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Science 21 November 1986:
Vol. 234. no. 4779, pp. 964 - 969
DOI: 10.1126/science.3535069
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Articles

Science, Vol 234, Issue 4779, 964-969
Copyright © 1986 by American Association for the Advancement of Science

articles

Drug-resistant Salmonella in the United States: an epidemiologic perspective

ML Cohen and RV Tauxe

Salmonellosis poses a health problem of large proportions in the United States. Annually, it accounts for more than 40,000 reported cases, 500 deaths, and financial costs well in excess of $50 million. Antimicrobial resistance is increasing in Salmonella strains, a finding that has important public health implications. Although the chain of transmission of the bacteria is often complex, combined epidemiologic and laboratory studies with the use of new methods in molecular biology make it possible to trace antimicrobial-resistant salmonellae to their primary source--foods of animal origin. These studies suggest that the antimicrobial drugs to which food animals are exposed provide selective pressure that leads to the appearance and persistence of resistant strains.


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Epidemiology of Drug Resistance: Implications for a Post--Antimicrobial Era.
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Failure of Ciprofloxacin to Eradicate Convalescent Fecal Excretion after Acute Salmonellosis: Experience during an Outbreak in Health Care Workers.
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Ann Intern Med 114, 195-199
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