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Science 12 December 1986:
Vol. 234. no. 4782, pp. 1349 - 1356
DOI: 10.1126/science.2431481
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Articles

Science, Vol 234, Issue 4782, 1349-1356
Copyright © 1986 by American Association for the Advancement of Science

articles

Research toward malaria vaccines

LH Miller, RJ Howard, R Carter, MF Good, V Nussenzweig, and RS Nussenzweig

Malaria exacts a toll of disease to people in the Tropics that seems incomprehensible to those only familiar with medicine and human health in the developed world. The methods of molecular biology, immunology, and cell biology are now being used to develop an antimalarial vaccine. The Plasmodium parasites that cause malaria have many stages in their life cycle. Each stage is antigenically distinct and potentially could be interrupted by different vaccines. However, achieving complete protection by vaccination may require a better understanding of the complexities of B- and T-cell priming in natural infections and the development of an appropriate adjuvant for use in humans.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mosquito Heparan Sulfate and Its Potential Role in Malaria Infection and Transmission.
P. Sinnis, A. Coppi, T. Toida, H. Toyoda, A. Kinoshita-Toyoda, J. Xie, M. M. Kemp, and R. J. Linhardt (2007)
J. Biol. Chem. 282, 25376-25384
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The challenge of malaria.
L. Miller (1992)
Science 257, 36-37
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Induction of Plasmodium falciparum transmission-blocking antibodies by recombinant vaccinia virus.
D. Kaslow, S. Isaacs, I. Quakyi, R. Gwadz, B Moss, and D. Keister (1991)
Science 252, 1310-1313
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Prevention of Malaria.
S. L. Hoffman (1991)
JAMA 265, 398-399
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Parasitic protozoa and helminths: biological and immunological challenges.
A. Mahmoud (1989)
Science 246, 1015-1022
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Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.
D. Krogstad, I. Gluzman, D. Kyle, A. Oduola, S. Martin, W. Milhous, and P. Schlesinger (1987)
Science 238, 1283-1285
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