Science 12 December 1986: Vol. 234. no. 4782, pp. 1366 - 1371 DOI: 10.1126/science.3024317

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Articles

Isolated Familial Hypogonadotropic Hypogonadism and a GNRH1 Mutation.

J. Bouligand, C. Ghervan, J. A. Tello, S. Brailly-Tabard, S. Salenave, P. Chanson, M. Lombes, R. P. Millar, A. Guiochon-Mantel, and J. Young (2009)
N. Engl. J. Med. 360, 2742-2748
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic mutant D567G but not wild-type human FSH receptor overexpression provides FSH-independent and promiscuous glycoprotein hormone Sertoli cell signaling.

C. M. Allan, P. Lim, M. Robson, J. Spaliviero, and D. J. Handelsman (2009)
Am J Physiol Endocrinol Metab 296, E1022-E1028
 |  Abstract »  |  Full Text »  |  PDF »

Effects of FSH on testicular mRNA transcript levels in the hypogonadal mouse.

M H Abel, D Baban, S Lee, H M Charlton, and P J O'Shaughnessy (2009)
J. Mol. Endocrinol. 42, 291-303
 |  Abstract »  |  Full Text »  |  PDF »

The Histone Deacetylase SIRT1 Controls Male Fertility in Mice Through Regulation of Hypothalamic-Pituitary Gonadotropin Signaling.

U. Kolthur-Seetharam, K. Teerds, D. G. d. Rooij, O. Wendling, M. McBurney, P. Sassone-Corsi, and I. Davidson (2009)
Biol Reprod 80, 384-391
 |  Abstract »  |  Full Text »  |  PDF »

Fine Mapping of "Mini-Muscle," a Recessive Mutation Causing Reduced Hindlimb Muscle Mass in Mice.

J. Hartmann, T. Garland Jr, R. M. Hannon, S. A. Kelly, G. Munoz, and D. Pomp (2008)
J. Hered. 99, 679-687
 |  Abstract »  |  Full Text »  |  PDF »

Loss of the Protein NUPR1 (p8) Leads to Delayed LHB Expression, Delayed Ovarian Maturation, and Testicular Development of a Sertoli-Cell-Only Syndrome-Like Phenotype in Mice.

C. M. Million Passe, C. R. White, M. W. King, P. L. Quirk, J. L. Iovanna, and C. C. Quirk (2008)
Biol Reprod 79, 598-607
 |  Abstract »  |  Full Text »  |  PDF »

Antagonistic Effects of Testosterone and the Endocrine Disruptor Mono-(2-Ethylhexyl) Phthalate on INSL3 Transcription in Leydig Cells.

E. Lague and J. J. Tremblay (2008)
Endocrinology 149, 4688-4694
 |  Abstract »  |  Full Text »  |  PDF »

The Gonadotropin-Releasing Hormone (GnRH) Neuronal Population Is Normal in Size and Distribution in GnRH-Deficient and GnRH Receptor-Mutant Hypogonadal Mice.

J. C. Gill, B. Wadas, P. Chen, W. Portillo, A. Reyna, E. Jorgensen, S. Mani, G. A. Schwarting, S. M. Moenter, S. Tobet, et al. (2008)
Endocrinology 149, 4596-4604
 |  Abstract »  |  Full Text »  |  PDF »

The Mouse Polyubiquitin Gene Ubb Is Essential for Meiotic Progression.

K.-Y. Ryu, S. A. Sinnar, L. G. Reinholdt, S. Vaccari, S. Hall, M. A. Garcia, T. S. Zaitseva, D. M. Bouley, K. Boekelheide, M. A. Handel, et al. (2008)
Mol. Cell. Biol. 28, 1136-1146
 |  Abstract »  |  Full Text »  |  PDF »

Gonadotropin-Releasing Hormone Neuron Requirements for Puberty, Ovulation, and Fertility.

A. E. Herbison, R. Porteous, J.-R. Pape, J. M. Mora, and P. R. Hurst (2008)
Endocrinology 149, 597-604
 |  Abstract »  |  Full Text »  |  PDF »

Hypogonadal Mouse, a Model to Study the Effects of the Endogenous Lack of Gonadotropins on Apoptosis.

O. E Chausiaux, M. H Abel, F. O Baxter, W. T Khaled, P. J.I Ellis, H. M Charlton, and N. A Affara (2008)
Biol Reprod 78, 77-90
 |  Abstract »  |  Full Text »  |  PDF »

Pubertal Impairment in Nhlh2 Null Mice Is Associated with Hypothalamic and Pituitary Deficiencies.

T. Cogliati, P. Delgado-Romero, E. R. Norwitz, J. Guduric-Fuchs, U. B. Kaiser, S. Wray, and I. R. Kirsch (2007)
Mol. Endocrinol. 21, 3013-3027
 |  Abstract »  |  Full Text »  |  PDF »

LH analog and dietary isoflavones support ovarian granulosa cell tumor development in a spontaneous mouse model.

A. M Dorward, K. L Shultz, and W. G Beamer (2007)
Endocr. Relat. Cancer 14, 369-379
 |  Abstract »  |  Full Text »  |  PDF »

Hypogonadal Bone Loss: Sex Steroids or Gonadotropins?.

G. R. Williams (2007)
Endocrinology 148, 2610-2612
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Specificity of the requirement for Foxo3 in primordial follicle activation.

G. B John, L. J Shirley, T. D Gallardo, and D. H Castrillon (2007)
Reproduction 133, 855-863
 |  Abstract »  |  Full Text »  |  PDF »

Developmental expression of the G protein-coupled receptor 54 and three GnRH mRNAs in the teleost fish cobia.

J S. Mohamed, A. D Benninghoff, G J. Holt, and I. A Khan (2007)
J. Mol. Endocrinol. 38, 235-244
 |  Abstract »  |  Full Text »  |  PDF »

Expression and localization of androgen receptor-interacting protein-4 in the testis.

A. Domanskyi, F.-P. Zhang, M. Nurmio, J. J. Palvimo, J. Toppari, and O. A. Janne (2007)
Am J Physiol Endocrinol Metab 292, E513-E522
 |  Abstract »  |  Full Text »  |  PDF »

The Intraovarian Actions of Estrogen Receptor-{alpha} Are Necessary to Repress the Formation of Morphological and Functional Leydig-Like Cells in the Female Gonad.

J. F. Couse, M. M. Yates, K. F. Rodriguez, J. A. Johnson, D. Poirier, and K. S. Korach (2006)
Endocrinology 147, 3666-3678
 |  Abstract »  |  Full Text »  |  PDF »

Maintenance of Spermatogenesis by the Activated Human (Asp567Gly) FSH Receptor During Testicular Regression Due to Hormonal Withdrawal.

C. M. Allan, A. Garcia, J. Spaliviero, M. Jimenez, and D. J. Handelsman (2006)
Biol Reprod 74, 938-944
 |  Abstract »  |  Full Text »  |  PDF »

Somatotropic and Gonadotropic Axes Linkages in Infancy, Childhood, and the Puberty-Adult Transition.

J. D. Veldhuis, J. N. Roemmich, E. J. Richmond, and C. Y. Bowers (2006)
Endocr. Rev. 27, 101-140
 |  Abstract »  |  Full Text »  |  PDF »

Perinatal testosterone surge is required for normal adult bone size but not for normal bone remodeling.

N. A. Sims, K. Brennan, J. Spaliviero, D. J. Handelsman, and M. J. Seibel (2006)
Am J Physiol Endocrinol Metab 290, E456-E462
 |  Abstract »  |  Full Text »  |  PDF »

Deconstructing mammalian reproduction: using knockouts to define fertility pathways.

A. Roy and M. M Matzuk (2006)
Reproduction 131, 207-219
 |  Abstract »  |  Full Text »  |  PDF »

The Orphan Nuclear Receptor NR4A1 Regulates Insulin-Like 3 Gene Transcription in Leydig Cells.

N. M. Robert, L. J. Martin, and J. J. Tremblay (2006)
Biol Reprod 74, 322-330
 |  Abstract »  |  Full Text »  |  PDF »

Reelin provides an inhibitory signal in the migration of gonadotropin-releasing hormone neurons.

A. Cariboni, S. Rakic, A. Liapi, R. Maggi, A. Goffinet, and J. G. Parnavelas (2005)
Development 132, 4709-4718
 |  Abstract »  |  Full Text »  |  PDF »

Gonadotropin Control of Inhibin Secretion and the Relationship to Follicle Type and Number in the hpg Mouse.

Y. Wang, H. Newton, J. A. Spaliviero, C. M. Allan, B. Marshan, D. J. Handelsman, and P. J. Illingworth (2005)
Biol Reprod 73, 610-618
 |  Abstract »  |  Full Text »  |  PDF »

What have we learned about gonadotropin function from gonadotropin subunit and receptor knockout mice?.

T R. Kumar (2005)
Reproduction 130, 293-302
 |  Abstract »  |  Full Text »  |  PDF »

Developmental Regulation of Gonadotropin-releasing Hormone Gene Expression by the MSX and DLX Homeodomain Protein Families.

M. L. Givens, N. Rave-Harel, V. D. Goonewardena, R. Kurotani, S. E. Berdy, C. H. Swan, J. L. R. Rubenstein, B. Robert, and P. L. Mellon (2005)
J. Biol. Chem. 280, 19156-19165
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Mouse Model of Hypogonadotrophic Hypogonadism: N-Ethyl-N-Nitrosourea-Induced Gonadotropin-Releasing Hormone Receptor Gene Mutation.

A. J. Pask, H. Kanasaki, U. B. Kaiser, P. M. Conn, J. A. Janovick, D. W. Stockton, D. L. Hess, M. J. Justice, and R. R. Behringer (2005)
Mol. Endocrinol. 19, 972-981
 |  Abstract »  |  Full Text »  |  PDF »

Follicle-Stimulating Hormone Induced Changes in Gene Expression of Murine Testis.

P. I. Sadate-Ngatchou, D. J. Pouchnik, and M. D. Griswold (2004)
Mol. Endocrinol. 18, 2805-2816
 |  Abstract »  |  Full Text »  |  PDF »

Developmental Expression of Three Forms of Gonadotropin-Releasing Hormone and Ontogeny of the Hypothalamic-Pituitary-Gonadal Axis in Gilthead Seabream (Sparus aurata).

T.-T. Wong, Y. Gothilf, N. Zmora, K. E. Kight, I. Meiri, A. Elizur, and Y. Zohar (2004)
Biol Reprod 71, 1026-1035
 |  Abstract »  |  Full Text »  |  PDF »

Multiple and Overlapping Combinatorial Codes Orchestrate Hormonal Responsiveness and Dictate Cell-Specific Expression of the Genes Encoding Luteinizing Hormone.

J. S. Jorgensen, C. C. Quirk, and J. H. Nilson (2004)
Endocr. Rev. 25, 521-542
 |  Abstract »  |  Full Text »  |  PDF »

Developmental Regulation of Gonadotropin-Releasing Hormone Neurons by Fibroblast Growth Factor Signaling.

J. C. Gill, S. M. Moenter, and P.-S. Tsai (2004)
Endocrinology 145, 3830-3839
 |  Abstract »  |  Full Text »  |  PDF »

Gonadotropin Releasing Hormone-1 Expression in Incisors of Mice.

J. D. R. Tiong, J. G. Pakiam, and S. Wray (2004)
Endocrinology 145, 3608-3612
 |  Abstract »  |  Full Text »  |  PDF »

Influence of mutations affecting gonadotropin production or responsiveness on expression of inhibin subunit mRNA and protein in the mouse ovary.

R. C Hirst, M. H Abel, V. Wilkins, C. Simpson, P. G Knight, F.-P. Zhang, I. Huhtaniemi, T R. Kumar, and H. M Charlton (2004)
Reproduction 128, 43-52
 |  Abstract »  |  Full Text »  |  PDF »

Generation of Thyrotropin-Releasing Hormone Receptor 1-Deficient Mice as an Animal Model of Central Hypothyroidism.

R. Rabeler, J. Mittag, L. Geffers, U. Ruther, M. Leitges, A. F. Parlow, T. J. Visser, and K. Bauer (2004)
Mol. Endocrinol. 18, 1450-1460
 |  Abstract »  |  Full Text »  |  PDF »

Ontogeny of Proteolytic Immunity: IgM SERINE PROTEASES.

S. Planque, Y. Bangale, X.-T. Song, S. Karle, H. Taguchi, B. Poindexter, R. Bick, A. Edmundson, Y. Nishiyama, and S. Paul (2004)
J. Biol. Chem. 279, 14024-14032
 |  Abstract »  |  Full Text »  |  PDF »

Misrouted cell surface GnRH receptors as a disease aetiology for congenital isolated hypogonadotrophic hypogonadism.

A. Ulloa-Aguirre, J. A. Janovick, A. Leanos-Miranda, and P. M. Conn (2004)
Hum. Reprod. Update 10, 177-192
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Testosterone-Regulated Genes in Testes of Hypogonadal Mice Using Oligonucleotide Microarray.

P. I. Sadate-Ngatchou, D. J. Pouchnik, and M. D. Griswold (2004)
Mol. Endocrinol. 18, 422-433
 |  Abstract »  |  Full Text »  |  PDF »

A Novel AP-1 Site Is Critical for Maximal Induction of the Follicle-stimulating Hormone {beta} Gene by Gonadotropin-releasing Hormone.

D. Coss, S. B. R. Jacobs, C. E. Bender, and P. L. Mellon (2004)
J. Biol. Chem. 279, 152-162
 |  Abstract »  |  Full Text »  |  PDF »

Neural transplantation in hypogonadal (hpg) mice - physiology and neurobiology.

H. Charlton (2004)
Reproduction 127, 3-12
 |  Abstract »  |  Full Text »  |  PDF »

Immunomodulatory Actions of Gonadal Steroids May Be Mediated by Gonadotropin-Releasing Hormone.

J. D. Jacobson and M. A. Ansari (2004)
Endocrinology 145, 330-336
 |  Abstract »  |  Full Text »  |  PDF »

Luteinizing Hormone Receptor-Mediated Effects on Initiation of Spermatogenesis in Gonadotropin-Deficient (hpg) Mice Are Replicated by Testosterone.

J. A. Spaliviero, M. Jimenez, C. M. Allan, and D. J. Handelsman (2004)
Biol Reprod 70, 32-38
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Localization of the Gonadotropin-releasing Hormone (GnRH) Receptor to Low Density Membrane Microdomains Is Necessary for GnRH Signaling to ERK.

A. M. Navratil, S. P. Bliss, K. A. Berghorn, J. M. Haughian, T. A. Farmerie, J. K. Graham, C. M. Clay, and M. S. Roberson (2003)
J. Biol. Chem. 278, 31593-31602
 |  Abstract »  |  Full Text »  |  PDF »

Excision of the First Intron from the Gonadotropin-releasing Hormone (GnRH) Transcript Serves as a Key Regulatory Step for GnRH Biosynthesis.

G. H. Son, H. Jung, J. Y. Seong, Y. Choe, D. Geum, and K. Kim (2003)
J. Biol. Chem. 278, 18037-18044
 |  Abstract »  |  Full Text »  |  PDF »

Gonadotrophin-releasing hormone drives melatonin receptor down-regulation in the developing pituitary gland.

J. D. Johnston, S. Messager, F. J. P. Ebling, L. M. Williams, P. Barrett, and D. G. Hazlerigg (2003)
PNAS 100, 2831-2835
 |  Abstract »  |  Full Text »  |  PDF »

Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice.

A. Corradi, L. Croci, V. Broccoli, S. Zecchini, S. Previtali, W. Wurst, S. Amadio, R. Maggi, A. Quattrini, and G. G. Consalez (2003)
Development 130, 401-410
 |  Abstract »  |  Full Text »  |  PDF »

Sertoli and Germ Cell Development in Hypogonadal (hpg) Mice Expressing Transgenic Follicle-Stimulating Hormone Alone or in Combination with Testosterone.

M. Haywood, J. Spaliviero, M. Jimemez, N. J. C. King, D. J. Handelsman, and C. M. Allan (2003)
Endocrinology 144, 509-517
 |  Abstract »  |  Full Text »  |  PDF »

An Activated Human Follicle-Stimulating Hormone (FSH) Receptor Stimulates FSH-Like Activity in Gonadotropin-Deficient Transgenic Mice.

M. Haywood, N. Tymchenko, J. Spaliviero, A. Koch, M. Jimenez, J. Gromoll, M. Simoni, V. Nordhoff, D. J. Handelsman, and C. M. Allan (2002)
Mol. Endocrinol. 16, 2582-2591
 |  Abstract »  |  Full Text »  |  PDF »

The Roles of Circulating High-Density Lipoproteins and Trophic Hormones in the Phenotype of Knockout Mice Lacking the Steroidogenic Acute Regulatory Protein.

T. Ishii, T. Hasegawa, C.-I Pai, N. Yvgi-Ohana, R. Timberg, L. Zhao, G. Majdic, B.-c. Chung, J. Orly, and K. L. Parker (2002)
Mol. Endocrinol. 16, 2297-2309
 |  Abstract »  |  Full Text »  |  PDF »

Protein Origami: Therapeutic Rescue of Misfolded Gene Products.

P. M. Conn, A. Leanos-Miranda, and J. A. Janovick (2002)
Mol. Interv. 2, 308-316
 |  Abstract »  |  Full Text »  |  PDF »

Prostate Epithelial Expression of a Novel Androgen Target Gene.

J. Singh, L. Young, D. J. Handelsman, and Q. Dong (2002)
J Androl 23, 652-660
 |  Abstract »  |  Full Text »  |  PDF »

Minireview: Genetic Models for the Study of Gonadotropin Actions.

K. H. Burns and M. M. Matzuk (2002)
Endocrinology 143, 2823-2835
 |  Abstract »  |  Full Text »  |  PDF »

Rescue of Hypogonadotropic Hypogonadism-Causing and Manufactured GnRH Receptor Mutants by a Specific Protein-Folding Template: Misrouted Proteins as a Novel Disease Etiology and Therapeutic Target.

J. A. Janovick, G. Maya-Nunez, and P. M. Conn (2002)
J. Clin. Endocrinol. Metab. 87, 3255-3262
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Gasz, an Evolutionarily Conserved Gene Expressed Exclusively in Germ Cells and Encoding a Protein with Four Ankyrin Repeats, a Sterile-{alpha} Motif, and a Basic Leucine Zipper.

W. Yan, A. Rajkovic, M. M. Viveiros, K. H. Burns, J. J. Eppig, and M. M. Matzuk (2002)
Mol. Endocrinol. 16, 1168-1184
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Basis of Hypogonadotropic Hypogonadism: Restoration of Mutant (E90K) GnRH Receptor Function by a Deletion at a Distant Site.

G. Maya-Nunez, J. A. Janovick, A. Ulloa-Aguirre, D. Soderlund, P. M. Conn, and J. P. Mendez (2002)
J. Clin. Endocrinol. Metab. 87, 2144-2149
 |  Abstract »  |  Full Text »  |  PDF »

Intact Follicular Maturation and Defective Luteal Function in Mice Deficient for Cyclin- Dependent Kinase-4.

D. S. Moons, S. Jirawatnotai, T. Tsutsui, R. Franks, A. F. Parlow, D. B. Hales, G. Gibori, A. T. Fazleabas, and H. Kiyokawa (2002)
Endocrinology 143, 647-654
 |  Abstract »  |  Full Text »  |  PDF »

First Intron Excision of GnRH Pre-mRNA During Postnatal Development of Normal Mice and Adult Hypogonadal Mice.

J. Y. Seong, B. W. Kim, S. Park, G. H. Son, and K. Kim (2001)
Endocrinology 142, 4454-4461
 |  Abstract »  |  Full Text »  |  PDF »

Perspective: The Importance of Genetic Defects in Humans in Elucidating the Complexities of the Hypothalamic-Pituitary-Gonadal Axis.

S. B. Seminara and W. F. Crowley Jr. (2001)
Endocrinology 142, 2173-2177
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A Novel Transgenic Model to Characterize the Specific Effects of Follicle-Stimulating Hormone on Gonadal Physiology in the Absence of Luteinizing Hormone Actions.

C. M. Allan, M. Haywood, S. Swaraj, J. Spaliviero, A. Koch, M. Jimenez, M. Poutanen, J. Levallet, I. Huhtaniemi, P. Illingworth, et al. (2001)
Endocrinology 142, 2213-2220
 |  Abstract »  |  Full Text »  |  PDF »

A Single Pitx1 Binding Site Is Essential for Activity of the LH{beta} Promoter in Transgenic Mice.

C. C. Quirk, K. L. Lozada, R. A. Keri, and J. H. Nilson (2001)
Mol. Endocrinol. 15, 734-746
 |  Abstract »  |  Full Text »

Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function.

L Zhao, M Bakke, Y Krimkevich, L. Cushman, A. Parlow, S. Camper, and K. Parker (2001)
Development 128, 147-154
 |  Abstract »  |  PDF »

Activation of Translation in Pituitary Gonadotrope Cells by Gonadotropin-Releasing Hormone.

R. Sosnowski, P. L. Mellon, and M. A. Lawson (2000)
Mol. Endocrinol. 14, 1811-1819
 |  Abstract »  |  Full Text »

Soluble Factors Guide Gonadotropin-Releasing Hormone Axonal Targeting to the Median Eminence.

M. J. Gibson, L. Ingraham, and A. Dobrjansky (2000)
Endocrinology 141, 3065-3071
 |  Abstract »  |  Full Text »  |  PDF »

Estrogenic Induction of Spermatogenesis in the Hypogonadal Mouse.

F. J. P. Ebling, A. N. Brooks, A. S. Cronin, H. Ford, and J. B. Kerr (2000)
Endocrinology 141, 2861-2869
 |  Abstract »  |  Full Text »  |  PDF »

An NF-Y Binding Site Is Important for Basal, but Not Gonadotropin-releasing Hormone-stimulated, Expression of the Luteinizing Hormone beta Subunit Gene.

R. A. Keri, D. J. Bachmann, A. Behrooz, B. D. Herr, R. K. Ameduri, C. C. Quirk, and J. H. Nilson (2000)
J. Biol. Chem. 275, 13082-13088
 |  Abstract »  |  Full Text »  |  PDF »

Responsiveness of the Ovine Gonadotropin-Releasing Hormone Receptor Gene to Estradiol and Gonadotropin-Releasing Hormone Is Not Detectable in Vitro But Is Revealed in Transgenic Mice.

D. L. Duval, A. R. Farris, C. C. Quirk, T. M. Nett, D. L. Hamernik, and C. M. Clay (2000)
Endocrinology 141, 1001-1010
 |  Abstract »  |  Full Text »  |  PDF »

Local Regulation of Gonadotroph Function by Pituitary Gonadotropin-Releasing Hormone.

L. Z. Krsmanovic, A. J. Martinez-Fuentes, K. K. Arora, N. Mores, M. Tomic, S. S. Stojilkovic, and K. J. Catt (2000)
Endocrinology 141, 1187-1195
 |  Abstract »  |  Full Text »  |  PDF »

Detection of Estrogen Receptor {alpha} and {beta} Messenger Ribonucleic Acids in Adult Gonadotropin-Releasing Hormone Neurons.

M. J. Skynner, J. A. Sim, and A. E. Herbison (1999)
Endocrinology 140, 5195-5201
 |  Abstract »  |  Full Text »

Spermatogenesis without Gonadotropins: Maintenance Has a Lower Testosterone Threshold than Initiation.

D. J. Handelsman, J. A. Spaliviero, J. M. Simpson, C. M. Allan, and J. Singh (1999)
Endocrinology 140, 3938-3946
 |  Abstract »  |  Full Text »

The Role of Gonadotropin-Releasing Hormone in Murine Preimplantation Embryonic Development.

F. Raga, E. M. Casañ, J. Kruessel, Y. Wen, F. Bonilla-Musoles, and M. L. Polan (1999)
Endocrinology 140, 3705-3712
 |  Abstract »  |  Full Text »

The Oct-2 POU Domain Gene in the Neuroendocrine Brain: A Transcriptional Regulator of Mammalian Puberty.

S. R. Ojeda, J. Hill, D. F. Hill, M. E. Costa, V. Tapia, A. Cornea, and Y. J. Ma (1999)
Endocrinology 140, 3774-3789
 |  Abstract »  |  Full Text »

Imprinting by Neonatal Sex Steroids on the Structure and Function of the Mature Mouse Prostate.

J. Singh and D. J. Handelsman (1999)
Biol Reprod 61, 200-208
 |  Abstract »  |  Full Text »

Egr-1 Is a Downstream Effector of GnRH and Synergizes by Direct Interaction with Ptx1 and SF-1 To Enhance Luteinizing Hormone beta  Gene Transcription.

J. J. Tremblay and J. Drouin (1999)
Mol. Cell. Biol. 19, 2567-2576
 |  Abstract »  |  Full Text »  |  PDF »

Homologous Regulation of the Gonadotropin-Releasing Hormone Receptor Gene Is Partially Mediated by Protein Kinase C Activation of an Activator Protein-1 Element.

B. R. White, D. L. Duval, J. M. Mulvaney, M. S. Roberson, and C. M. Clay (1999)
Mol. Endocrinol. 13, 566-577
 |  Abstract »  |  Full Text »

Thyroid Hormone Is Essential for Pituitary Somatotropes and Lactotropes.

J. H. Stahl, S. K. Kendall, M. L. Brinkmeier, T. L. Greco, D. E. Watkins-Chow, A. Campos-Barros, R. V. Lloyd, and S. A. Camper (1999)
Endocrinology 140, 1884-1892
 |  Abstract »  |  Full Text »

GABA- and Glutamate-Activated Channels in Green Fluorescent Protein-Tagged Gonadotropin-Releasing Hormone Neurons in Transgenic Mice.

D. J. Spergel, U. Kruth, D. F. Hanley, R. Sprengel, and P. H. Seeburg (1999)
J. Neurosci. 19, 2037-2050
 |  Abstract »  |  Full Text »  |  PDF »

Resistance of Hypogonadic Patients with Mutated GnRH Receptor Genes to Pulsatile GnRH Administration.

P. Caron, S. Chauvin, S. Christin-Maitre, A. Bennet, N. Lahlou, R. Counis, P. Bouchard, and M.-L. Kottler (1999)
J. Clin. Endocrinol. Metab. 84, 990-996
 |  Abstract »  |  Full Text »

Embryonic Development of the Gonadotropin-Releasing Hormone (GnRH) System in the Chick: A Spatio-Temporal Analysis of GnRH Neuronal Generation, Site of Origin, and Migration.

E. M. Mulrenin, J. W. Witkin, and A.-J. Silverman (1999)
Endocrinology 140, 422-433
 |  Abstract »  |  Full Text »

Gonadotropin-Releasing Hormone Deficiency in the Human (Idiopathic Hypogonadotropic Hypogonadism and Kallmann's Syndrome): Pathophysiological and Genetic Considerations.

S. B. Seminara, F. J. Hayes, and W. F. Crowley Jr. (1998)
Endocr. Rev. 19, 521-539
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Hormone-Induced Proliferation and Differentiation of Granulosa Cells: A Coordinated Balance of the Cell Cycle Regulators Cyclin D2 and p27Kip1.

R. L. Robker and J. S. Richards (1998)
Mol. Endocrinol. 12, 924-940
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The Role of Estrogen Receptors and Androgen Receptors in Sex Steroid Regulation of B Lymphopoiesis.

G. Smithson, J. F. Couse, D. B. Lubahn, K. S. Korach, and P. W. Kincade (1998)
J. Immunol. 161, 27-34
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Hormonal Control of the Cell Cycle in Ovarian Cells: Proliferation Versus Differentiation.

R. L. Robker and J. S. Richards (1998)
Biol Reprod 59, 476-482
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Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH.

D Acampora, S Mazan, F Tuorto, V Avantaggiato, J. Tremblay, D Lazzaro, A di Carlo, A Mariano, P. Macchia, G Corte, et al. (1998)
Development 125, 1229-1239
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Overexpression of Mouse Follistatin Causes Reproductive Defects in Transgenic Mice.

Q. Guo, T. R. Kumar, T. Woodruff, L. A. Hadsell, F. J. DeMayo, and M. M. Matzuk (1998)
Mol. Endocrinol. 12, 96-106
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Exaggerated Free {alpha}-Subunit Levels during Pulsatile Gonadotropin-Releasing Hormone Replacement in Women with Idiopathic Hypogonadotropic Hypogonadism.

H. B. Lavoie, K. A. Martin, A. E. Taylor, W. F. Crowley, and J. E. Hall (1998)
J. Clin. Endocrinol. Metab. 83, 241-247
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A Family with Hypogonadotropic Hypogonadism and Mutations in the Gonadotropin-Releasing Hormone Receptor.

N. de Roux, J. Young, M. Misrahi, R. Genet, P. Chanson, G. Schaison, and E. Milgrom (1997)
N. Engl. J. Med. 337, 1597-1603
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Characterization of Germ Cell-Specific Expression of the Orphan Nuclear Receptor, Germ Cell Nuclear Factor.

D. Katz, C. Niederberger, G. R. Slaughter, and A. J. Cooney (1997)
Endocrinology 138, 4364-4372
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Gonadotropin-Releasing Hormone Axons Target the Median Eminence: In Vitro Evidence for Diffusible Chemoattractive Signals from the Mediobasal Hypothalamus.

M.-C. Rogers, A.-J. Silverman, and M. J. Gibson (1997)
Endocrinology 138, 3956-3966
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Gonadal Peptides as Mediators of Development and Functional Control of the Testis: An Integrated System with Hormones and Local Environment.

L. Gnessi, A. Fabbri, and G. Spera (1997)
Endocr. Rev. 18, 541-609
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Characterization of Multiple Promoters Directing Tissue-Specific Expression of the Human Gonadotropin-Releasing Hormone Gene.

K.-W. Dong, K.-L. Yu, Z.-G. Chen, Y.-D. Chen, and J. L. Roberts (1997)
Endocrinology 138, 2754-2762
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Gonadotropin-Releasing Hormone and Gonadotropin-Releasing Hormone Receptor Messenger Ribonucleic Acids Expression in Nontumorous and Neoplastic Pituitaries.

N. Sanno, L. Jin, X. Qian, R. Y. Osamura, B. W. Scheithauer, K. Kovacs, and R. V. Lloyd (1997)
J. Clin. Endocrinol. Metab. 82, 1974-1982
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Cell-specific Expression of the Human Gonadotropin-releasing Hormone Gene in Transgenic Animals.

A. M. Wolfe, S. Wray, H. Westphal, and S. Radovick (1996)
J. Biol. Chem. 271, 20018-20023
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The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis..

H A Ingraham, D S Lala, Y Ikeda, X Luo, W H Shen, M W Nachtigal, R Abbud, J H Nilson, and K L Parker (1994)
Genes & Dev. 8, 2302-2312
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The hypogonadal mouse: reproductive functions restored by gene therapy.

A. Mason, S. Pitts, K Nikolics, E Szonyi, J. Wilcox, P. Seeburg, and T. Stewart (1986)
Science 234, 1372-1378
 |  Abstract »  |  PDF »

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