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Science 23 January 1987:
Vol. 235. no. 4787, pp. 442 - 447
DOI: 10.1126/science.2432664

Articles

Science, Vol 235, Issue 4787, 442-447
Copyright © 1987 by American Association for the Advancement of Science


articles

Angiogenic factors

J Folkman and M Klagsbrun

Within the past 2 years, several angiogenic factors have been fully purified, their amino acid sequences determined, and their genes cloned. These polypeptides include acidic and basic fibroblast growth factor, angiogenin, and transforming growth factors alpha and beta. Other less well characterized angiogenesis factors have also been isolated, some of which are lipids. This article traces the discovery of the angiogenic factors and describes their possible significance in understanding growth regulation of the vascular system. When evaluated according to their putative targets, they appear to fall into two groups: those that act directly on vascular endothelial cells to stimulate locomotion or mitosis, and those that act indirectly by mobilizing host cells (for example, macrophages) to release endothelial growth factors. In addition to their presence in tumors undergoing neovascularization, the same angiogenic peptides are found in many normal tissues where neovascularization is not occurring. This suggests that physiological expression of angiogenic factors is tightly regulated. In addition to the persistent angiogenesis induced by tumors, it now appears that a variety of nonneoplastic diseases, previously thought to be unrelated, can be considered as "angiogenic diseases" because they are dominated by the pathologic growth of capillary blood vessels.


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Toward surgical angiogenesis using slow-released basic fibroblast growth factor.
Y. Sakakibara, K. Tambara, G. Sakaguchi, F. Lu, M. Yamamoto, K. Nishimura, Y. Tabata, and M. Komeda (2003)
Eur. J. Cardiothorac. Surg. 24, 105-112
   Abstract »    Full Text »    PDF »
Modulation of placental vascular endothelial growth factor by leptin and hCG.
D. Islami, P. Bischof, and D. Chardonnens (2003)
Mol. Hum. Reprod. 9, 395-398
   Abstract »    Full Text »    PDF »
Intravenous Delivery of Adenovirus-mediated Soluble FLT-1 Results in Liver Toxicity.
P. J. Mahasreshti, M. Kataram, M. H. Wang, C. R. Stockard, W. E. Grizzle, D. Carey, G. P. Siegal, H. J. Haisma, R. D. Alvarez, and D. T. Curiel (2003)
Clin. Cancer Res. 9, 2701-2710
   Abstract »    Full Text »    PDF »
Exercise but not prostanoids enhance levels of vascular endothelial growth factor and other proliferative agents in human skeletal muscle interstitium.
L. Hoffner, J. J. Nielsen, H. Langberg, and Y. Hellsten (2003)
J. Physiol. 550, 217-225
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Leads for Development of New Naphthalenesulfonate Derivatives with Enhanced Antiangiogenic Activity: CRYSTAL STRUCTURE OF ACIDIC FIBROBLAST GROWTH FACTOR IN COMPLEX WITH 5-AMINO-2-NAPHTHALENESULFONATE.
C. Fernandez-Tornero, R. M. Lozano, M. Redondo-Horcajo, A. M. Gomez, J. C. Lopez, E. Quesada, C. Uriel, S. Valverde, P. Cuevas, A. Romero, et al. (2003)
J. Biol. Chem. 278, 21774-21781
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Distinct Role of Fibroblast Growth Factor-2 and Vascular Endothelial Growth Factor on Tumor Growth and Angiogenesis.
R. Giavazzi, B. Sennino, D. Coltrini, A. Garofalo, R. Dossi, R. Ronca, M. P. M. Tosatti, and M. Presta (2003)
Am. J. Pathol. 162, 1913-1926
   Abstract »    Full Text »    PDF »
Small Peripheral Pulmonary Carcinomas Evaluated with Dynamic MR Imaging: Correlation with Tumor Vascularity and Prognosis.
K. Fujimoto, T. Abe, N. L. Muller, H. Terasaki, S. Kato, J. Sadohara, R. Kono, O. Edamitsu, T. Ishitake, A. Hayashi, et al. (2003)
Radiology 227, 786-793
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Expression and Localization of Tenomodulin, a Transmembrane Type Chondromodulin-I-Related Angiogenesis Inhibitor, in Mouse Eyes.
Y. Oshima, C. Shukunami, J. Honda, K. Nishida, F. Tashiro, J.-i. Miyazaki, Y. Hiraki, and Y. Tano (2003)
Invest. Ophthalmol. Vis. Sci. 44, 1814-1823
   Abstract »    Full Text »    PDF »
Angiogenesis: basic pathophysiology and implications for disease.
D.C Felmeden, A.D Blann, and G.Y.H Lip (2003)
Eur. Heart J. 24, 586-603
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Complex Regulation of the Fibroblast Growth Factor-binding Protein in MDA- MB-468 Breast Cancer Cells by CCAAT/Enhancer-binding Protein {beta}.
B. L. Kagan, R. T. Henke, R. Cabal-Manzano, G. E. Stoica, Q. Nguyen, A. Wellstein, and A. T. Riegel (2003)
Cancer Res. 63, 1696-1705
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Levels of Soluble Vascular Endothelial Growth Factor (VEGF) Receptor 1 in Astrocytic Tumors and Its Relation to Malignancy, Vascularity, and VEGF-A.
K. Lamszus, U. Ulbricht, J. Matschke, M. A. Brockmann, R. Fillbrandt, and M. Westphal (2003)
Clin. Cancer Res. 9, 1399-1405
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Thrombosis Increases Circulatory Hepatocyte Growth Factor by Degranulation of Mast Cells.
M. Kinoshita, T. Miyamoto, N. Ohashi, S. Sasayama, and A. Matsumori (2002)
Circulation 106, 3133-3138
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A Truncated Plasminogen Activator Inhibitor-1 Protein Blocks the Availability of Heparin-binding Vascular Endothelial Growth Factor A Isoforms.
M. J. Mulligan-Kehoe, H. K. Kleinman, M. Drinane, R. J. Wagner, C. Wieland, and R. J. Powell (2002)
J. Biol. Chem. 277, 49077-49089
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Cancer Therapy With Tetrathiomolybdate: Antiangiogenesis by Lowering Body Copper--A Review.
G. J. Brewer and S. D. Merajver (2002)
Integr Cancer Ther 1, 327-337
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Characterization of Human Chorionic Gonadotropin as a Novel Angiogenic Factor.
M. Zygmunt, F. Herr, S. Keller-Schoenwetter, K. Kunzi-Rapp, K. Munstedt, C. V. Rao, U. Lang, and K. T. Preissner (2002)
J. Clin. Endocrinol. Metab. 87, 5290-5296
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