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Science 31 October 1986:
Vol. 234. no. 4776, pp. 574 - 581
DOI: 10.1126/science.3020690
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Articles

Science, Vol 234, Issue 4776, 574-581
Copyright © 1986 by American Association for the Advancement of Science

articles

Neuroleukin: a lymphokine product of lectin-stimulated T cells

ME Gurney, BR Apatoff, GT Spear, MJ Baumel, JP Antel, MB Bania, and AT Reder

Neuroleukin is a lymphokine product of lectin-stimulated T cells that induces immunoglobulin secretion by cultured human peripheral blood mononuclear cells. Neuroleukin acts early in the in vitro response that leads to formation of antibody-secreting cells, but continued production of immunoglobulin by differentiated antibody-secreting cells is neuroleukin-independent. Although the factor is not directly mitogenic, cellular proliferation is a late component of the response to neuroleukin. Neuroleukin does not have B-cell growth factor (BCGF) or B-cell differentiation factor (BCDF) activity in defined assays. Neuroleukin-evoked induction of immunoglobulin secretion is both monocyte- and T-cell-dependent.


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