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Science 24 October 1986:
Vol. 234. no. 4775, pp. 470 - 474
DOI: 10.1126/science.3764421
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Articles

Science, Vol 234, Issue 4775, 470-474
Copyright © 1986 by American Association for the Advancement of Science

articles

Shock and tissue injury induced by recombinant human cachectin

KJ Tracey, B Beutler, SF Lowry, J Merryweather, S Wolpe, IW Milsark, RJ Hariri, TJ Fahey 3rd, A Zentella, JD Albert, and al. et

Cachectin (tumor necrosis factor), a protein produced in large quantities by endotoxin-activated macrophages, has been implicated as an important mediator of the lethal effect of endotoxin. Recombinant human cachectin was infused into rats in an effort to determine whether cachectin, by itself, can elicit the derangements of host physiology caused by administration of endotoxin. When administered in quantities similar to those produced endogenously in response to endotoxin, cachectin causes hypotension, metabolic acidosis, hemoconcentration, and death within minutes to hours, as a result of respiratory arrest. Hyperglycemia and hyperkalemia were also observed after infusion. At necropsy, diffuse pulmonary inflammation and hemorrhage were apparent on gross and histopathologic examination, along with ischemic and hemorrhagic lesions of the gastrointestinal tract, and acute renal tubular necrosis. Thus, it appears that a single protein mediator (cachectin) is capable of inducing many of the deleterious effects of endotoxin.


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S. Yang, D. J. Koo, M. Zhou, I. H. Chaudry, and P. Wang (2000)
Am J Physiol Gastrointest Liver Physiol 279, G1274-G1281
   Abstract »    Full Text »    PDF »
Morphine enhances interleukin-12 and the production of other pro-inflammatory cytokines in mouse peritoneal macrophages.
X. Peng, D. M. Mosser, M. W. Adler, T. J. Rogers, J. J. Meissler Jr, and T. K. Eisenstein (2000)
J. Leukoc. Biol. 68, 723-728
   Abstract »    Full Text »
High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes.
U. Andersson, H. Wang, K. Palmblad, A.-C. Aveberger, O. Bloom, H. Erlandsson-Harris, A. Janson, R. Kokkola, M. Zhang, H. Yang, et al. (2000)
J. Exp. Med. 192, 565-570
   Abstract »    Full Text »    PDF »
TNF-Induced Shedding of TNF Receptors in Human Polymorphonuclear Leukocytes: Role of the 55-kDa TNF Receptor and Involvement of a Membrane-Bound and Non-Matrix Metalloproteinase.
P. Dri, C. Gasparini, R. Menegazzi, R. Cramer, L. Alberi, G. Presani, S. Garbisa, and P. Patriarca (2000)
J. Immunol. 165, 2165-2172
   Abstract »    Full Text »    PDF »
Bile Mediates Intestinal Pathology in Endotoxemia in Rats.
G. D. F. Jackson, Y. Dai, and W. A. Sewell (2000)
Infect. Immun. 68, 4714-4719
   Abstract »    Full Text »    PDF »
Dietary glycine blunts lung inflammatory cell influx following acute endotoxin.
M. D. Wheeler, M. L. Rose, S. Yamashima, N. Enomoto, V. Seabra, J. Madren, and R. G. Thurman (2000)
Am J Physiol Lung Cell Mol Physiol 279, L390-L398
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor Alpha-Mediated Toxic Shock in Trypanosoma cruzi-Infected Interleukin 10-Deficient Mice.
C. Holscher, M. Mohrs, W. J. Dai, G. Kohler, B. Ryffel, G. A. Schaub, H. Mossmann, and F. Brombacher (2000)
Infect. Immun. 68, 4075-4083
   Abstract »    Full Text »    PDF »


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