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Science 16 January 1987:
Vol. 235. no. 4786, pp. 334 - 337
DOI: 10.1126/science.3026049
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Articles

Science, Vol 235, Issue 4786, 334-337
Copyright © 1987 by American Association for the Advancement of Science

articles

Myosin rod phosphorylation and the catch state of molluscan muscles

L Castellani and C Cohen

"Catch" is a prolonged state of tension in molluscan smooth muscles shown by mechanical measurements to be associated with the level of protein phosphorylation. Myosin isolated from these muscles is unusual in being phosphorylated in the rod portion by an endogenous kinase, like certain nonmuscle myosins. These findings suggest that the myosin rod is a target for phosphorylation and that this reaction may control the transition from catch to relaxation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Unphosphorylated twitchin forms a complex with actin and myosin that may contribute to tension maintenance in catch.
D. Funabara, C. Hamamoto, K. Yamamoto, A. Inoue, M. Ueda, R. Osawa, S. Kanoh, D. J. Hartshorne, S. Suzuki, and S. Watabe (2007)
J. Exp. Biol. 210, 4399-4410
   Abstract »    Full Text »    PDF »
Invertebrate Muscles: Muscle Specific Genes and Proteins.
S. L. Hooper and J. B. Thuma (2005)
Physiol Rev 85, 1001-1060
   Abstract »    Full Text »    PDF »
Phosphorylation of a twitchin-related protein controls catch and calcium sensitivity of force production in invertebrate smooth muscle.
M. J. Siegman, D. Funabara, S. Kinoshita, S. Watabe, D. J. Hartshorne, and T. M. Butler (1998)
PNAS 95, 5383-5388
   Abstract »    Full Text »    PDF »
An in vitro assay reveals essential protein components for the "catch" state of invertebrate smooth muscle.
A. Yamada, M. Yoshio, H. Kojima, and K. Oiwa (2001)
PNAS 98, 6635-6640
   Abstract »    Full Text »    PDF »


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