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Science 9 January 1987:
Vol. 235. no. 4785, pp. 220 - 222
DOI: 10.1126/science.2432661
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Articles

Science, Vol 235, Issue 4785, 220-222
Copyright © 1987 by American Association for the Advancement of Science

articles

Preferred microtubules for vesicle transport in lobster axons

RH Miller, RJ Lasek, and MJ Katz

The hypothesis that transported vesicles are preferentially associated with a subclass of microtubules has been tested in lobster axons. A cold block was used to collect moving vesicles in these axons; this treatment caused the vesicles to accumulate in files along some of the microtubules. Quantitative analysis of the number of vesicles associated with microtubule segments indicated that lobster axons have two distinct populations of microtubules--transport microtubules that are the preferred substrates for vesicle transport and architectural microtubules that contribute to axonal structure.


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Long-range cooperative binding of kinesin to a microtubule in the presence of ATP.
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Neurofilaments Are Nonessential to the Pathogenesis of Toxicant-Induced Axonal Degeneration.
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Interaction of Kinesin Motor Domains with alpha - and beta -Tubulin Subunits at a Tau-independent Binding Site. REGULATION BY POLYGLUTAMYLATION.
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Kinesin and tau bind to distinct sites on microtubules.
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Differential Binding Regulation of Microtubule-associated Proteins MAP1A, MAP1B, and MAP2 by Tubulin Polyglutamylation.
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