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Science 24 October 1986:
Vol. 234. no. 4775, pp. 438 - 443
DOI: 10.1126/science.2945253

Articles

Science, Vol 234, Issue 4775, 438-443
Copyright © 1986 by American Association for the Advancement of Science


articles

The trans Golgi network: sorting at the exit site of the Golgi complex

G Griffiths and K Simons

The Golgi complex is a series of membrane compartments through which proteins destined for the plasma membrane, secretory vesicles, and lysosomes move sequentially. A model is proposed whereby these three different classes of proteins are sorted into different vesicles in the last Golgi compartment, the trans Golgi network. This compartment corresponds to a tubular reticulum on the trans side of the Golgi stack, previously called Golgi endoplasmic reticulum lysosomes (GERL).


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Secretory pathway kinetics and in vivo analysis of protein traffic from the Golgi complex to the cell surface.
K. HIRSCHBERG and J. LIPPINCOTT-SCHWARTZ (1999)
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Structural Maturation of the Transmissible Gastroenteritis Coronavirus.
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Genetic Analysis of the Role of Herpes Simplex Virus Type 1 Glycoprotein K in Infectious Virus Production and Egress.
T. P. Foster and K. G. Kousoulas (1999)
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Further studies of the glandular tissue of the Sauromatum guttatum (Araceae) appendix.
H. Skubatz and D. D. Kunkel (1999)
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Fas ligand, Fas antigen and Bcl-2 expression in human endometrium during the menstrual cycle.
H. Yamashita, Y. Otsuki, Y. Ito, K. Matsumoto, K. Ueki, and M. Ueki (1999)
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Golgi Structure in Three Dimensions: Functional Insights from the Normal Rat Kidney Cell.
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Insulin stimulation of rat ventricular K+ currents depends on the integrity of the cytoskeleton.
Y Shimoni, H S Ewart, and D Severson (1999)
J. Physiol. 514, 735-745
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TNF Recruits TRADD to the Plasma Membrane But Not the trans-Golgi Network, the Principal Subcellular Location of TNF-R1.
S. J. Jones, E. C. Ledgerwood, J. B. Prins, J. Galbraith, D. R. Johnson, J. S. Pober, and J. R. Bradley (1999)
J. Immunol. 162, 1042-1048
   Abstract »    Full Text »    PDF »
Membrane flow through the Golgi apparatus: specific disassembly of the cis-Golgi network by ATP depletion.
M del Valle, Y Robledo, and I. Sandoval (1999)
J. Cell Sci. 112, 4017-4029
   Abstract »    PDF »
N-Ras induces alterations in Golgi complex architecture and in constitutive protein transport.
T Babia, I Ayala, F Valderrama, E Mato, M Bosch, J. Santaren, J Renau-Piqueras, J. Kok, T. Thomson, and G Egea (1999)
J. Cell Sci. 112, 477-489
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Dual-color visualization of trans-Golgi network to plasma membrane traffic along microtubules in living cells.
D Toomre, P Keller, J White, J. Olivo, and K Simons (1999)
J. Cell Sci. 112, 21-33
   Abstract »    PDF »
Kinetic Analysis of Secretory Protein Traffic and Characterization of Golgi to Plasma Membrane Transport Intermediates in Living Cells.
K. Hirschberg, C. M. Miller, J. Ellenberg, J. F. Presley, E. D. Siggia, R. D. Phair, and J. Lippincott-Schwartz (1998)
J. Cell Biol. 143, 1485-1503
   Abstract »    Full Text »    PDF »
Analysis of GLUT4 Distribution in Whole Skeletal Muscle Fibers: Identification of Distinct Storage Compartments That Are Recruited by Insulin and Muscle Contractions.
T. Ploug, B. van Deurs, H. Ai, S. W. Cushman, and E. Ralston (1998)
J. Cell Biol. 142, 1429-1446
   Abstract »    Full Text »    PDF »
The SNARE Machinery Is Involved in Apical Plasma Membrane Trafficking in MDCK Cells.
S. H. Low, S. J. Chapin, C. Wimmer, S. W. Whiteheart, L. G. Komuves, K. E. Mostov, and T. Weimbs (1998)
J. Cell Biol. 141, 1503-1513
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Intracellular Transport of the Glycoproteins gE and gI of the Varicella-Zoster Virus. gE ACCELERATES THE MATURATION OF gI AND DETERMINES ITS ACCUMULATION IN THE TRANS-GOLGI NETWORK.
A. Alconada, U. Bauer, L. Baudoux, J. Piette, and B. Hoflack (1998)
J. Biol. Chem. 273, 13430-13436
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A Phosphatidylinositol 3-Kinase and Phosphatidylinositol Transfer Protein Act Synergistically in Formation of Constitutive Transport Vesicles from the Trans-Golgi Network.
S. M. Jones, J. G. Alb Jr., S. E. Phillips, V. A. Bankaitis, and K. E. Howell (1998)
J. Biol. Chem. 273, 10349-10354
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Caveolin-1 and -2 in the Exocytic Pathway of MDCK Cells.
P. Scheiffele, P. Verkade, A.M. Fra, H. Virta, K. Simons, and E. Ikonen (1998)
J. Cell Biol. 140, 795-806
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Cells Transfected with a Non-Neutralizing Antibody Gene Are Resistant to HIV Infection: Targeting the Endoplasmic Reticulum and Trans-Golgi Network.
P. Zhou, S. Goldstein, K. Devadas, D. Tewari, and A. L. Notkins (1998)
J. Immunol. 160, 1489-1496
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Nordihydroguaiaretic Acid Blocks Protein Transport in the Secretory Pathway Causing Redistribution of Golgi Proteins into the Endoplasmic Reticulum.
T. Fujiwara, N. Takami, Y. Misumi, and Y. Ikehara (1998)
J. Biol. Chem. 273, 3068-3075
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Protein transport from the endoplasmic reticulum to the Golgi apparatus.
W Hong (1998)
J. Cell Sci. 111, 2831-2839
   Abstract »    PDF »
Retrograde trafficking of both Golgi complex and TGN markers to the ER induced by nordihydroguaiaretic acid and cyclofenil diphenol.
D Drecktrah, P de Figueiredo, R. Mason, and W. Brown (1998)
J. Cell Sci. 111, 951-965
   Abstract »    PDF »
The GM2-1 Ganglioside Islet Autoantigen in Insulin-Dependent Diabetes Mellitus Is Expressed in Secretory Granules and Is Not {beta}-Cell Specific.
F. Dotta, M. Previti, M. Neerman-Arbez, S. Dionisi, D. Cucinotta, L. Lenti, U. Di Mario, and P. A. Halban (1998)
Endocrinology 139, 316-319
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Cytoskeletal Protein ABP-280 Directs the Intracellular Trafficking of Furin and Modulates Proprotein Processing in the Endocytic Pathway.
G. Liu, L. Thomas, R. A. Warren, C. A. Enns, C. C. Cunningham, J. H. Hartwig, and G. Thomas (1997)
J. Cell Biol. 139, 1719-1733
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Adenovirally Encoded Prohormone Convertase-1 Functions in Atrial Myocyte Large Dense Core Vesicles.
R. Marx and R. E. Mains (1997)
Endocrinology 138, 5108-5118
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Involvement of the Transmembrane Protein p23 in Biosynthetic Protein Transport.
M. Rojo, R. Pepperkok, G. Emery, R. Kellner, E. Stang, R. G. Parton, and J. Gruenberg (1997)
J. Cell Biol. 139, 1119-1135
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Molecular Motors and a Spectrin Matrix Associate with Golgi Membranes In Vitro.
K. R. Fath, G. M. Trimbur, and D. R. Burgess (1997)
J. Cell Biol. 139, 1169-1181
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Membrane Cofactor Protein (CD46) Is a Basolateral Protein That Is Not Endocytosed. IMPORTANCE OF THE TETRAPEPTIDE FTSL AT THE CARBOXYL TERMINUS.
A. Maisner, G. Zimmer, M. K. Liszewski, D. M. Lublin, J. P. Atkinson, and G. Herrler (1997)
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Disruption of Microtubules Reveals Two Independent Apical Targeting Mechanisms for G-protein-coupled Receptors in Polarized Renal Epithelial Cells.
C. Saunders and L. E. Limbird (1997)
J. Biol. Chem. 272, 19035-19045
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Glucose Transporter (GLUT-4) Is Targeted to Secretory Granules in Rat Atrial Cardiomyocytes.
J. W. Slot, G. Garruti, S. Martin, V. Oorschot, G. Posthuma, E. W. Kraegen, R. Laybutt, G. Thibault, and D. E. James (1997)
J. Cell Biol. 137, 1243-1254
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Partitioning of the Golgi Apparatus during Mitosis in Living HeLa Cells.
D. T. Shima, K. Haldar, R. Pepperkok, R. Watson, and G. Warren (1997)
J. Cell Biol. 137, 1211-1228
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Mechanisms for de novo biogenesis of an apical membrane compartment in groups of simple epithelial cells surrounded by extracellular matrix.
G. Ojakian, W. Nelson, and K. Beck (1997)
J. Cell Sci. 110, 2781-2794
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Golgi membrane skeleton: identification, localization and oligomerization of a 195 kDa ankyrin isoform associated with the Golgi complex.
K. Beck, J. Buchanan, and W. Nelson (1997)
J. Cell Sci. 110, 1239-1249
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Two Different Cytoplasmic Tails Direct Isoforms of the Membrane Cofactor Protein (CD46) to the Basolateral Surface of Madin-Darby Canine Kidney Cells.
A. Maisner, M. K. Liszewski, J. P. Atkinson, R. Schwartz-Albiez, and G. Herrler (1996)
J. Biol. Chem. 271, 18853-18858
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Ultrastructural Localization of the Vesicular Monoamine Transporter-2 in Midbrain Dopaminergic Neurons: Potential Sites for Somatodendritic Storage and Release of Dopamine.
M. J. Nirenberg, J. Chan, Y. Liu, R. H. Edwards, and V. M. Pickel (1996)
J. Neurosci. 16, 4135-4145
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Primate homologues of rat TGN38: primary structure, expression and functional implications.
S. Ponnambalam, M. Girotti, M. L. Yaspo, C. E. Owen, A. C. Perry, T. Suganuma, T. Nilsson, M. Fried, G. Banting, and G. Warren (1996)
J. Cell Sci. 109, 675-685
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A Casein Kinase II Phosphorylation Site in the Cytoplasmic Domain of the Cation-dependent Mannose 6-Phosphate Receptor Determines the High Affinity Interaction of the AP-1 Golgi Assembly Proteins with Membranes.
F. Mauxion, R. Le Borgne, Hélèn. Munier-Lehmann, and B. Hoflack (1996)
J. Biol. Chem. 271, 2171-2178
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Involvement of the vacuolar proton-translocating ATPase in multiple steps of the endo-lysosomal system and in the contractile vacuole system of Dictyostelium discoideum.
L. Temesvari, J. Rodriguez-Paris, J. Bush, L Zhang, and J. Cardelli (1996)
J. Cell Sci. 109, 1479-1495
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Three-dimensional organization of rat hepatocyte cytoskeleton: relation to the asialoglycoprotein endocytosis pathway.
P. Novikoff, M Cammer, L Tao, H Oda, R. Stockert, A. Wolkoff, and P Satir (1996)
J. Cell Sci. 109, 21-32
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Strain-specific Presence of Two TGN38 Isoforms and Absence of TGN41 in Mouse.
K. Kasai, S. Takahashi, K. Murakami, and K. Nakayama (1995)
J. Biol. Chem. 270, 14471-14476
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Newly Synthesized Transferrin Receptors Can Be Detected in the Endosome before They Appear on the Cell Surface.
C. E. Futter, C. N. Connolly, D. F. Cutler, and C. R. Hopkins (1995)
J. Biol. Chem. 270, 10999-11003
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Direct Measurement of trans-Golgi pH in Living Cells and Regulation by Second Messengers.
O. Seksek, J. Biwersi, and A. S. Verkman (1995)
J. Biol. Chem. 270, 4967-4970
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A Novel Method to Co-localize Glycosaminoglycan-Core Oligosaccharide Glycosyltransferases in Rat Liver Golgi.
J. R. Etchison, G. Srikrishna, and H. H. Freeze (1995)
J. Biol. Chem. 270, 756-764
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Monoclonal antibody HFD9 identifies a novel 28 kDa integral membrane protein on the cis-Golgi.
V. Subramaniam, J Krijnse-Locker, B. Tang, M Ericsson, A. Yusoff, G Griffiths, and W Hong (1995)
J. Cell Sci. 108, 2405-2414
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Communication of post-Golgi elements with early endocytic pathway: regulation of endoproteolytic cleavage of Semliki Forest virus p62 precursor.
M Sariola, J Saraste, and E Kuismanen (1995)
J. Cell Sci. 108, 2465-2475
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Regulation of Post-Golgi Vesicle Production in an In Vitro System.
J.-P. Simon, I.E. Ivanov, M. Ren, J. Zeng, B. Shopsin, D. Hersh, P. Tempst, H. Erdjument-Bromage, M. Lui, C. De Lemos-Chiarandini, et al. (1995)
Cold Spring Harb Symp Quant Biol 60, 179-195
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Biogenesis of Neurosecretory Vesicles.
W.B. Huttner, M. Ohashi, R.H. Kehlenbach, F.A. Barr, R. Bauerfeind, O. Braunling, D. Corbeil, M. Hannah, H.A. Pasolli, A. Schmidt, et al. (1995)
Cold Spring Harb Symp Quant Biol 60, 315-327
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Mitotic Disassembly and Reassembly of the Golgi Apparatus.
T.P. Levine, T. Misteli, C. Rabouille, and G. Warren (1995)
Cold Spring Harb Symp Quant Biol 60, 549-557
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Two proteins associated with secretory granule membranes identified in chicken regulated secretory cells.
J. Thomas, A Stieber, and N Gonatas (1994)
J. Cell Sci. 107, 1297-1308
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The intracellular mobility of a viral membrane glycoprotein measured by confocal microscope fluorescence recovery after photobleaching.
B Storrie, R Pepperkok, E. Stelzer, and T. Kreis (1994)
J. Cell Sci. 107, 1309-1319
   Abstract »    PDF »
Brefeldin A causes structural and functional alterations of the trans-Golgi network of MDCK cells.
M Wagner, A. Rajasekaran, D. Hanzel, S Mayor, and E Rodriguez-Boulan (1994)
J. Cell Sci. 107, 933-943
   Abstract »    PDF »
Molecular chaperones in pancreatic tissue: the presence of cpn10, cpn60 and hsp70 in distinct compartments along the secretory pathway of the acinar cells.
C. Velez-Granell, A. Arias, J. Torres-Ruiz, and M Bendayan (1994)
J. Cell Sci. 107, 539-549
   Abstract »    PDF »
Differential effects of temperature blockade on the proteolytic processing of three secretory granule-associated proteins.
S. Milgram and R. Mains (1994)
J. Cell Sci. 107, 737-745
   Abstract »    PDF »
Rab6 is associated with a compartment that transports rhodopsin from the trans-Golgi to the site of rod outer segment disk formation in frog retinal photoreceptors.
D Deretic and D. Papermaster (1993)
J. Cell Sci. 106, 803-813
   Abstract »    PDF »



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