Science 24 October 1986: Vol. 234. no. 4775, pp. 470 - 474 DOI: 10.1126/science.3764421

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Articles

Crucial Role of TNF Receptors 1 and 2 in the Control of Polymicrobial Sepsis.

T. Secher, V. Vasseur, D. M. Poisson, J. A. Mitchell, F. Q. Cunha, J. C. Alves-Filho, and B. Ryffel (2009)
J. Immunol. 182, 7855-7864
 |  Abstract »  |  Full Text »  |  PDF »

IL-17 produced by Paneth cells drives TNF-induced shock.

N. Takahashi, I. Vanlaere, R. de Rycke, A. Cauwels, L. A.B Joosten, E. Lubberts, W. B. van den Berg, and C. Libert (2008)
J. Exp. Med. 205, 1755-1761
 |  Abstract »  |  Full Text »  |  PDF »

First Demonstration of the Role of TNF in the Pathogenesis of Disease.

J. Vilcek (2008)
J. Immunol. 181, 5-6
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Ghrelin Protects against Experimental Sepsis by Inhibiting High-Mobility Group Box 1 Release and by Killing Bacteria.

A. Chorny, P. Anderson, E. Gonzalez-Rey, and M. Delgado (2008)
J. Immunol. 180, 8369-8377
 |  Abstract »  |  Full Text »  |  PDF »

LPS-induced up-regulation of TGF-{beta} receptor 1 is associated with TNF-{alpha} expression in human monocyte-derived macrophages.

Y. Chen, C. S. K. Kam, F. Q. Liu, Y. Liu, V. C. H. Lui, J. R. Lamb, and P. K. H. Tam (2008)
J. Leukoc. Biol. 83, 1165-1173
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase D1 Plays a Key Role in TNF-{alpha} Signaling.

S. Sethu, G. Mendez-Corao, and A. J. Melendez (2008)
J. Immunol. 180, 6027-6034
 |  Abstract »  |  Full Text »  |  PDF »

Neuropeptides Rescue Mice from Lethal Sepsis by Down-regulating Secretion of the Late-Acting Inflammatory Mediator High Mobility Group Box 1.

A. Chorny and M. Delgado (2008)
Am. J. Pathol. 172, 1297-1307
 |  Abstract »  |  Full Text »  |  PDF »

ATF3 Protects against Renal Ischemia-Reperfusion Injury.

T. Yoshida, H. Sugiura, M. Mitobe, K. Tsuchiya, S. Shirota, S. Nishimura, S. Shiohira, H. Ito, K. Nobori, S. R. Gullans, et al. (2008)
J. Am. Soc. Nephrol. 19, 217-224
 |  Abstract »  |  Full Text »  |  PDF »

Neoadjuvant Treatment of Locally Advanced Soft Tissue Sarcoma of the Limbs: Which Treatment to Choose?.

P. Hohenberger and W. M. Wysocki (2008)
Oncologist 13, 175-186
 |  Abstract »  |  Full Text »  |  PDF »

Role of CD14 in Responses to Clinical Isolates of Escherichia coli: Effects of K1 Capsule Expression.

S. Metkar, S. Awasthi, E. Denamur, K. S. Kim, S. C. Gangloff, S. Teichberg, A. Haziot, J. Silver, and S. M. Goyert (2007)
Infect. Immun. 75, 5415-5424
 |  Abstract »  |  Full Text »  |  PDF »

Protection of Zinc against Tumor Necrosis Factor Induced Lethal Inflammation Depends on Heat Shock Protein 70 and Allows Safe Antitumor Therapy.

W. Van Molle, M. Van Roy, T. Van Bogaert, L. Dejager, P. Van Lint, I. Vanlaere, K. Sekikawa, G. Kollias, and C. Libert (2007)
Cancer Res. 67, 7301-7307
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: TNF-{alpha} suppresses the expression of clock genes by interfering with E-box-mediated transcription.

G. Cavadini, S. Petrzilka, P. Kohler, C. Jud, I. Tobler, T. Birchler, and A. Fontana (2007)
PNAS 104, 12843-12848
 |  Abstract »  |  Full Text »  |  PDF »

Pathophysiology of Sepsis.

D. G. Remick (2007)
Am. J. Pathol. 170, 1435-1444
 |  Abstract »  |  Full Text »  |  PDF »

TNF-{alpha} neutralization ameliorates obstruction-induced renal fibrosis and dysfunction.

K. K. Meldrum, R. Misseri, P. Metcalfe, C. A. Dinarello, K. L. Hile, and D. R. Meldrum (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R1456-R1464
 |  Abstract »  |  Full Text »  |  PDF »

Micronutrients in HIV-positive persons receiving highly active antiretroviral therapy.

P. K Drain, R. Kupka, F. Mugusi, and W. W Fawzi (2007)
Am. J. Clinical Nutrition 85, 333-345
 |  Abstract »  |  Full Text »  |  PDF »

The disconnect between animal models of sepsis and human sepsis.

D. Rittirsch, L. M. Hoesel, and P. A. Ward (2007)
J. Leukoc. Biol. 81, 137-143
 |  Abstract »  |  Full Text »  |  PDF »

Gene knockout of the KCNJ8-encoded Kir6.1 KATP channel imparts fatal susceptibility to endotoxemia.

G. C. Kane, C.-F. Lam, F. O'Cochlain, D. M. Hodgson, S. Reyes, X.-K. Liu, T. Miki, S. Seino, Z. S. Katusic, and A. Terzic (2006)
FASEB J 20, 2271-2280
 |  Abstract »  |  Full Text »  |  PDF »

p38 Mitogen-Activated Protein Kinase: A Future Target for Heart Failure Therapy?.

R. Kerkela and T. Force (2006)
J. Am. Coll. Cardiol. 48, 556-558
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Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse.

M. K. Mohammad, M. Morran, B. Slotterbeck, D. W. Leaman, Y. Sun, H. v. Grafenstein, S.-C. Hong, and M. F. McInerney (2006)
Int. Immunol. 18, 1101-1113
 |  Abstract »  |  Full Text »  |  PDF »

Urocortin and Adrenomedullin Prevent Lethal Endotoxemia by Down-Regulating the Inflammatory Response.

E. Gonzalez-Rey, A. Chorny, N. Varela, G. Robledo, and M. Delgado (2006)
Am. J. Pathol. 168, 1921-1930
 |  Abstract »  |  Full Text »  |  PDF »

Time course of cytokine, corticosterone, and tissue injury responses in mice during heat strain recovery.

L. R. Leon, M. D. Blaha, and D. A. DuBose (2006)
J Appl Physiol 100, 1400-1409
 |  Abstract »  |  Full Text »  |  PDF »

Cortistatin, a new antiinflammatory peptide with therapeutic effect on lethal endotoxemia.

E. Gonzalez-Rey, A. Chorny, G. Robledo, and M. Delgado (2006)
J. Exp. Med. 203, 563-571
 |  Abstract »  |  Full Text »  |  PDF »

Lipoteichoic Acid-Induced Nitric Oxide Production Depends on the Activation of Platelet-Activating Factor Receptor and Jak2.

S. H. Han, J. H. Kim, H. S. Seo, M. H. Martin, G.-H. Chung, S. M. Michalek, and M. H. Nahm (2006)
J. Immunol. 176, 573-579
 |  Abstract »  |  Full Text »  |  PDF »

Resistance of Collagenase-2 (Matrix Metalloproteinase-8)-Deficient Mice to TNF-Induced Lethal Hepatitis.

P. Van Lint, B. Wielockx, L. Puimege, A. Noel, C. Lopez-Otin, and C. Libert (2005)
J. Immunol. 175, 7642-7649
 |  Abstract »  |  Full Text »  |  PDF »

Defining the Interaction of the Treponema pallidum Adhesin Tp0751 with Laminin.

C. E. Cameron, N. L. Brouwer, L. M. Tisch, and J. M. Y. Kuroiwa (2005)
Infect. Immun. 73, 7485-7494
 |  Abstract »  |  Full Text »  |  PDF »

Fat meets the cholinergic antiinflammatory pathway.

K. J. Tracey (2005)
J. Exp. Med. 202, 1017-1021
 |  Abstract »  |  Full Text »  |  PDF »

Sevoflurane Pretreatment Inhibits Endotoxin-Induced Shock in Rats.

Y. Kidani, T. Taniguchi, H. Kanakura, Y. Takemoto, K. Tsuda, and K. Yamamoto (2005)
Anesth. Analg. 101, 1152-1156
 |  Abstract »  |  Full Text »  |  PDF »

In vivo evaluation of ocular inflammatory responses in experimental diabetes.

H Tamura, J Kiryu, K Miyamoto, K Nishijima, H Katsuta, S Miyahara, F Hirose, Y Honda, and N Yoshimura (2005)
Br. J. Ophthalmol. 89, 1052-1057
 |  Abstract »  |  Full Text »  |  PDF »

Heparin Binds to Lipopolysaccharide (LPS)-Binding Protein, Facilitates the Transfer of LPS to CD14, and Enhances LPS-Induced Activation of Peripheral Blood Monocytes.

M. Heinzelmann and H. Bosshart (2005)
J. Immunol. 174, 2280-2287
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine-Induced Modulation of Cardiac Function.

S. D. Prabhu (2004)
Circ. Res. 95, 1140-1153
 |  Abstract »  |  Full Text »  |  PDF »

Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms.

G. Chen, J. Li, M. Ochani, B. Rendon-Mitchell, X. Qiang, S. Susarla, L. Ulloa, H. Yang, S. Fan, S. M. Goyert, et al. (2004)
J. Leukoc. Biol. 76, 994-1001
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Attenuates the Systemic Inflammatory Response in Endotoxemic Rats.

M. G. Jeschke, D. Klein, U. Bolder, and R. Einspanier (2004)
Endocrinology 145, 4084-4093
 |  Abstract »  |  Full Text »  |  PDF »

Pathogenesis of Malaria and Clinically Similar Conditions.

I. A. Clark, L. M. Alleva, A. C. Mills, and W. B. Cowden (2004)
Clin. Microbiol. Rev. 17, 509-539
 |  Abstract »  |  Full Text »  |  PDF »

Bacterial endotoxin modifies heat shock factor-1 activity in RAW 264.7 cells: implications for TNF-{alpha} regulation during exposure to febrile range temperatures.

I. S. Singh, J.-R. He, L. Hester, M. J. Fenton, and J. D. Hasday (2004)
Innate Immunity 10, 175-184
 |  Abstract »  |  PDF »

Role for Moesin in Lipopolysaccharide-Stimulated Signal Transduction.

I. Iontcheva, S. Amar, K. H. Zawawi, A. Kantarci, and T. E. Van Dyke (2004)
Infect. Immun. 72, 2312-2320
 |  Abstract »  |  Full Text »  |  PDF »

Distinct pathways of LPS-induced NF-{kappa}B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.

E. Andreakos, S. M. Sacre, C. Smith, A. Lundberg, S. Kiriakidis, T. Stonehouse, C. Monaco, M. Feldmann, and B. M. Foxwell (2004)
Blood 103, 2229-2237
 |  Abstract »  |  Full Text »  |  PDF »

Fc{gamma}RIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis.

M. R. Clatworthy and K. G.C. Smith (2004)
J. Exp. Med. 199, 717-723
 |  Abstract »  |  Full Text »  |  PDF »

Molecular cloning and characterization of mouse LITAF cDNA: role in the regulation of tumor necrosis factor-{alpha} (TNF-{alpha}) gene expression.

A.-L. Bolcato-Bellemin, M.-G. Mattei, M. Fenton, and S. Amar (2004)
Innate Immunity 10, 15-23
 |  Abstract »  |  PDF »

Reversing established sepsis with antagonists of endogenous high-mobility group box 1.

H. Yang, M. Ochani, J. Li, X. Qiang, M. Tanovic, H. E. Harris, S. M. Susarla, L. Ulloa, H. Wang, R. DiRaimo, et al. (2004)
PNAS 101, 296-301
 |  Abstract »  |  Full Text »  |  PDF »

Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2.

B. Lainez, J. M. Fernandez-Real, X. Romero, E. Esplugues, J. D. Canete, W. Ricart, and P. Engel (2004)
Int. Immunol. 16, 169-177
 |  Abstract »  |  Full Text »  |  PDF »

Neural inhibition of inflammation: the cholinergic anti-inflammatory pathway.

C. J. Czura, S. G. Friedman, and K. J. Tracey (2003)
Innate Immunity 9, 409-413
 |  Abstract »  |  PDF »

Effect of tumor necrosis Factor-Alphaon endothelial and inducible nitric oxidesynthase messenger ribonucleic acidexpression and nitric oxide synthesisin ischemic and nonischemic isolated rat heart.

Y. Paz, I. Frolkis, D. Pevni, I. Shapira, Y. Yuhas, A. Iaina, Y. Wollman, T. Chernichovski, N. Nesher, C. Locker, et al. (2003)
J. Am. Coll. Cardiol. 42, 1299-1305
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Hypothermia on Mortality and Inflammatory Responses to Endotoxin-Induced Shock in Rats.

T. Taniguchi, H. Kanakura, Y. Takemoto, and K. Yamamoto (2003)
Clin. Vaccine Immunol. 10, 940-943
 |  Abstract »  |  Full Text »  |  PDF »

Endothelial Cells Are Main Producers of Interleukin 8 through Toll-Like Receptor 2 and 4 Signaling during Bacterial Infection in Leukopenic Cancer Patients.

C. S. M. Oude Nijhuis, E. Vellenga, S. M. G. J. Daenen, W. A. Kamps, and E. S. J. M. de Bont (2003)
Clin. Vaccine Immunol. 10, 558-563
 |  Abstract »  |  Full Text »  |  PDF »

Cu/Zn Superoxide Dismutase Plays Important Role in Immune Response.

M. Marikovsky, V. Ziv, N. Nevo, C. Harris-Cerruti, and O. Mahler (2003)
J. Immunol. 170, 2993-3001
 |  Abstract »  |  Full Text »  |  PDF »

Arginine-Rich Cationic Polypeptides Amplify Lipopolysaccharide-Induced Monocyte Activation.

H. Bosshart and M. Heinzelmann (2002)
Infect. Immun. 70, 6904-6910
 |  Abstract »  |  Full Text »  |  PDF »

HMGB1 as a DNA-binding cytokine.

U. Andersson, H. Erlandsson-Harris, H. Yang, and K. J. Tracey (2002)
J. Leukoc. Biol. 72, 1084-1091
 |  Abstract »  |  Full Text »  |  PDF »

Inflammatory Mediators and the Failing Heart: Past, Present, and the Foreseeable Future.

D. L. Mann (2002)
Circ. Res. 91, 988-998
 |  Abstract »  |  Full Text »  |  PDF »

Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation.

L. Ulloa, M. Ochani, H. Yang, M. Tanovic, D. Halperin, R. Yang, C. J. Czura, M. P. Fink, and K. J. Tracey (2002)
PNAS 99, 12351-12356
 |  Abstract »  |  Full Text »  |  PDF »

Tumor necrosis factor-alpha activation by adenovirus E1A 13S CR3 occurs in a cell-dependent and cell-independent manner.

T. A. Sanchez, J. L. Booth, and J. P. Metcalf (2002)
Am J Physiol Lung Cell Mol Physiol 283, L619-L627
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle.

R. A. Frost, G. J. Nystrom, and C. H. Lang (2002)
Am J Physiol Regulatory Integrative Comp Physiol 283, R698-R709
 |  Abstract »  |  Full Text »  |  PDF »

Innate immunity and cardiac preconditioning: a putative intrinsic cardioprotective program.

R. M Smith, S. Lecour, and M. N Sack (2002)
Cardiovasc Res 55, 474-482
 |  Abstract »  |  Full Text »  |  PDF »

Staphylococcal enterotoxin B induces hepatic injury and lethal shock in endotoxin-resistant C3H/HeJ mice despite a deficient macrophage response.

S. Yasuda, M. Nagaki, and H. Moriwaki (2002)
Innate Immunity 8, 253-261
 |  Abstract »  |  PDF »

Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy.

J. Staelens, B. Wielockx, L. Puimege, F. Van Roy, J.-L. Guenet, and C. Libert (2002)
PNAS 99, 9340-9345
 |  Abstract »  |  Full Text »  |  PDF »

Macrolide-treated Pseudomonas aeruginosa induces paradoxical host responses in the lungs of mice and a high mortality rate.

T. Kobayashi, K. Tateda, T. Matsumoto, S. Miyazaki, A. Watanabe, T. Nukiwa, and K. Yamaguchi (2002)
J. Antimicrob. Chemother. 50, 59-66
 |  Abstract »  |  Full Text »  |  PDF »

Bacterial Peptidoglycan-associated Lipoprotein Is Released into the Bloodstream in Gram-negative Sepsis and Causes Inflammation and Death in Mice.

J. Hellman, J. D. Roberts Jr., M. M. Tehan, J. E. Allaire, and H. S. Warren (2002)
J. Biol. Chem. 277, 14274-14280
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacological Stimulation of the Cholinergic Antiinflammatory Pathway.

T. R. Bernik, S. G. Friedman, M. Ochani, R. DiRaimo, L. Ulloa, H. Yang, S. Sudan, C. J. Czura, S. M. Ivanova, and K. J. Tracey (2002)
J. Exp. Med. 195, 781-788
 |  Abstract »  |  Full Text »  |  PDF »

Antithrombin prevents endotoxin-induced hypotension by inhibiting the induction of nitric oxide synthase in rats.

H. Isobe, K. Okajima, M. Uchiba, N. Harada, and H. Okabe (2002)
Blood 99, 1638-1645
 |  Abstract »  |  Full Text »  |  PDF »

TNF-alpha disruption of lung endothelial integrity: reduced integrin mediated adhesion to fibronectin.

R. F. Rotundo, T. M. Curtis, M. D. Shah, B. Gao, A. Mastrangelo, S. E. LaFlamme, and T. M. Saba (2002)
Am J Physiol Lung Cell Mol Physiol 282, L316-L329
 |  Abstract »  |  Full Text »  |  PDF »

TNF-alpha -dependent bilateral renal injury is induced by unilateral renal ischemia-reperfusion.

K. K. Meldrum, D. R. Meldrum, X. Meng, L. Ao, and A. H. Harken (2002)
Am J Physiol Heart Circ Physiol 282, H540-H546
 |  Abstract »  |  Full Text »  |  PDF »

HMGB1 as a Late Mediator of Lethal Systemic Inflammation.

H. WANG, H. YANG, C. J. CZURA, A. E. SAMA, and K. J. TRACEY (2001)
Am. J. Respir. Crit. Care Med. 164, 1768-1773
 |  Full Text »  |  PDF »

Comparative Analysis of Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Activity in Serum and Lethality in Mice and Rabbits Pretreated with the Staphylococcal Superantigen Toxic Shock Syndrome Toxin 1.

M. M. Dinges and P. M. Schlievert (2001)
Infect. Immun. 69, 7169-7172
 |  Abstract »  |  Full Text »  |  PDF »

Coexpressed Nitric Oxide Synthase and Apical {beta}1 Integrins Influence Tubule Cell Adhesion after Cytokine-Induced Injury.

P. A. GLYNNE, J. PICOT, and T. J. EVANS (2001)
J. Am. Soc. Nephrol. 12, 2370-2383
 |  Abstract »  |  Full Text »  |  PDF »

Preclinical Studies to Predict the Disposition of Apo2L/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Humans: Characterization of in Vivo Efficacy, Pharmacokinetics, and Safety.

S. K. Kelley, L. A. Harris, D. Xie, L. DeForge, K. Totpal, J. Bussiere, and J. A. Fox (2001)
J. Pharmacol. Exp. Ther. 299, 31-38
 |  Abstract »  |  Full Text »  |  PDF »

Norepinephrine-induced hepatocellular dysfunction in early sepsis is mediated by activation of alpha 2-adrenoceptors.

S. Yang, M. Zhou, I. H. Chaudry, and P. Wang (2001)
Am J Physiol Gastrointest Liver Physiol 281, G1014-G1021
 |  Abstract »  |  Full Text »  |  PDF »

Synergistic effects of tumor necrosis factor-{alpha} and thrombin in increasing endothelial permeability.

C. Tiruppathi, T. Naqvi, R. Sandoval, D. Mehta, and A. B. Malik (2001)
Am J Physiol Lung Cell Mol Physiol 281, L958-L968
 |  Abstract »  |  Full Text »  |  PDF »

Activated Protein C Prevents Endotoxin-Induced Hypotension in Rats by Inhibiting Excessive Production of Nitric Oxide.

H. Isobe, K. Okajima, M. Uchiba, A. Mizutani, N. Harada, A. Nagasaki, and K. Okabe (2001)
Circulation 104, 1171-1175
 |  Abstract »  |  Full Text »  |  PDF »

A low level of TNF-{alpha} mediates hemorrhage-induced acute lung injury via p55 TNF receptor.

Y. Song, L. Ao, C. D. Raeburn, C. M. Calkins, E. Abraham, A. H. Harken, and X. Meng (2001)
Am J Physiol Lung Cell Mol Physiol 281, L677-L684
 |  Abstract »  |  Full Text »  |  PDF »

Continuous Leakage Measurement During Hyperthermic Isolated Limb Perfusion.

D. Daryanani, R. Komdeur, J. Ter Veen, P.H. Nijhuis, D.A. Piers, and H.J. Hoekstra (2001)
Ann. Surg. Oncol. 8, 566-572
 |  Abstract »  |  Full Text »  |  PDF »

Cytokines in Clinical Psychiatry.

L. CAPURON, R.-M. BLUTHE, and R. DANTZER (2001)
Am J Psychiatry 158, 1163
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Drs. Kronfol and Remick Reply.

Z. KRONFOL and D. G. REMICK (2001)
Am J Psychiatry 158, 1163-1164
 |  Full Text »

Mind over immunity.

K. J. TRACEY, C. J. CZURA, and S. IVANOVA (2001)
FASEB J 15, 1575-1576
 |  Abstract »  |  Full Text »  |  PDF »

Superantigen antagonist blocks Th1 cytokine gene induction and lethal shock.

G. Arad, D. Hillman, R. Levy, and R. Kaempfer (2001)
J. Leukoc. Biol. 69, 921-927
 |  Abstract »  |  Full Text »  |  PDF »

Neutrophil adhesion is impaired in the mesentery but not in the liver sinusoids of portal hypertensive rats.

S. Perez-del-Pulgar, P. Pizcueta, P. Engel, J. Bosch, and J. Rodes (2001)
Am J Physiol Gastrointest Liver Physiol 280, G1351-G1359
 |  Abstract »  |  Full Text »  |  PDF »

Countervailing Influence of Tumor Necrosis Factor-{{alpha}} and Nitric Oxide in Endotoxemia.

E. A. JAIMES, D. D. CASTILLO, M. S. RUTHERFORD, and L. RAIJ (2001)
J. Am. Soc. Nephrol. 12, 1204-1210
 |  Abstract »  |  Full Text »

IL-10-Deficient Mice Demonstrate Multiple Organ Failure and Increased Mortality During Escherichia coli Peritonitis Despite an Accelerated Bacterial Clearance.

M. E. Sewnath, D. P. Olszyna, R. Birjmohun, F. J. W. ten Kate, D. J. Gouma, and T. van der Poll (2001)
J. Immunol. 166, 6323-6331
 |  Abstract »  |  Full Text »  |  PDF »

Effects of soluble TNF receptor treatment on lipopolysaccharide-induced myocardial cytokine expression.

T. Kadokami, C. F. McTiernan, T. Kubota, C. S. Frye, G. S. Bounoutas, P. D. Robbins, S. C. Watkins, and A. M. Feldman (2001)
Am J Physiol Heart Circ Physiol 280, H2281-H2291
 |  Abstract »  |  Full Text »  |  PDF »

The Sole Gateway to Endotoxin Response: How Lps Was Identified as Tlr4, and Its Role in Innate Immunity.

B. Beutler and A. Poltorak (2001)
Drug Metab. Dispos. 29, 474-478
 |  Abstract »  |  Full Text »

The systemic inflammatory response syndrome.

H. Meeran and M. Messent (2001)
Trauma 3, 89-100
 |  Abstract »  |  PDF »

Role of Tumor Necrosis Factor on Toxicity and Cytokine Production after Isolated Hepatic Perfusion.

T. E. Lans, D. L. Bartlett, S. K. Libutti, M. F.X. Gnant, D. J. Liewehr, D. J. Venzon, E. M. Turner, and H. R. Alexander (2001)
Clin. Cancer Res. 7, 784-790
 |  Abstract »  |  Full Text »

Reduced Early Alcohol-Induced Liver Injury in CD14-Deficient Mice.

M. Yin, B. U. Bradford, M. D. Wheeler, T. Uesugi, M. Froh, S. M. Goyert, and R. G. Thurman (2001)
J. Immunol. 166, 4737-4742
 |  Abstract »  |  Full Text »  |  PDF »

TNF-{alpha} induces protein synthesis through PI3-kinase-Akt/PKB pathway in cardiac myocytes.

E. Hiraoka, S. Kawashima, T. Takahashi, Y. Rikitake, T. Kitamura, W. Ogawa, and M. Yokoyama (2001)
Am J Physiol Heart Circ Physiol 280, H1861-H1868
 |  Abstract »  |  Full Text »  |  PDF »

Role of T Cells and Gamma Interferon during Induction of Hypersensitivity to Lipopolysaccharide by Toxic Shock Syndrome Toxin 1 in Mice.

M. M. Dinges and P. M. Schlievert (2001)
Infect. Immun. 69, 1256-1264
 |  Abstract »  |  Full Text »  |  PDF »

Superantigens: The Good, the Bad, and the Ugly.

B. A. Torres, S. Kominsky, G. Q. Perrin, A. C. Hobeika, and H. M. Johnson (2001)
Experimental Biology and Medicine 226, 164-176
 |  Abstract »  |  Full Text »

Triggering of Antitumor Activity Through Melanoma-specific Transduction of a Constitutively Active Tumor Necrosis Factor (TNF) R1 Chimeric Receptor in the Absence of TNF-{{alpha}}.

F. Bazzoni and E. Regalia (2001)
Cancer Res. 61, 1050-1057
 |  Abstract »  |  Full Text »

Novel Nonantibiotic Therapies for Pneumonia : Cytokines and Host Defense.

S. Nelson (2001)
Chest 119, 419S-425S
 |  Abstract »  |  Full Text »  |  PDF »

Gut-derived norepinephrine plays a critical role in producing hepatocellular dysfunction during early sepsis.

S. Yang, D. J. Koo, M. Zhou, I. H. Chaudry, and P. Wang (2000)
Am J Physiol Gastrointest Liver Physiol 279, G1274-G1281
 |  Abstract »  |  Full Text »  |  PDF »

Morphine enhances interleukin-12 and the production of other pro-inflammatory cytokines in mouse peritoneal macrophages.

X. Peng, D. M. Mosser, M. W. Adler, T. J. Rogers, J. J. Meissler Jr, and T. K. Eisenstein (2000)
J. Leukoc. Biol. 68, 723-728
 |  Abstract »  |  Full Text »

High Mobility Group 1 Protein (HMG-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes.

U. Andersson, H. Wang, K. Palmblad, A.-C. Aveberger, O. Bloom, H. Erlandsson-Harris, A. Janson, R. Kokkola, M. Zhang, H. Yang, et al. (2000)
J. Exp. Med. 192, 565-570
 |  Abstract »  |  Full Text »  |  PDF »

TNF-Induced Shedding of TNF Receptors in Human Polymorphonuclear Leukocytes: Role of the 55-kDa TNF Receptor and Involvement of a Membrane-Bound and Non-Matrix Metalloproteinase.

P. Dri, C. Gasparini, R. Menegazzi, R. Cramer, L. Alberi, G. Presani, S. Garbisa, and P. Patriarca (2000)
J. Immunol. 165, 2165-2172
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Bile Mediates Intestinal Pathology in Endotoxemia in Rats.

G. D. F. Jackson, Y. Dai, and W. A. Sewell (2000)
Infect. Immun. 68, 4714-4719
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Dietary glycine blunts lung inflammatory cell influx following acute endotoxin.

M. D. Wheeler, M. L. Rose, S. Yamashima, N. Enomoto, V. Seabra, J. Madren, and R. G. Thurman (2000)
Am J Physiol Lung Cell Mol Physiol 279, L390-L398
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Tumor Necrosis Factor Alpha-Mediated Toxic Shock in Trypanosoma cruzi-Infected Interleukin 10-Deficient Mice.

C. Holscher, M. Mohrs, W. J. Dai, G. Kohler, B. Ryffel, G. A. Schaub, H. Mossmann, and F. Brombacher (2000)
Infect. Immun. 68, 4075-4083
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"Emergency" granulopoiesis in G-CSF-deficient mice in response to Candida albicans infection.

S. Basu, G. Hodgson, H.-H. Zhang, M. Katz, C. Quilici, and A. R. Dunn (2000)
Blood 95, 3725-3733
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LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-alpha.

J. Xaus, M. Comalada, A. F. Valledor, J. Lloberas, F. Lopez-Soriano, J. M. Argiles, C. Bogdan, and A. Celada (2000)
Blood 95, 3823-3831
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Carcinoembryonic Antigen Family Receptor Specificity of Neisseria meningitidis Opa Variants Influences Adherence to and Invasion of Proinflammatory Cytokine-Activated Endothelial Cells.

P. Muenzner, C. Dehio, T. Fujiwara, M. Achtman, T. F. Meyer, and S. D. Gray-Owen (2000)
Infect. Immun. 68, 3601-3607
 |  Abstract »  |  Full Text »  |  PDF »

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