Science 20 February 1987: Vol. 235. no. 4791, pp. 877 - 880 DOI: 10.1126/science.3810169

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From the Cover: Small molecule blockers of the Alzheimer A{beta} calcium channel potently protect neurons from A{beta} cytotoxicity.

J. C. Diaz, O. Simakova, K. A. Jacobson, N. Arispe, and H. B. Pollard (2009)
PNAS 106, 3348-3353
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD.

J. Wu, Md. R. Basha, B. Brock, D. P. Cox, F. Cardozo-Pelaez, C. A. McPherson, J. Harry, D. C. Rice, B. Maloney, D. Chen, et al. (2008)
J. Neurosci. 28, 3-9
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{beta}-Amyloid Modulation of Synaptic Transmission and Plasticity.

D. V. Venkitaramani, J. Chin, W. J. Netzer, G. K. Gouras, S. Lesne, R. Malinow, and P. J. Lombroso (2007)
J. Neurosci. 27, 11832-11837
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Down-regulation of Endogenous Amyloid Precursor Protein Processing due to Cellular Aging.

A. Kern, B. Roempp, K. Prager, J. Walter, and C. Behl (2006)
J. Biol. Chem. 281, 2405-2413
 |  Abstract »  |  Full Text »  |  PDF »

An early specific cell-cell interaction occurs in the production of beta-amyloid in cell cultures.

N. N. Dewji, D. Mukhopadhyay, and S. J. Singer (2006)
PNAS 103, 1540-1545
 |  Abstract »  |  Full Text »  |  PDF »

Translational Research on the Way to Effective Therapy for Alzheimer Disease.

R. N. Rosenberg (2005)
Arch Gen Psychiatry 62, 1186-1192
 |  Abstract »  |  Full Text »  |  PDF »

Glycation of the amyloid {beta}-protein by a nicotine metabolite: A fortuitous chemical dynamic between smoking and Alzheimer's disease.

T. J. Dickerson and K. D. Janda (2003)
PNAS 100, 8182-8187
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid {beta}-Protein Stimulates the Expression of Urokinase-type Plasminogen Activator (uPA) and Its Receptor (uPAR) in Human Cerebrovascular Smooth Muscle Cells.

J. Davis, M. R. Wagner, W. Zhang, F. Xu, and W. E. Van Nostrand (2003)
J. Biol. Chem. 278, 19054-19061
 |  Abstract »  |  Full Text »  |  PDF »

Localization of a Fibrillar Amyloid beta -Protein Binding Domain on Its Precursor.

W. E. Van Nostrand, J. P. Melchor, D. M. Keane, S. M. Saporito-Irwin, G. Romanov, J. Davis, and F. Xu (2002)
J. Biol. Chem. 277, 36392-36398
 |  Abstract »  |  Full Text »  |  PDF »

Explaining the Cause of the Amyloid Burden in Alzheimer Disease.

R. N. Rosenberg (2002)
Arch Neurol 59, 1367-1368
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The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics.

J. Hardy and D. J. Selkoe (2002)
Science 297, 353-356
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid Precursor Protein Family-induced Neuronal Death Is Mediated by Impairment of the Neuroprotective Calcium/Calmodulin Protein Kinase IV-dependent Signaling Pathway.

C. Mbebi, V. See, L. Mercken, L. Pradier, U. Muller, and J.-P. Loeffler (2002)
J. Biol. Chem. 277, 20979-20990
 |  Abstract »  |  Full Text »  |  PDF »

Lingering Doubts about Spongiform Encephalopathy and Creutzfeldt-Jakob Disease.

H. K. Narang (2001)
Experimental Biology and Medicine 226, 640-652
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid Precursor Protein in Platelets of Patients With Alzheimer Disease: Effect of Acetylcholinesterase Inhibitor Treatment.

B. Borroni, F. Colciaghi, L. Pastorino, C. Pettenati, E. Cottini, L. Rozzini, R. Monastero, G. L. Lenzi, F. Cattabeni, M. Di Luca, et al. (2001)
Arch Neurol 58, 442-446
 |  Abstract »  |  Full Text »  |  PDF »

Insulysin Hydrolyzes Amyloid beta Peptides to Products That Are Neither Neurotoxic Nor Deposit on Amyloid Plaques.

A. Mukherjee, E.-s. Song, M. Kihiko-Ehmann, J. P. Goodman Jr, J. St. Pyrek, S. Estus, and L. B. Hersh (2000)
J. Neurosci. 20, 8745-8749
 |  Abstract »  |  Full Text »  |  PDF »

The molecular and genetic basis of AD: The end of the beginning: The 2000 Wartenberg lecture.

R. N. Rosenberg (2000)
Neurology 54, 2045-2054
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Role of Phosphorylation of Alzheimer's Amyloid Precursor Protein during Neuronal Differentiation.

K. Ando, M. Oishi, S. Takeda, K.-i. Iijima, T. Isohara, A. C. Nairn, Y. Kirino, P. Greengard, and T. Suzuki (1999)
J. Neurosci. 19, 4421-4427
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of beta -Amyloid Secretion by FE65, an Amyloid Protein Precursor-binding Protein.

S. L. Sabo, L. M. Lanier, A. F. Ikin, O. Khorkova, S. Sahasrabudhe, P. Greengard, and J. D. Buxbaum (1999)
J. Biol. Chem. 274, 7952-7957
 |  Abstract »  |  Full Text »  |  PDF »

The Neurobiology and Pharmacotherapy of Alzheimer's Disease.

O. Felician and T. A. Sandson (1999)
J Neuropsychiatry Clin Neurosci 11, 19-31
 |  Abstract »  |  Full Text »

Interaction of a Neuron-specific Protein Containing PDZ Domains with Alzheimer's Amyloid Precursor Protein.

S. Tomita, T. Ozaki, H. Taru, S. Oguchi, S. Takeda, Y. Yagi, S. Sakiyama, Y. Kirino, and T. Suzuki (1999)
J. Biol. Chem. 274, 2243-2254
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Neurodegenerative Diseases: The Human Illness and Transgenic Models.

D. L. Price, S. S. Sisodia, and D. R. Borchelt (1998)
Science 282, 1079-1083
 |  Abstract »  |  Full Text »

Using Knockout and Transgenic Mice to Study Neurophysiology and Behavior.

M. R. PICCIOTTO and K. WICKMAN (1998)
Physiol Rev 78, 1131-1163
 |  Abstract »  |  Full Text »  |  PDF »

Differential Level of Platelet Amyloid {beta} Precursor Protein Isoforms: An Early Marker for Alzheimer Disease.

M. Di Luca, L. Pastorino, A. Bianchetti, J. Perez, L. A. Vignolo, G. L. Lenzi, M. Trabucchi, F. Cattabeni, and A. Padovani (1998)
Arch Neurol 55, 1195-1200
 |  Abstract »  |  Full Text »  |  PDF »

A Basic Amino Acid in the Cytoplasmic Domain of Alzheimer's beta -Amyloid Precursor Protein (APP) Is Essential for Cleavage of APP at the alpha -Site.

S. Tomita, Y. Kirino, and T. Suzuki (1998)
J. Biol. Chem. 273, 19304-19310
 |  Abstract »  |  Full Text »  |  PDF »

Dramatic Aggregation of Alzheimer Abeta by Cu(II) Is Induced by Conditions Representing Physiological Acidosis.

C. S. Atwood, R. D. Moir, X. Huang, R. C. Scarpa, N. M. E. Bacarra, D. M. Romano, M. A. Hartshorn, R. E. Tanzi, and A. I. Bush (1998)
J. Biol. Chem. 273, 12817-12826
 |  Abstract »  |  Full Text »  |  PDF »

alpha 2-macroglobulin associates with beta -amyloid peptide and prevents fibril formation.

S. R. Hughes, O. Khorkova, S. Goyal, J. Knaeblein, J. Heroux, N. G. Riedel, and S. Sahasrabudhe (1998)
PNAS 95, 3275-3280
 |  Abstract »  |  Full Text »  |  PDF »

Cleavage of Alzheimer's Amyloid Precursor Protein (APP) by Secretases Occurs after O-Glycosylation of APP in the Protein Secretory Pathway. IDENTIFICATION OF INTRACELLULAR COMPARTMENTS IN WHICH APP CLEAVAGE OCCURS WITHOUT USING TOXIC AGENTS THAT INTERFERE WITH PROTEIN METABOLISM.

S. Tomita, Y. Kirino, and T. Suzuki (1998)
J. Biol. Chem. 273, 6277-6284
 |  Abstract »  |  Full Text »  |  PDF »

Relative Increase in Alzheimer's Disease of Soluble Forms of Cerebral Abeta Amyloid Protein Precursor Containing the Kunitz Protease Inhibitory Domain.

R. D. Moir, T. Lynch, A. I. Bush, S. Whyte, A. Henry, S. Portbury, G. Multhaup, D. H. Small, R. E. Tanzi, K. Beyreuther, et al. (1998)
J. Biol. Chem. 273, 5013-5019
 |  Abstract »  |  Full Text »  |  PDF »

Differential Effects of the Swedish Mutant Amyloid Precursor Protein on beta -Amyloid Accumulation and Secretion in Neurons and Nonneuronal Cells.

M. S. Forman, D. G. Cook, S. Leight, R. W. Doms, and V. M.-Y. Lee (1997)
J. Biol. Chem. 272, 32247-32253
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Exploring the Etiology of Alzheimer Disease Using Molecular Genetics.

C. L. Lendon, F. Ashall, and A. M. Goate (1997)
JAMA 277, 825-831
 |  Abstract »  |  PDF »

The Clinical Introduction of Genetic Testing for Alzheimer Disease: An Ethical Perspective.

S. G. Post, P. J. Whitehouse, R. H. Binstock, T. D. Bird, S. K. Eckert, L. A. Farrer, L. M. Fleck, A. D. Gaines, E. T. Juengst, H. Karlinsky, et al. (1997)
JAMA 277, 832-836
 |  Abstract »  |  PDF »

The Profile of Soluble Amyloid beta Protein in Cultured Cell Media. DETECTION AND QUANTIFICATION OF AMYLOID beta PROTEIN AND VARIANTS BY IMMUNOPRECIPITATION-MASS SPECTROMETRY.

R. Wang, D. Sweeney, S. E. Gandy, and S. S. Sisodia (1996)
J. Biol. Chem. 271, 31894-31902
 |  Abstract »  |  Full Text »  |  PDF »

The Alternatively Spliced Kunitz Protease Inhibitor Domain Alters Amyloid beta Protein Precursor Processing and Amyloid beta Protein Production in Cultured Cells.

L. Ho, K.-i. Fukuchi, and StevenG. Younkin (1996)
J. Biol. Chem. 271, 30929-30934
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Amyloidogenic Processing of the beta -Amyloid Precursor Protein in Gene-targeted Mice Bearing the Swedish Familial Alzheimer's Disease Mutations and a ``Humanized'' Abeta Sequence.

A. G. Reaume, D. S. Howland, S. P. Trusko, M. J. Savage, D. M. Lang, B. D. Greenberg, R. Siman, and R. W. Scott (1996)
J. Biol. Chem. 271, 23380-23388
 |  Abstract »  |  Full Text »  |  PDF »

The Initiator Element and Proximal Upstream Sequences Affect Transcriptional Activity and Start Site Selection in the Amyloid beta -Protein Precursor Promoter.

W. W. Quitschke, J. P. Matthews, R. J. Kraus, and A. A. Vostrov (1996)
J. Biol. Chem. 271, 22231-22239
 |  Abstract »  |  Full Text »  |  PDF »

APP-BP1, a Novel Protein That Binds to the Carboxyl-terminal Region of the Amyloid Precursor Protein.

N. Chow, J. R. Korenberg, X.-N. Chen, and R. L. Neve (1996)
J. Biol. Chem. 271, 11339-11346
 |  Abstract »  |  Full Text »  |  PDF »

The Interaction between Apolipoprotein E and Alzheimer's Amyloid beta-Peptide Is Dependent on beta-Peptide Conformation.

A. A. Golabek, C. Soto, T. Vogel, and T. Wisniewski (1996)
J. Biol. Chem. 271, 10602-10606
 |  Abstract »  |  Full Text »  |  PDF »

Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody.

E. Koo, S. Squazzo, D. Selkoe, and C. Koo (1996)
J. Cell Sci. 109, 991-998
 |  Abstract »  |  PDF »

The Role of Presenilin 1 in the Genetics of Alzheimer's Disease.

R.F. Clark, M. Hutton, C. Talbot, M. Wragg, C. Lendon, F. Busfield, S.W. Han, J. Perez-Tur, M. Adams, R. Fuldner, et al. (1996)
Cold Spring Harb Symp Quant Biol 61, 551-558
 |  Abstract »  |  PDF »

Two Homologous Genes Causing Early-onset Familial Alzheimer's Disease.

P.H. St. George-Hyslop, G. Levesque, L. Levesque, J. Rommens, D. Westaway, and P.E. Fraser (1996)
Cold Spring Harb Symp Quant Biol 61, 559-564
 |  Abstract »  |  PDF »

Coagulation Factor XIa Cleaves the RHDS Sequence and Abolishes the Cell Adhesive Properties of the Amyloid beta-Protein.

S. M. Saporito-Irwin and W. E. Van Nostrand (1995)
J. Biol. Chem. 270, 26265-26269
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid beta-Protein Aggregation Nullifies Its Pathologic Properties in Cultured Cerebrovascular Smooth Muscle Cells.

J. Davis-Salinas and W. E. Van Nostrand (1995)
J. Biol. Chem. 270, 20887-20890
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid beta-Protein Inhibits Ubiquitin-dependent Protein Degradation in Vitro.

L. Gregori, C. Fuchs, M. E. Figueiredo-Pereira, W. E. Van Nostrand, and D. Goldgaber (1995)
J. Biol. Chem. 270, 19702-19708
 |  Abstract »  |  Full Text »  |  PDF »

Proteoglycan-mediated Inhibition of Abeta Proteolysis.

R. Gupta-Bansal, R. C. A. Frederickson, and K. R. Brunden (1995)
J. Biol. Chem. 270, 18666-18671
 |  Abstract »  |  Full Text »  |  PDF »

The Alzheimer Amyloid Precursor Proteoglycan (Appican) Is Present in Brain and Is Produced by Astrocytes but Not by Neurons in Primary Neural Cultures.

J. Shioi, M. N. Pangalos, J. A. Ripellino, D. Vassilacopoulou, C. Mytilineou, R. U. Margolis, and N. K. Robakis (1995)
J. Biol. Chem. 270, 11839-11844
 |  Abstract »  |  Full Text »  |  PDF »

The Chondroitin Sulfate Attachment Site of Appican Is Formed by Splicing Out Exon 15 of the Amyloid Precursor Gene.

M. N. Pangalos, S. Efthimiopoulos, J. Shioi, and N. K. Robakis (1995)
J. Biol. Chem. 270, 10388-10391
 |  Abstract »  |  Full Text »  |  PDF »

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

N Suzuki, T. Cheung, X. Cai, A Odaka, L Otvos Jr, C Eckman, T. Golde, and S. Younkin (1994)
Science 264, 1336-1340
 |  Abstract »  |  PDF »

Molecular Genetics of Alzheimer's Disease.

R. F. Clark and A. M. Goate (1993)
Arch Neurol 50, 1164-1172
 |  Abstract »  |  PDF »

Evidence of Subtypes of Alzheimer's Disease and Implications for Etiology.

W. Bondareff, C. Q. Mountjoy, C. M. Wischik, D. L. Hauser, L. D. LaBree, and M. Roth (1993)
Arch Gen Psychiatry 50, 350-356
 |  Abstract »  |  PDF »

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

X. Cai, T. Golde, and S. Younkin (1993)
Science 259, 514-516
 |  Abstract »  |  PDF »

Production of the Alzheimer amyloid beta protein by normal proteolytic processing.

M Shoji, T. Golde, J Ghiso, T. Cheung, S Estus, L. Shaffer, X. Cai, D. McKay, R Tintner, B Frangione, et al. (1992)
Science 258, 126-129
 |  Abstract »  |  PDF »

Alzheimer's disease: a cell biological perspective.

K. Kosik (1992)
Science 256, 780-783
 |  Abstract »  |  PDF »

Alzheimer's disease: the amyloid cascade hypothesis.

J. Hardy and G. Higgins (1992)
Science 256, 184-185
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Amyloid Filaments in Inclusion Body Myositis: Novel Findings Provide Insight Into Nature of Filaments.

J. R. Mendell, Z. Sahenk, T. Gales, and L. Paul (1991)
Arch Neurol 48, 1229-1234
 |  Abstract »  |  PDF »

Clinical Genetics and Genetic Counseling in Alzheimer Disease.

J. C. S. Breitner (1991)
Ann Intern Med 115, 601-606
 |  Abstract »  |  PDF »

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease.

J Murrell, M Farlow, B Ghetti, and M. Benson (1991)
Science 254, 97-99
 |  Abstract »  |  PDF »

Deposits of amyloid beta protein in the central nervous system of transgenic mice.

D. Wirak, R Bayney, T. Ramabhadran, R. Fracasso, J. Hart, P. Hauer, P Hsiau, S. Pekar, G. Scangos, B. Trapp, et al. (1991)
Science 253, 323-325
 |  Abstract »  |  PDF »

Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition.

C. Barrow and M. Zagorski (1991)
Science 253, 179-182
 |  Abstract »  |  PDF »

of Amino Terminal and A4 ({beta}-Amyloid) Antigens in Alzheimer Plaques: Evidence for Coordinated Processing of the Amyloid Precursor Protein.

B. Tate-Ostroff, R. E. Majocha, E. C. Walcott, M. Ventosa-Michelman, and C. A. Marotta (1990)
J Geriatr Psychiatry Neurol 3, 139-145
 |  Abstract »  |  PDF »

Cleavage of amyloid beta peptide during constitutive processing of its precursor.

F. Esch, P. Keim, E. Beattie, R. Blacher, A. Culwell, T Oltersdorf, D McClure, and P. Ward (1990)
Science 248, 1122-1124
 |  Abstract »  |  PDF »

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

E Levy, M. Carman, I. Fernandez-Madrid, M. Power, I Lieberburg, S. van Duinen, G. Bots, W Luyendijk, and B Frangione (1990)
Science 248, 1124-1126
 |  Abstract »  |  PDF »

Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein.

W. Van Nostrand, A. Schmaier, J. Farrow, and D. Cunningham (1990)
Science 248, 745-748
 |  Abstract »  |  PDF »

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing.

S. Sisodia, E. Koo, K Beyreuther, A Unterbeck, and D. Price (1990)
Science 248, 492-495
 |  Abstract »  |  PDF »

A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein.

F de Sauvage and J. Octave (1989)
Science 245, 651-653
 |  Abstract »  |  PDF »

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease.

B. Yankner, L. Dawes, S Fisher, L Villa-Komaroff, M. Oster-Granite, and R. Neve (1989)
Science 245, 417-420
 |  Abstract »  |  PDF »

Amyloid beta protein enhances the survival of hippocampal neurons in vitro.

J. Whitson, D. Selkoe, and C. Cotman (1989)
Science 243, 1488-1490
 |  Abstract »  |  PDF »

The Molecular Genetic Revolution: Its Impact on Clinical Neurology.

C. S. Payne and A. D. Roses (1988)
Arch Neurol 45, 1366-1376
 |  Abstract »  |  PDF »

Alois Alzheimer on Presenile Dementia.

J. Tonkonogy and G. S. Moak (1988)
J Geriatr Psychiatry Neurol 1, 199-206
 |  Abstract »  |  PDF »

Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease.

G. Schellenberg, T. Bird, E. Wijsman, D. Moore, M Boehnke, E. Bryant, T. Lampe, D Nochlin, S. Sumi, S. Deeb, et al. (1988)
Science 241, 1507-1510
 |  Abstract »  |  PDF »

Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease.

M. Palmert, T. Golde, M. Cohen, D. Kovacs, R. Tanzi, J. Gusella, M. Usiak, L. Younkin, and S. Younkin (1988)
Science 241, 1080-1084
 |  Abstract »  |  PDF »

Brain Amyloid and Alzheimer Disease.

H. V. Vinters, B. L. Miller, and W. M. Pardridge (1988)
Ann Intern Med 109, 41-54
 |  Abstract »  |  PDF »

Molecular and Genetic Investigations on Alzheimer Brain Amyloid.

R. E. Majocha and C. A. Marotta (1988)
J Geriatr Psychiatry Neurol 1, 65-70
 |  Abstract »  |  PDF »

Molecular genetics: applications to the clinical neurosciences.

J. Martin (1987)
Science 238, 765-772
 |  Abstract »  |  PDF »

Gene dosage of the amyloid beta precursor protein in Alzheimer's disease.

M. Podlisny, G Lee, and D. Selkoe (1987)
Science 238, 669-671
 |  Abstract »  |  PDF »

erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation.

V. Rao, T. Papas, and E. Reddy (1987)
Science 237, 635-639
 |  Abstract »  |  PDF »

Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimer's disease.

S Bahmanyar, G. Higgins, D Goldgaber, D. Lewis, J. Morrison, M. Wilson, S. Shankar, and D. Gajdusek (1987)
Science 237, 77-80
 |  Abstract »  |  PDF »

Beta amyloid gene duplication in Alzheimer's disease and karyotypically normal Down syndrome.

J. Delabar, D Goldgaber, Y Lamour, A Nicole, J. Huret, J de Grouchy, P Brown, D. Gajdusek, and P. Sinet (1987)
Science 235, 1390-1392
 |  Abstract »  |  PDF »

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

R. Tanzi, J. Gusella, P. Watkins, G. Bruns, P St George-Hyslop, M. Van Keuren, D Patterson, S Pagan, D. Kurnit, and R. Neve (1987)
Science 235, 880-884
 |  Abstract »  |  PDF »

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