Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Scarab Genomics

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 13 February 1987:
Vol. 235. no. 4790, pp. 787 - 789
DOI: 10.1126/science.3810165
Prev | Table of Contents | Next

Articles

Science, Vol 235, Issue 4790, 787-789
Copyright © 1987 by American Association for the Advancement of Science

articles

Avian v-myc replaces chromosomal translocation in murine plasmacytomagenesis

M Potter, JF Mushinski, EB Mushinski, S Brust, JS Wax, F Wiener, M Babonits, UR Rapp, and HC Morse 3rd

Deregulation of c-myc expression in association with chromosomal translocations occurs in over 95% of murine plasmacytomas, rat immunocytomas, and human Burkitt lymphomas. Infection with a murine retrovirus (J-3) containing an avian v-myc rapidly induced plasmacytomas in pristane-primed BALB/cAn mice. Only 17% of the induced plasmacytomas that were karyotyped showed the characteristic chromosomal translocations involving the c-myc locus. Instead, all of the translocation-negative tumors demonstrated characteristic J-3 virus integration sites that were actively transcribed. Thus, the high levels of v-myc expression have replaced the requirement for chromosomal translocation in plasmacytomagenesis and accelerated the process of transformation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Insertion of Myc into Igh Accelerates Peritoneal Plasmacytomas in Mice.
S. S. Park, A. L. Shaffer, J. S. Kim, W. duBois, M. Potter, L. M. Staudt, and S. Janz (2005)
Cancer Res. 65, 7644-7652
   Abstract »    Full Text »    PDF »
Murine plasmacytomas, carrier of the t(12;15) chromosomal translocation, develop from immature/mature B cells not from differentiated plasma cells.
S. Ohno, J.-i. Hayakawa, N. Hashimoto, and F. Wiener (1999)
Carcinogenesis 20, 529-538
   Abstract »    Full Text »    PDF »
The approaching era of the tumor suppressor genes.
G Klein (1987)
Science 238, 1539-1545
   Abstract »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)