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Science 19 December 1986:
Vol. 234. no. 4783, pp. 1563 - 1566
DOI: 10.1126/science.2431484

Articles

Science, Vol 234, Issue 4783, 1563-1566
Copyright © 1986 by American Association for the Advancement of Science


articles

CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication

CM Walker, DJ Moody, DP Stites, and JA Levy

Lymphocytes bearing the CD8 marker were shown to suppress replication of human immunodeficiency virus (HIV) in peripheral blood mononuclear cells. The effect was dose-dependent and most apparent with autologous lymphocytes; it did not appear to be mediated by a cytotoxic response. This suppression of HIV replication could be demonstrated by the addition of CD8+ cells at the initiation of virus production as well as after several weeks of virus replication by cultured cells. The observations suggest a potential approach to therapy in which autologous CD8 lymphocytes could be administered to individuals to inhibit HIV replication and perhaps progression of disease.


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HIV-specific effector cytotoxic T lymphocytes and HIV-producing cells colocalize in white pulps and germinal centers from infected patients.
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In vitro correlates of HIV-2-mediated HIV-1 protection.
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X. Jin, D. E. Bauer, S. E. Tuttleton, S. Lewin, A. Gettie, J. Blanchard, C. E. Irwin, J. T. Safrit, J. Mittler, L. Weinberger, et al. (1999)
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J. E. Schmitz, M. J. Kuroda, S. Santra, V. G. Sasseville, M. A. Simon, M. A. Lifton, P. Racz, K. Tenner-Racz, M. Dalesandro, B. J. Scallon, et al. (1999)
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Comparative Analysis of Cytotoxic T Lymphocytes in Lymph Nodes and Peripheral Blood of Simian Immunodeficiency Virus-Infected Rhesus Monkeys.
M. J. Kuroda, J. E. Schmitz, W. A. Charini, C. E. Nickerson, C. I. Lord, M. A. Forman, and N. L. Letvin (1999)
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HLA Compatibility Requirements for CD8+-T-Cell-Mediated Suppression of Human Immunodeficiency Virus Replication.
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Vaccine Protection against a Heterologous, Non-Syncytium-Inducing, Primary Human Immunodeficiency Virus.
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J. Virol. 72, 10275-10280
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Natural Killer Cells from HIV-1+ Patients Produce C-C Chemokines and Inhibit HIV-1 Infection.
T. A. Fehniger, G. Herbein, H. Yu, M. I. Para, Z. P. Bernstein, W. A. O'Brien, and M. A. Caligiuri (1998)
J. Immunol. 161, 6433-6438
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Virological and Immunological Features of Long-Term Human Immunodeficiency Virus-Infected Individuals Who Have Remained Asymptomatic Compared With Those Who Have Progressed to Acquired Immunodeficiency Syndrome.
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Blood 92, 3105-3114
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Alloantigen-Stimulated Anti-HIV Activity.
L. A. Pinto, S. Sharpe, D. I. Cohen, and G. M. Shearer (1998)
Blood 92, 3346-3354
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Cytokines, Plasma Immune Activation Markers, and Clinically Relevant Surrogate Markers in Human Immunodeficiency Virus Infection.
J. L. Fahey (1998)
Clin. Vaccine Immunol. 5, 597-603
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HIV-specific T Cell Cytotoxicity Mediated by RANTES Via the Chemokine Receptor CCR3.
F. Hadida, V. Vieillard, B. Autran, I. Clark-Lewis, M. Baggiolini, and P. Debre (1998)
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Inhibition of Simian Immunodeficiency Virus (SIV) Replication by CD8+ T Lymphocytes from Macaques Immunized with Live Attenuated SIV.
M.-C. Gauduin, R. L. Glickman, R. Means, and R. P. Johnson (1998)
J. Virol. 72, 6315-6324
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Recovery of the Immune System With Antiretroviral Therapy: The End of Opportunism?.
W. G. Powderly, A. Landay, and M. M. Lederman (1998)
JAMA 280, 72-77
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   Abstract »    Full Text »    PDF »
Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge.
I. M. Belyakov, M. A. Derby, J. D. Ahlers, B. L. Kelsall, P. Earl, B. Moss, W. Strober, and J. A. Berzofsky (1998)
PNAS 95, 1709-1714
   Abstract »    Full Text »    PDF »
Primary CD8+ cells from HIV-infected individuals can suppress productive infection of macrophages independent of beta -chemokines.
E. Barker, K. N. Bossart, and J. A. Levy (1998)
PNAS 95, 1725-1729
   Abstract »    Full Text »    PDF »
Selection of Virus Variants and Emergence of Virus Escape Mutants after Immunization with an Epitope Vaccine.
L. Mortara, F. Letourneur, H. Gras-masse, A. Venet, J.-G. Guillet, and I. Bourgault-Villada (1998)
J. Virol. 72, 1403-1410
   Abstract »    Full Text »    PDF »
Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia.
J. K. Wong, M. Hezareh, H. F. Günthard, D. V. Havlir, C. C. Ignacio, C. A. Spina, and D. D. Richman (1997)
Science 278, 1291-1295
   Abstract »    Full Text »
HIV versus Cytotoxic T Lymphocytes -- The War Being Lost.
M. B.A. Oldstone (1997)
N. Engl. J. Med. 337, 1306-1308
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Inhibition of HIV-1 Infection by the beta -Chemokine MDC.
R. Pal, A. Garzino-Demo, P. D. Markham, J. Burns, M. Brown, R. C. Gallo, and A. L. DeVico (1997)
Science 278, 695-698
   Abstract »    Full Text »
Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells.
O. O. Yang, A.-C. Tran, S. A. Kalams, R. P. Johnson, M. R. Roberts, and B. D. Walker (1997)
PNAS 94, 11478-11483
   Abstract »    Full Text »    PDF »
Safety of Autologous, Ex Vivo-Expanded Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Infusion in HIV-Infected Patients.
J. Lieberman, P. R. Skolnik, G. R. Parkerson III, J. A. Fabry, B. Landry, J. Bethel, J. Kagan, and the DATRI 006 Study Team (1997)
Blood 90, 2196-2206
   Abstract »    Full Text »    PDF »
Replication-Defective Canarypox (ALVAC) Vectors Effectively Activate Anti-Human Immunodeficiency Virus-1 Cytotoxic T Lymphocytes Present in Infected Patients: Implications for Antigen-Specific Immunotherapy.
G. Ferrari, C. Berend, J. Ottinger, R. Dodge, J. Bartlett, J. Toso, D. Moody, J. Tartaglia, W. I. Cox, E. Paoletti, et al. (1997)
Blood 90, 2406-2416
   Abstract »    Full Text »    PDF »
The CXC chemokine stromal cell-derived factor 1 is not responsible for CD8+ T cell suppression of syncytia-inducing strains of HIV-1.
S. F. Lacey, C. B. McDanal, R. Horuk, and M. L. Greenberg (1997)
PNAS 94, 9842-9847
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Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor.
M. Baier, N. Bannert, A. Werner, K. Lang, and R. Kurth (1997)
PNAS 94, 5273-5277
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C-C Chemokines Released by Lipopolysaccharide (LPS)-stimulated Human Macrophages Suppress HIV-1 Infection in Both Macrophages and T Cells.
A. Verani, G. Scarlatti, M. Comar, E. Tresoldi, S. Polo, M. Giacca, P. Lusso, A. G. Siccardi, and D. Vercelli (1997)
J. Exp. Med. 185, 805-816
   Abstract »    Full Text »    PDF »
Hemophilia and Nonprogressing Human Immunodeficiency Virus Type 1 Infection.
E. Vicenzi, P. Bagnarelli, E. Santagostino, S. Ghezzi, M. Alfano, M. S. Sinnone, G. Fabio, L. Turchetto, G. Moretti, A. Lazzarin, et al. (1997)
Blood 89, 191-200
   Abstract »    Full Text »    PDF »
Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection.
P. Klenerman, R. E. Phillips, C. R. Rinaldo, L. M. Wahl, G. Ogg, R. M. May, A. J. McMichael, and M. A. Nowak (1996)
PNAS 93, 15323-15328
   Abstract »    Full Text »    PDF »
CD8+ T-cell-derived soluble factor(s), but not beta -chemokines RANTES, MIP-1alpha , and MIP-1beta , suppress HIV-1 replication in monocyte/macrophages.
H. Moriuchi, M. Moriuchi, C. Combadiere, P. M. Murphy, and A. S. Fauci (1996)
PNAS 93, 15341-15345
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Sensitivity to inhibition by beta -chemokines correlates with biological phenotypes of primary HIV-1 isolates.
M. Jansson, M. Popovic, A. Karlsson, F. Cocchi, P. Rossi, J. Albert, and H. Wigzell (1996)
PNAS 93, 15382-15387
   Abstract »    Full Text »    PDF »
Lymphocyte-Mediated Cytolysis and Disease.
C.-C. Liu, L. H.Y. Young, and J. D.-E Young (1996)
N. Engl. J. Med. 335, 1651-1659
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Response: Role of beta-Chemokines in Suppressing HIV Replication.
F. Cocchi, A. L. DeVico, A. Garzino-Demo, P. Lusso, and R. C. Gallo (1996)
Science 274, 1394-1395
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Suppression of HIV replication by lymphoid tissue CD8+ cells correlates with the clinical state of HIV-infected individuals.
D. J. Blackbourn, C. E. Mackewicz, E. Barker, T. K. Hunt, B. Herndier, A. T. Haase, and J. A. Levy (1996)
PNAS 93, 13125-13130
   Abstract »    Full Text »    PDF »
Identification of RANTES, MIP-1alpha, and MIP-1beta as the Major HIV-Suppressive Factors Produced by CD8+ T Cells.
F. Cocchi, A. L. DeVico, A. Garzino-Demo, S. K. Arya, R. C. Gallo, and P. Lusso (1995)
Science 270, 1811-1815
   Abstract »    PDF »
Virologic and Immunologic Characterization of Long-Term Survivors of Human Immunodeficiency Virus Type 1 Infection.
Y. Cao, L. Qin, L. Zhang, J. Safrit, and D. D. Ho (1995)
N. Engl. J. Med. 332, 201-208
   Abstract »    Full Text »    PDF »
Infection of a Laboratory Worker with Simian Immunodeficiency Virus.
R. F. Khabbaz, W. Heneine, J. R. George, B. Parekh, T. Rowe, T. Woods, W. M. Switzer, H. M. McClure, M. Murphey-Corb, and T. M. Folks (1994)
N. Engl. J. Med. 330, 172-177
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Vaccines against Human Immunodeficiency Virus -- Progress and Prospects.
N. L. Letvin (1993)
N. Engl. J. Med. 329, 1400-1405
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HIV and AIDS.
J. Laman (1993)
Science 260, 1707-1708
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Risk for Perinatal HIV-1 Transmission According to Maternal Immunologic, Virologic, and Placental Factors.
M. E. St. Louis, M. Kamenga, C. Brown, A. M. Nelson, T. Manzila, V. Batter, F. Behets, U. Kabagabo, R. W. Ryder, M. Oxtoby, et al. (1993)
JAMA 269, 2853-2859
   Abstract »    PDF »



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