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Science 16 January 1987:
Vol. 235. no. 4786, pp. 305 - 311
DOI: 10.1126/science.3541204

Articles

Science, Vol 235, Issue 4786, 305-311
Copyright © 1987 by American Association for the Advancement of Science


articles

The molecular genetics of cancer

JM Bishop

The search for genetic damage in neoplastic cells now occupies a central place in cancer research. Diverse examples of such damage are in hand, and they in turn hint at biochemical explanations for neoplastic growth. The way may be open to solve the riddles of how normal cells govern their replication and why cancer cells do not.


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Molecular Aspects of Melanocytic Dysplastic Nevi.
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Forskolin-mediated G1 arrest in acute lymphoblastic leukaemia cells: phosphorylated pRB sequesters E2Fs.
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J. Cell Sci. 115, 1073-1082
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Differentiation Genes: Are They Primary Targets for Human Carcinogenesis?.
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Cancer of Unknown Primary Origin.
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Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis..
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Transcription-Factor Mutations and Disease.
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bcl-2 Expression in Primary Malignancies of the Skin.
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Rising Primary Malignant Brain Tumor Mortality in the Elderly: A Manifestation of Differential Survival.
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Tyrosine kinase inhibition: an approach to drug development.
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Reversion of the mouse pink-eyed unstable mutation induced by low doses of x-rays.
R. Schiestl, F Khogali, and N Carls (1994)
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Molecular Dosimetry of DNA Damage Induced by Polycyclic Aromatic Hydrocarbons; Relevance for Exposure Monitoring and Risk Assessment.
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Temporal and spatial regulation of the expression of BAD2, a MAP kinase phosphatase, during seizure, kindling, and long-term potentiation..
Z Qian, M Gilbert, and E R Kandel (1994)
Learn. Mem. 1, 180-188
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Molecular Screening: Prospects for a New Approach.
D. Sidransky, J. Boyle, and W. Koch (1993)
Arch Otolaryngol Head Neck Surg 119, 1187-1190
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Sister chromatid fusion initiates amplification of the dihydrofolate reductase gene in Chinese hamster cells..
C Ma, S Martin, B Trask, and J L Hamlin (1993)
Genes & Dev. 7, 605-620
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Betacellulin: a mitogen from pancreatic beta cell tumors.
Y Shing, G Christofori, D Hanahan, Y Ono, R Sasada, K Igarashi, and J Folkman (1993)
Science 259, 1604-1607
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Loss of Chromosomal Integrity in Neoplasia.
T.D. Tlsty, P. Jonczyk, A White, M. Sage, I. Hall, D. Schaefer, A. Briot, E. Livanos, H. Roelofs, B. Poulose, et al. (1993)
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An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence..
N Benvenisty, A Leder, A Kuo, and P Leder (1992)
Genes & Dev. 6, 2513-2523
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Suppression of gene amplification in human cell hybrids.
T. Tlsty, A White, and J Sanchez (1992)
Science 255, 1425-1427
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Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes.
E. Fischer, H Charbonneau, and N. Tonks (1991)
Science 253, 401-406
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Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.
K. Kinzler, M. Nilbert, B Vogelstein, T. Bryan, D. Levy, K. Smith, A. Preisinger, Hamilton SR, P Hedge, A Markham, et al. (1991)
Science 251, 1366-1370
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A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration..
B Windle, B W Draper, Y X Yin, S O'Gorman, and G M Wahl (1991)
Genes & Dev. 5, 160-174
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Genetic mechanisms of tumor suppression by the human p53 gene.
P. Chen, Y. Chen, R Bookstein, and W. Lee (1990)
Science 250, 1576-1580
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Oncogene Amplification in Squamous Cell Carcinoma of the Head and Neck.
W. D. Merritt, M. C. Weissler, B. F. Turk, and T. M. Gilmer (1990)
Arch Otolaryngol Head Neck Surg 116, 1394-1398
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Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia.
K. Guan and J. Dixon (1990)
Science 249, 553-556
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Identification of small clusters of divergent amino acids that mediate the opposing effects of ras and Krev-1.
K Zhang, M Noda, W. Vass, A. Papageorge, and D. Lowy (1990)
Science 249, 162-165
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Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development..
D Martin-Zanca, M Barbacid, and L F Parada (1990)
Genes & Dev. 4, 683-694
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c-Ha-ras and UV Photocarcinogenesis: Do Rays Raise ras?.
J. T. Elder (1990)
Arch Dermatol 126, 379-382
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Identification of a chromosome 18q gene that is altered in colorectal cancers.
E. Fearon, K. Cho, J. Nigro, S. Kern, J. Simons, J. Ruppert, Hamilton SR, A. Preisinger, G Thomas, K. Kinzler, et al. (1990)
Science 247, 49-56
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Transgenic mice as probes into complex systems.
D Hanahan (1989)
Science 246, 1265-1275
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Early dihydrofolate reductase gene amplification events in CHO cells usually occur on the same chromosome arm as the original locus..
B J Trask and J L Hamlin (1989)
Genes & Dev. 3, 1913-1925
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Checkpoints: controls that ensure the order of cell cycle events.
L. Hartwell and T. Weinert (1989)
Science 246, 629-634
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Fibroblasts transformed with v-src show enhanced formation of an inositol tetrakisphosphate.
R. Johnson, W. Wasilenko, R. Mattingly, M. Weber, and J. Garrison (1989)
Science 246, 121-124
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Environmental Exposures in Cytogenetically Defined Subsets of Acute Nonlymphocytic Leukemia.
M. M. Crane, M. J. Keating, J. M. Trujillo, D. R. Labarthe, and R. F. Frankowski (1989)
JAMA 262, 634-639
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Perturbed development of the mouse lens by polyomavirus large T antigen does not lead to tumor formation..
A E Griep, T Kuwabara, E J Lee, and H Westphal (1989)
Genes & Dev. 3, 1075-1085
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Healing, Regeneration, and Repair: Prospectus for New Dental Treatment.
V.P. Terranova, M. Jendresen, and F. Young (1989)
Advances in Dental Research 3, 69-79
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Immunosurveillance of Virus-induced Tumors.
C.J.M. Melief, W.L.E. Vasmel, R. Offringa, E.J.A.M. Sijts, E.A. Matthews, P.J. Peters, R.H. Meloen, A.J. van der Eb, and W.M. Kast (1989)
Cold Spring Harb Symp Quant Biol 54, 597-603
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Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells.
H. Huang, J. Yee, J. Shew, P. Chen, R Bookstein, T Friedmann, E. Lee, and W. Lee (1988)
Science 242, 1563-1566
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DNA diagnostics--molecular techniques and automation.
U Landegren, R Kaiser, C. Caskey, and L Hood (1988)
Science 242, 229-237
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Inactivation of the retinoblastoma susceptibility gene in human breast cancers.
E. Lee, H To, J. Shew, R Bookstein, P Scully, and W. Lee (1988)
Science 241, 218-221
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Retroviruses.
H Varmus (1988)
Science 240, 1427-1435
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Transgenic animals.
R Jaenisch (1988)
Science 240, 1468-1474
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Voltage-sensitive calcium channels in normal and transformed 3T3 fibroblasts.
C. Chen, M. Corbley, T. Roberts, and P Hess (1988)
Science 239, 1024-1026
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Role of Intrinsic Protein Tyrosine Kinase in Function and Metabolism of the Epidermal Growth Factor Receptor.
G.N. Gill, W.S. Chen, C.S. Lazar, J.R. Glenney Jr., H.S. Wiley, H.A. Ingraham, and M.G. Rosenfeld (1988)
Cold Spring Harb Symp Quant Biol 53, 467-476
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Regulation of Proto-oncogene fos: A Paradigm for Early Response Genes.
P. Sassone-Corsi, W.W. Lamph, and I.M. Verma (1988)
Cold Spring Harb Symp Quant Biol 53, 749-760
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Characterization of p47gag-crk, a Novel Oncogene Product with Sequence Similarity to a Putative Modulatory Domain of Protein-Tyrosine Kinases and Phospholipase C.
B.J. Mayer, M. Hamaguchi, and H. Hanafusa (1988)
Cold Spring Harb Symp Quant Biol 53, 907-914
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A novel putative tyrosine kinase receptor encoded by the eph gene.
H Hirai, Y Maru, K Hagiwara, J Nishida, and F Takaku (1987)
Science 238, 1717-1720
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The approaching era of the tumor suppressor genes.
G Klein (1987)
Science 238, 1539-1545
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Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.
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Science 238, 1386-1392
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Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene.
T. Velu, L Beguinot, W. Vass, M. Willingham, G. Merlino, I Pastan, and D. Lowy (1987)
Science 238, 1408-1410
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Defects in lens fiber differentiation are linked to c-mos overexpression in transgenic mice..
J S Khillan, M K Oskarsson, F Propst, T Kuwabara, G F Vande Woude, and H Westphal (1987)
Genes & Dev. 1, 1327-1335
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Rapid stimulation of diacylglycerol production in Xenopus oocytes by microinjection of H-ras p21.
J. Lacal, P de la Pena, J Moscat, P Garcia-Barreno, P. Anderson, and S. Aaronson (1987)
Science 238, 533-536
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Disease diagnosis by recombinant DNA methods.
C. Caskey (1987)
Science 236, 1223-1229
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Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors.
D. Burke, G. Carle, and M. Olson (1987)
Science 236, 806-812
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Introduction of a normal human chromosome 11 into a Wilms' tumor cell line controls its tumorigenic expression.
B. Weissman, P. Saxon, Pasquale SR, G. Jones, A. Geiser, and E. Stanbridge (1987)
Science 236, 175-180
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Human retinoblastoma susceptibility gene: cloning, identification, and sequence.
W. Lee, R Bookstein, F Hong, L. Young, J. Shew, and E. Lee (1987)
Science 235, 1394-1399
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Characterization of a Prostate-specific Tyrosine Phosphatase by Mutagenesis and Expression in Human Prostate Cancer Cells.
X.-Q. Zhang, M.-S. Lee, S. Zelivianski, and M.-F. Lin (2001)
J. Biol. Chem. 276, 2544-2550
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Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks.
M. J. Singer, L. D. Mesner, C. L. Friedman, B. J. Trask, and J. L. Hamlin (2000)
PNAS 97, 7921-7926
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