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Science 7 November 1986:
Vol. 234. no. 4777, pp. 748 - 751
DOI: 10.1126/science.3490690
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Articles

Science, Vol 234, Issue 4777, 748-751
Copyright © 1986 by American Association for the Advancement of Science

articles

Intracellular accumulation of T-cell receptor complex molecules in a human T-cell line

DB Tse, M Al-Haideri, B Pernis, CR Cantor, and CY Wang

This work was aimed at understanding the mechanisms of T-lymphocyte function by studying the cellular distribution and traffic of molecules of the T-cell receptor complex. The accumulation of specific molecules in intracytoplasmic vesicles is related to the activation of T lymphocytes. Some of these molecules include acid hydrolases, the transferrin receptor, and class I antigens of the major histocompatibility complex. Molecules of the T-cell receptor complex have now also been found in intracytoplasmic vesicles in a human T-cell line derived from a lymphoblastic leukemia. Such vesicles were tightly associated with the cytoplasmic microtubule network. One functional aspect of this association is a cellular pathway by which vesicles traveling to and from the cell surface converge in an area of the cells that is rich in processing enzymes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
T Cell Receptor Engagement Leads to Phosphorylation of Clathrin Heavy Chain during Receptor Internalization.
V. L. Crotzer, A. S. Mabardy, A. Weiss, and F. M. Brodsky (2004)
J. Exp. Med. 199, 981-991
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Science. ISSN 0036-8075 (print), 1095-9203 (online)