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Science 5 December 1986:
Vol. 234. no. 4781, pp. 1254 - 1256
DOI: 10.1126/science.3775384
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Articles

Science, Vol 234, Issue 4781, 1254-1256
Copyright © 1986 by American Association for the Advancement of Science

articles

Lactate transporter defect: a new disease of muscle

WN Fishbein

New methods were used to identify the abnormality in a patient who showed evidence of neuromuscular dysfunction on extensive clinical examination. The methods revealed that the lactate content of the patient's skeletal muscle does not decline normally after exercise and that his red cells are defective in lactate transport. These results suggest that skeletal muscle and erythrocyte membranes share the same genetic lactate transporter (or a common subunit), which is deficient in this patient. This defect may be a common cause of elevated serum creatine kinase levels, as seen in the patient described here and of unexplained episodes of rhabdomyolysis and myoglobinuria.


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