. Romano, M. A. Hartshorn, R. E. Tanzi, and A. I. Bush (1998)
J. Biol. Chem. 273, 12817-12826
 |  Abstract »  |  Full Text »  |  PDF »

Fourteen Newly Recognized Proteins at the Human Neuromuscular Junctions-and Their Nonjunctional Accumulation in Inclusion-Body Myositisa.

V. ASKANAS, W. K. ENGEL, and R. B. ALVAREZ (1998)
Ann. N.Y. Acad. Sci. 841, 28-56
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Cleavage of Alzheimer's Amyloid Precursor Protein (APP) by Secretases Occurs after O-Glycosylation of APP in the Protein Secretory Pathway. IDENTIFICATION OF INTRACELLULAR COMPARTMENTS IN WHICH APP CLEAVAGE OCCURS WITHOUT USING TOXIC AGENTS THAT INTERFERE WITH PROTEIN METABOLISM.

S. Tomita, Y. Kirino, and T. Suzuki (1998)
J. Biol. Chem. 273, 6277-6284
 |  Abstract »  |  Full Text »  |  PDF »

The Genetics of Alzheimer Disease: Current Status and Future Prospects.

D. Blacker and R. E. Tanzi (1998)
Arch Neurol 55, 294-296
 |  Abstract »  |  Full Text »  |  PDF »

Relative Increase in Alzheimer's Disease of Soluble Forms of Cerebral Abeta Amyloid Protein Precursor Containing the Kunitz Protease Inhibitory Domain.

R. D. Moir, T. Lynch, A. I. Bush, S. Whyte, A. Henry, S. Portbury, G. Multhaup, D. H. Small, R. E. Tanzi, K. Beyreuther, et al. (1998)
J. Biol. Chem. 273, 5013-5019
 |  Abstract »  |  Full Text »  |  PDF »

Differential Effects of the Swedish Mutant Amyloid Precursor Protein on beta -Amyloid Accumulation and Secretion in Neurons and Nonneuronal Cells.

M. S. Forman, D. G. Cook, S. Leight, R. W. Doms, and V. M.-Y. Lee (1997)
J. Biol. Chem. 272, 32247-32253
 |  Abstract »  |  Full Text »  |  PDF »

Prevention of Amyloid-Like Deposition by a Selective Prolyl Endopeptidase Inhibitor, Y-29794, in Senescence-Accelerated Mouse.

A. Kato, A. Fukunari, Y. Sakai, and T. Nakajima (1997)
J. Pharmacol. Exp. Ther. 283, 328-335
 |  Abstract »  |  Full Text »

The Profile of Soluble Amyloid beta Protein in Cultured Cell Media. DETECTION AND QUANTIFICATION OF AMYLOID beta PROTEIN AND VARIANTS BY IMMUNOPRECIPITATION-MASS SPECTROMETRY.

R. Wang, D. Sweeney, S. E. Gandy, and S. S. Sisodia (1996)
J. Biol. Chem. 271, 31894-31902
 |  Abstract »  |  Full Text »  |  PDF »

beta -Secretase Processing of the beta -Amyloid Precursor Protein in Transgenic Mice Is Efficient in Neurons but Inefficient in Astrocytes.

J. Zhao, L. Paganini, L. Mucke, M. Gordon, L. Refolo, M. Carman, S. Sinha, T. Oltersdorf, I. Lieberburg, and L. McConlogue (1996)
J. Biol. Chem. 271, 31407-31411
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid beta  Peptide of Alzheimer's Disease Downregulates Bcl-2 and Upregulates Bax Expression in Human Neurons.

E. Paradis, H. Douillard, M. Koutroumanis, C. Goodyer, and A. LeBlanc (1996)
J. Neurosci. 16, 7533-7539
 |  Abstract »  |  Full Text »  |  PDF »

The Alternatively Spliced Kunitz Protease Inhibitor Domain Alters Amyloid beta Protein Precursor Processing and Amyloid beta Protein Production in Cultured Cells.

L. Ho, K.-i. Fukuchi, and StevenG. Younkin (1996)
J. Biol. Chem. 271, 30929-30934
 |  Abstract »  |  Full Text »  |  PDF »

The Initiator Element and Proximal Upstream Sequences Affect Transcriptional Activity and Start Site Selection in the Amyloid beta -Protein Precursor Promoter.

W. W. Quitschke, J. P. Matthews, R. J. Kraus, and A. A. Vostrov (1996)
J. Biol. Chem. 271, 22231-22239
 |  Abstract »  |  Full Text »  |  PDF »

beta -Amyloid Peptide Secretion by a Microglial Cell Line Is Induced by beta -Amyloid-(25-35) and Lipopolysaccharide.

L. Bitting, A. Naidu, B. Cordell, and G. M. Murphy Jr. (1996)
J. Biol. Chem. 271, 16084-16089
 |  Abstract »  |  Full Text »  |  PDF »

APP-BP1, a Novel Protein That Binds to the Carboxyl-terminal Region of the Amyloid Precursor Protein.

N. Chow, J. R. Korenberg, X.-N. Chen, and R. L. Neve (1996)
J. Biol. Chem. 271, 11339-11346
 |  Abstract »  |  Full Text »  |  PDF »

Coagulation Factor XIa Cleaves the RHDS Sequence and Abolishes the Cell Adhesive Properties of the Amyloid beta-Protein.

S. M. Saporito-Irwin and W. E. Van Nostrand (1995)
J. Biol. Chem. 270, 26265-26269
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Plasmin Inhibition by a Reactive Center Lysine Mutant of the Kunitz-type Protease Inhibitor Domain of the Amyloid beta-Protein Precursor.

W. E. Van Nostrand, A. H. Schmaier, R. S. Siegel, S. L. Wagner, and W. C. Raschke (1995)
J. Biol. Chem. 270, 22827-22830
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid beta-Protein Aggregation Nullifies Its Pathologic Properties in Cultured Cerebrovascular Smooth Muscle Cells.

J. Davis-Salinas and W. E. Van Nostrand (1995)
J. Biol. Chem. 270, 20887-20890
 |  Abstract »  |  Full Text »  |  PDF »

Proteoglycan-mediated Inhibition of Abeta Proteolysis.

R. Gupta-Bansal, R. C. A. Frederickson, and K. R. Brunden (1995)
J. Biol. Chem. 270, 18666-18671
 |  Abstract »  |  Full Text »  |  PDF »

Nucleolin and Heterogeneous Nuclear Ribonucleoprotein C Proteins Specifically Interact with the 3`-Untranslated Region of Amyloid Protein Precursor mRNA.

S. H. E. Zaidi and J. S. Malter (1995)
J. Biol. Chem. 270, 17292-17298
 |  Abstract »  |  Full Text »  |  PDF »

The Alzheimer Amyloid Precursor Proteoglycan (Appican) Is Present in Brain and Is Produced by Astrocytes but Not by Neurons in Primary Neural Cultures.

J. Shioi, M. N. Pangalos, J. A. Ripellino, D. Vassilacopoulou, C. Mytilineou, R. U. Margolis, and N. K. Robakis (1995)
J. Biol. Chem. 270, 11839-11844
 |  Abstract »  |  Full Text »  |  PDF »

The Chondroitin Sulfate Attachment Site of Appican Is Formed by Splicing Out Exon 15 of the Amyloid Precursor Gene.

M. N. Pangalos, S. Efthimiopoulos, J. Shioi, and N. K. Robakis (1995)
J. Biol. Chem. 270, 10388-10391
 |  Abstract »  |  Full Text »  |  PDF »

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

N Suzuki, T. Cheung, X. Cai, A Odaka, L Otvos Jr, C Eckman, T. Golde, and S. Younkin (1994)
Science 264, 1336-1340
 |  Abstract »  |  PDF »

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

X. Cai, T. Golde, and S. Younkin (1993)
Science 259, 514-516
 |  Abstract »  |  PDF »

Production of the Alzheimer amyloid beta protein by normal proteolytic processing.

M Shoji, T. Golde, J Ghiso, T. Cheung, S Estus, L. Shaffer, X. Cai, D. McKay, R Tintner, B Frangione, et al. (1992)
Science 258, 126-129
 |  Abstract »  |  PDF »

Alzheimer's disease: a cell biological perspective.

K. Kosik (1992)
Science 256, 780-783
 |  Abstract »  |  PDF »

Alzheimer's disease: the amyloid cascade hypothesis.

J. Hardy and G. Higgins (1992)
Science 256, 184-185
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A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease.

J Murrell, M Farlow, B Ghetti, and M. Benson (1991)
Science 254, 97-99
 |  Abstract »  |  PDF »

Deposits of amyloid beta protein in the central nervous system of transgenic mice.

D. Wirak, R Bayney, T. Ramabhadran, R. Fracasso, J. Hart, P. Hauer, P Hsiau, S. Pekar, G. Scangos, B. Trapp, et al. (1991)
Science 253, 323-325
 |  Abstract »  |  PDF »

Radiation hybrid mapping: a somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes.

D. Cox, M Burmeister, E. Price, S Kim, and R. Myers (1990)
Science 250, 245-250
 |  Abstract »  |  PDF »

of Amino Terminal and A4 ({beta}-Amyloid) Antigens in Alzheimer Plaques: Evidence for Coordinated Processing of the Amyloid Precursor Protein.

B. Tate-Ostroff, R. E. Majocha, E. C. Walcott, M. Ventosa-Michelman, and C. A. Marotta (1990)
J Geriatr Psychiatry Neurol 3, 139-145
 |  Abstract »  |  PDF »

Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch).

C Van Broeckhoven, J Haan, E Bakker, J. Hardy, W Van Hul, A Wehnert, M Vegter-Van der Vlis, and R. Roos (1990)
Science 248, 1120-1122
 |  Abstract »  |  PDF »

Cleavage of amyloid beta peptide during constitutive processing of its precursor.

F. Esch, P. Keim, E. Beattie, R. Blacher, A. Culwell, T Oltersdorf, D McClure, and P. Ward (1990)
Science 248, 1122-1124
 |  Abstract »  |  PDF »

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

E Levy, M. Carman, I. Fernandez-Madrid, M. Power, I Lieberburg, S. van Duinen, G. Bots, W Luyendijk, and B Frangione (1990)
Science 248, 1124-1126
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A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein.

F de Sauvage and J. Octave (1989)
Science 245, 651-653
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Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease.

B. Yankner, L. Dawes, S Fisher, L Villa-Komaroff, M. Oster-Granite, and R. Neve (1989)
Science 245, 417-420
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Amyloid beta protein enhances the survival of hippocampal neurons in vitro.

J. Whitson, D. Selkoe, and C. Cotman (1989)
Science 243, 1488-1490
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Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease.

G. Schellenberg, T. Bird, E. Wijsman, D. Moore, M Boehnke, E. Bryant, T. Lampe, D Nochlin, S. Sumi, S. Deeb, et al. (1988)
Science 241, 1507-1510
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Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease.

M. Palmert, T. Golde, M. Cohen, D. Kovacs, R. Tanzi, J. Gusella, M. Usiak, L. Younkin, and S. Younkin (1988)
Science 241, 1080-1084
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Molecular and Genetic Investigations on Alzheimer Brain Amyloid.

R. E. Majocha and C. A. Marotta (1988)
J Geriatr Psychiatry Neurol 1, 65-70
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Gene encoding the beta subunit of S100 protein is on chromosome 21: implications for Down syndrome.

R Allore, D O'Hanlon, R Price, K Neilson, H. Willard, D. Cox, A Marks, and R. Dunn (1988)
Science 239, 1311-1313
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A DNA segment encoding two genes very tightly linked to Huntington's disease.

T. Gilliam, M Bucan, M. MacDonald, M Zimmer, J. Haines, S. Cheng, T. Pohl, R. Meyers, W. Whaley, B. Allitto, et al. (1987)
Science 238, 950-952
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Molecular genetics: applications to the clinical neurosciences.

J. Martin (1987)
Science 238, 765-772
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