Related Content
Search Google Scholar for:
|
|
Science 16 January 1987:
Vol. 235. no. 4786, pp. 321 - 324
DOI: 10.1126/science.3492043
|
|
Articles
Science, Vol 235, Issue 4786, 321-324
Copyright © 1987 by American Association for the Advancement of Science
Construction of a novel oncogene based on synthetic sequences encoding epidermal growth factor
DF Stern,
DL Hare,
MA Cecchini,
and
RA Weinberg
The autocrine model postulates that constitutive release of a mitogenic growth factor can lead to uncontrolled proliferation and cell transformation. A synthetic polynucleotide encoding epidermal growth factor conferred a tumorigenic phenotype on cells. These cells were transformed through the action of an autocrine circuit having an extracellular component.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Epidermal Growth Factor Gene Functional Polymorphism and the Risk of Hepatocellular Carcinoma in Patients With Cirrhosis.
- K. K. Tanabe, A. Lemoine, D. M. Finkelstein, H. Kawasaki, T. Fujii, R. T. Chung, G. Y. Lauwers, Y. Kulu, A. Muzikansky, D. Kuruppu, et al. (2008)
JAMA
299, 53-60
| Abstract »
| Full Text »
| PDF »
- Retroviral vectors preloaded with a viral receptor-ligand bridge protein are targeted to specific cell types.
- A. L. Boerger, S. Snitkovsky, and J. A. T. Young (1999)
PNAS
96, 9867-9872
| Abstract »
| Full Text »
| PDF »
- Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation.
- S.-l. Fu, I. Bottoli, M. Goller, and P. K. Vogt (1999)
PNAS
96, 5716-5721
| Abstract »
| Full Text »
| PDF »
- Cell-specific viral targeting mediated by a soluble retroviral receptor-ligand fusion protein.
- S. Snitkovsky and J. A. T. Young (1998)
PNAS
95, 7063-7068
| Abstract »
| Full Text »
| PDF »
- Interactions within the Yeast Sm Core Complex: from Proteins to Amino Acids.
- A. Camasses, E. Bragado-Nilsson, R. Martin, B. Séraphin, and R. Bordonné (1998)
Mol. Cell. Biol.
18, 1956-1966
| Abstract »
| Full Text »
- Evidence for the Participation of Interleukin-2 (IL-2) and IL-4 in the Regulation of Autonomous Growth and Tumorigenesis of Transformed Cells of Lymphoid Origin.
- M. R. Hassuneh, P. S. Nagarkatti, and M. Nagarkatti (1997)
Blood
89, 610-620
| Abstract »
| Full Text »
| PDF »
- Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes..
- S A McCarthy, M L Samuels, C A Pritchard, J A Abraham, and M McMahon (1995)
Genes & Dev.
9, 1953-1964
| Abstract »
| PDF »
- The Role of Phosphotyrosine Signaling Pathway in Parotid Gland Proliferation and Function.
- K.R. Purushotham and M.G. Humphreys-Beher (1995)
Critical Reviews in Oral Biology & Medicine
6, 119-131
| Abstract »
| Full Text »
| PDF »
- A specific inhibitor of the epidermal growth factor receptor tyrosine kinase.
- D. Fry, A. Kraker, A McMichael, L. Ambroso, J. Nelson, W. Leopold, R. Connors, and A. Bridges (1994)
Science
265, 1093-1095
| Abstract »
| PDF »
- Role of Intrinsic Protein Tyrosine Kinase in Function and Metabolism of the Epidermal Growth Factor Receptor.
- G.N. Gill, W.S. Chen, C.S. Lazar, J.R. Glenney Jr., H.S. Wiley, H.A. Ingraham, and M.G. Rosenfeld (1988)
Cold Spring Harb Symp Quant Biol
53, 467-476
| Abstract »
| PDF »
- Influence of p21ras on Phosphatidylinositol Turnover.
- J. Downward and R.A. Weinberg (1988)
Cold Spring Harb Symp Quant Biol
53, 883-892
| Abstract »
| PDF »
- Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene.
- T. Velu, L Beguinot, W. Vass, M. Willingham, G. Merlino, I Pastan, and D. Lowy (1987)
Science
238, 1408-1410
| Abstract »
| PDF »
|
|
