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Science 19 December 1986:
Vol. 234. no. 4783, pp. 1573 - 1577
DOI: 10.1126/science.3787263
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Articles

Science, Vol 234, Issue 4783, 1573-1577
Copyright © 1986 by American Association for the Advancement of Science

articles

Lipoprotein mutations in pigs are associated with elevated plasma cholesterol and atherosclerosis

J Rapacz, J Hasler-Rapacz, KM Taylor, WJ Checovich, and AD Attie

A strain of pigs bearing three immunogenetically defined lipoprotein-associated markers (allotypes), designated Lpb5, Lpr1, and Lpu1, has marked hypercholesterolemia on a low fat, cholesterol-free diet. Unlike individuals with familial hypercholesterolemia or WHHL rabbits, the affected pigs have normal low density lipoprotein receptor activity. The animals, by 7 months of age, have extensive atherosclerotic lesions in all three coronary arteries. This strain of pig represents an animal model for atherosclerosis and hypercholesterolemia associated with mutations affecting the structures of plasma lipoproteins. One of the variant apolipoproteins, Lpb5, is apolipoprotein-B. A second variant apolipoprotein (Lpr1), termed apo-R, is a 23-kilodalton protein present in both the very low density (d less than 1.006 g/ml) and the very high density (d greater than 1.21 g/ml) fractions of pig plasma. Isoforms of this protein correlate with two Lpr alleles, Lpr1 and Lpr2. The Lpr genes segregate independently of the Lpb5 and Lpu1 alleles. The Lpu1 allotype is a component of low density lipoprotein and is genetically linked to Lpb5.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunochemical evidence that human apoB differs when expressed in rodent versus human cells.
X. Wang, V. Chauhan, A. T. Nguyen, J. Schultz, J. Davignon, S. G. Young, J. Boren, T. L. Innerarity, H. Rutai, and R. W. Milne (2003)
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Identification of a novel Arg'Cys mutation in the LDL receptor that contributes to spontaneous hypercholesterolemia in pigs.
K. A. A. Grunwald, K. Schueler, P. J. Uelmen, B. A. Lipton, M. Kaiser, K. Buhman, and A. D. Attie (1999)
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Peripheral Vascular Stenosis in Apolipoprotein E-Deficient Mice : Potential Roles of Lipid Deposition, Medial Atrophy, and Adventitial Inflammation.
H. S. Seo, D. M. Lombardi, P. Polinsky, L. Powell-Braxton, S. Bunting, S. M. Schwartz, and M. E. Rosenfeld (1997)
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A comprehensive map of the porcine genome..
G A Rohrer, L J Alexander, Z Hu, T P Smith, J W Keele, and C W Beattie (1996)
Genome Res. 6, 371-391
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Elevated Concentrations of Plasma Lipids and Apolipoproteins B, C-III, and E Are Associated With the Progression of Coronary Artery Disease in Familial Hypercholesterolemic Swine.
J. Hasler-Rapacz, M. F. Prescott, J. Von Linden-Reed, J. M. Rapacz Jr, Z. Hu, and J. Rapacz (1995)
Arterioscler Thromb Vasc Biol 15, 583-592
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