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Science 19 December 1986:
Vol. 234. no. 4783, pp. 1519 - 1526
DOI: 10.1126/science.3024320
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Articles
Science, Vol 234, Issue 4783, 1519-1526
Copyright © 1986 by American Association for the Advancement of Science
The metabolism of phosphoinositide-derived messenger molecules
PW Majerus,
TM Connolly,
H Deckmyn,
TS Ross,
TE Bross,
H Ishii,
VS Bansal,
and
DB Wilson
The phosphoinositides are minor phospholipids present in all eukaryotic cells. They are storage forms for messenger molecules that transmit signals across the cell membrane and evoke responses to extracellular agonists. The phosphoinositides break down to liberate messenger molecules or precursors of messenger molecules. Many different compounds are formed, although the functions of only a few are understood. Recent studies elaborating the pathways for formation of products from phosphoinositides and the factors controlling their metabolism are summarized here.
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