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Science 23 January 1987: Vol. 235. no. 4787, pp. 442 - 447 DOI: 10.1126/science.2432664
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Articles
Science, Vol 235, Issue 4787, 442-447
Copyright © 1987 by American Association for the Advancement of Science
Angiogenic factors
J Folkman
and
M Klagsbrun
Within the past 2 years, several angiogenic factors have been fully purified, their amino acid sequences determined, and their genes cloned. These polypeptides include acidic and basic fibroblast growth factor, angiogenin, and transforming growth factors alpha and beta. Other less well characterized angiogenesis factors have also been isolated, some of which are lipids. This article traces the discovery of the angiogenic factors and describes their possible significance in understanding growth regulation of the vascular system. When evaluated according to their putative targets, they appear to fall into two groups: those that act directly on vascular endothelial cells to stimulate locomotion or mitosis, and those that act indirectly by mobilizing host cells (for example, macrophages) to release endothelial growth factors. In addition to their presence in tumors undergoing neovascularization, the same angiogenic peptides are found in many normal tissues where neovascularization is not occurring. This suggests that physiological expression of angiogenic factors is tightly regulated. In addition to the persistent angiogenesis induced by tumors, it now appears that a variety of nonneoplastic diseases, previously thought to be unrelated, can be considered as "angiogenic diseases" because they are dominated by the pathologic growth of capillary blood vessels.
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- Inhibitory Effect of the Salmosin Gene Transferred by Cationic Liposomes on the Progression of B16BL6 Tumors.
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Cancer Res.
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- The Combination of the Tyrosine Kinase Receptor Inhibitor SU6668 with Paclitaxel Affects Ascites Formation and Tumor Spread in Ovarian Carcinoma Xenografts Growing Orthotopically.
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Clin. Cancer Res.
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- Heavy Ion Irradiation Inhibits in Vitro Angiogenesis Even at Sublethal Dose.
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Cancer Res.
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- The relationship between transplacental O2 diffusion and placental expression of PlGF, VEGF and their receptors in a placental insufficiency model of fetal growth restriction.
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J. Physiol.
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- Toward surgical angiogenesis using slow-released basic fibroblast growth factor.
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Eur. J. Cardiothorac. Surg.
24, 105-112
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- Modulation of placental vascular endothelial growth factor by leptin and hCG.
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Mol. Hum. Reprod.
9, 395-398
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- Intravenous Delivery of Adenovirus-mediated Soluble FLT-1 Results in Liver Toxicity.
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Clin. Cancer Res.
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- Exercise but not prostanoids enhance levels of vascular endothelial growth factor and other proliferative agents in human skeletal muscle interstitium.
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J. Physiol.
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- Leads for Development of New Naphthalenesulfonate Derivatives with Enhanced Antiangiogenic Activity: CRYSTAL STRUCTURE OF ACIDIC FIBROBLAST GROWTH FACTOR IN COMPLEX WITH 5-AMINO-2-NAPHTHALENESULFONATE.
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J. Biol. Chem.
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- Distinct Role of Fibroblast Growth Factor-2 and Vascular Endothelial Growth Factor on Tumor Growth and Angiogenesis.
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Am. J. Pathol.
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- Small Peripheral Pulmonary Carcinomas Evaluated with Dynamic MR Imaging: Correlation with Tumor Vascularity and Prognosis.
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Radiology
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- Expression and Localization of Tenomodulin, a Transmembrane Type Chondromodulin-I-Related Angiogenesis Inhibitor, in Mouse Eyes.
- Y. Oshima, C. Shukunami, J. Honda, K. Nishida, F. Tashiro, J.-i. Miyazaki, Y. Hiraki, and Y. Tano (2003)
Invest. Ophthalmol. Vis. Sci.
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- Angiogenesis: basic pathophysiology and implications for disease.
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Eur. Heart J.
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- Complex Regulation of the Fibroblast Growth Factor-binding Protein in MDA- MB-468 Breast Cancer Cells by CCAAT/Enhancer-binding Protein {beta}.
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Cancer Res.
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- Levels of Soluble Vascular Endothelial Growth Factor (VEGF) Receptor 1 in Astrocytic Tumors and Its Relation to Malignancy, Vascularity, and VEGF-A.
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- Thrombosis Increases Circulatory Hepatocyte Growth Factor by Degranulation of Mast Cells.
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Circulation
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- A Truncated Plasminogen Activator Inhibitor-1 Protein Blocks the Availability of Heparin-binding Vascular Endothelial Growth Factor A Isoforms.
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- Cancer Therapy With Tetrathiomolybdate: Antiangiogenesis by Lowering Body Copper--A Review.
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Integr Cancer Ther
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- Characterization of Human Chorionic Gonadotropin as a Novel Angiogenic Factor.
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- Guanylate-Binding Protein-1 Expression Is Selectively Induced by Inflammatory Cytokines and Is an Activation Marker of Endothelial Cells during Inflammatory Diseases.
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