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Science 24 October 1986:
Vol. 234. no. 4775, pp. 467 - 470
DOI: 10.1126/science.3532322
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Articles

Science, Vol 234, Issue 4775, 467-470
Copyright © 1986 by American Association for the Advancement of Science

articles

Participation of c-myc protein in DNA synthesis of human cells

GP Studzinski, ZS Brelvi, SC Feldman, and RA Watt

The protein product of oncogene c-myc is believed to be important in regulation of the cell cycle. However, its direct role in DNA synthesis has not been explored. Experiments presented here show that the addition of affinity-purified antibodies against the human c-myc protein to nuclei isolated from several types of human cells reversibly inhibited DNA synthesis and DNA polymerase activity of these nuclei. This suggests that c-myc encodes a protein that is functionally involved in DNA synthesis.


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Aging and Photoaging Affect Gene Expression in Cultured Human Keratinocytes.
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The approaching era of the tumor suppressor genes.
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The molecular genetics of cancer.
J. Bishop (1987)
Science 235, 305-311
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Colocalization of the myc Oncogene Protein and Small Nuclear Ribonucleoprotein Particles.
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