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Science 21 November 1986:
Vol. 234. no. 4779, pp. 964 - 969
DOI: 10.1126/science.3535069
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Articles

Science, Vol 234, Issue 4779, 964-969
Copyright © 1986 by American Association for the Advancement of Science

articles

Drug-resistant Salmonella in the United States: an epidemiologic perspective

ML Cohen and RV Tauxe

Salmonellosis poses a health problem of large proportions in the United States. Annually, it accounts for more than 40,000 reported cases, 500 deaths, and financial costs well in excess of $50 million. Antimicrobial resistance is increasing in Salmonella strains, a finding that has important public health implications. Although the chain of transmission of the bacteria is often complex, combined epidemiologic and laboratory studies with the use of new methods in molecular biology make it possible to trace antimicrobial-resistant salmonellae to their primary source--foods of animal origin. These studies suggest that the antimicrobial drugs to which food animals are exposed provide selective pressure that leads to the appearance and persistence of resistant strains.


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The Emergence in Taiwan of Fluoroquinolone Resistance in Salmonella enterica Serotype Choleraesuis.
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Ceftriaxone-Resistant Salmonella Infection Acquired by a Child from Cattle.
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Extraintestinal Salmonellosis in a General Hospital (1991 to 1996): Relationships between Salmonella Genomic Groups and Clinical Presentations.
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Molecular diagnostics of infectious diseases.
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Preventing the Emergence of Antimicrobial Resistance: A Call for Action by Clinicians, Public Health Officials, and Patients.
B. Schwartz, D. M. Bell, and J. M. Hughes (1997)
JAMA 278, 944-945
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Epidemiology of Drug Resistance: Implications for a Post--Antimicrobial Era.
M. L. Cohen (1992)
Science 257, 1050-1055
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Failure of Ciprofloxacin to Eradicate Convalescent Fecal Excretion after Acute Salmonellosis: Experience during an Outbreak in Health Care Workers.
M. A. Neill, S. M. Opal, J. Heelan, R. Giusti, J. E. Cassidy, R. White, and K. H. Mayer (1991)
Ann Intern Med 114, 195-199
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In Vivo Fate of End-Chain Radiolabelled Poly({beta}-malic acid), a Water-Soluble Biodegradable Drug Carrier.
P. Fournie, D. Domurado, P. Guerin, C. Braud, M. Vert, and J.-C. Madelmont (1990)
Journal of Bioactive and Compatible Polymers 5, 381-395
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Epithelial cell surfaces induce Salmonella proteins required for bacterial adherence and invasion.
B. Finlay, F Heffron, and S Falkow (1989)
Science 243, 940-943
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Changes in Antimicrobial Resistance of Salmonella Isolated From Humans in the United States.
K. L. MacDonald, M. L. Cohen, N. T. Hargrett-Bean, J. G. Wells, N. D. Puhr, S. F. Collin, and P. A. Blake (1987)
JAMA 258, 1496-1499
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