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Science 7 November 1986:
Vol. 234. no. 4777, pp. 743 - 746
DOI: 10.1126/science.3095921
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Articles

Science, Vol 234, Issue 4777, 743-746
Copyright © 1986 by American Association for the Advancement of Science

articles

Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide

JP Jakway and AL DeFranco

Lipopolysaccharide, a component of the outer membrane of Gram-negative bacteria, activates B lymphocytes and macrophages. Pertussis toxin, which inactivates several members of the G protein family of signaling components, including Gi and transducin, was found to inhibit the lipopolysaccharide-induced responses of the WEHI-231 B lymphoma cell line and the P388D1 macrophage cell line. These results, combined with the demonstration that lipopolysaccharide inhibits adenylate cyclase activity in P388D1 cells, strongly argues that lipopolysaccharide activation of cells is mediated by a Gi-like receptor-effector coupling protein.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pertussis Toxin Inhibits Early Chemokine Production To Delay Neutrophil Recruitment in Response to Bordetella pertussis Respiratory Tract Infection in Mice.
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Infect. Immun. 76, 5139-5148
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G-protein-coupled receptor expression, function, and signaling in macrophages.
J. Lattin, D. A. Zidar, K. Schroder, S. Kellie, D. A. Hume, and M. J. Sweet (2007)
J. Leukoc. Biol. 82, 16-32
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Pertussis Toxin Targets Airway Macrophages To Promote Bordetella pertussis Infection of the Respiratory Tract.
N. H. Carbonetti, G. V. Artamonova, N. Van Rooijen, and V. I. Ayala (2007)
Infect. Immun. 75, 1713-1720
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Mastoparan, a G Protein Agonist Peptide, Differentially Modulates TLR4- and TLR2-Mediated Signaling in Human Endothelial Cells and Murine Macrophages.
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J. Immunol. 174, 4252-4261
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Activation of Acid Sphingomyelinase and Its Inhibition by the Nitric Oxide/Cyclic Guanosine 3',5'-Monophosphate Pathway: Key Events in Escherichia coli-Elicited Apoptosis of Dendritic Cells.
S. Falcone, C. Perrotta, C. De Palma, A. Pisconti, C. Sciorati, A. Capobianco, P. Rovere-Querini, A. A. Manfredi, and E. Clementi (2004)
J. Immunol. 173, 4452-4463
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Suppression of Serum Antibody Responses by Pertussis Toxin after Respiratory Tract Colonization by Bordetella pertussis and Identification of an Immunodominant Lipoprotein.
N. H. Carbonetti, G. V. Artamonova, C. Andreasen, E. Dudley, R. M. Mays, and Z. E. V. Worthington (2004)
Infect. Immun. 72, 3350-3358
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Lipopolysaccharide binds to and activates A1 adenosine receptors on human pulmonary artery endothelial cells.
C. Neely Wilson and V. K. Batra (2002)
Innate Immunity 8, 263-271
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Invited review: Bacterial lipopolysaccharides and innate immunity.
C. Alexander and E. Th. Rietschel (2001)
Innate Immunity 7, 167-202
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Lipopolysaccharide Inhibits Virus-mediated Induction of Interferon Genes by Disruption of Nuclear Transport of Interferon Regulatory Factors 3 and 7.
Y.-T. Juang, W.-C. Au, W. Lowther, J. Hiscott, and P. M. Pitha (1999)
J. Biol. Chem. 274, 18060-18066
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Involvement of C-Abl Tyrosine Kinase in Lipopolysaccharide- Induced Macrophage Activation.
Q. Le, R. Daniel, S.-W. Chung, A. D. Kang, T. K. Eisenstein, B. M. Sultzer, H. Simpkins, and P. M. C. Wong (1998)
J. Immunol. 160, 3330-3336
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Endotoxin-induced desensitization of THP-1 cells is not associated with altered G protein binding or content.
M. Durando, S.H. Ashton, M.A. Makhlouf, R. Simmons-Wagner, P.V. Halushka, and J.A. Cook (1997)
Innate Immunity 4, 97-103
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Physicochemical and biological characterizations of complex formation between lipopolysaccharide and lysozyme.
K. Takada, N. Ohno, and T. Yadomae (1995)
Innate Immunity 2, 255-262
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Cross-tolerance between bacterial endotoxin and group B Streptococcus in neonatal rats.
G. Mancuso, G. Blandino, V. Cusumano, R. Alba Merendino, P. Rocca, G. Teti, and J.A. Cook (1994)
Innate Immunity 1, 114-119
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