Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Policy Alerts

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 17 October 1986:
Vol. 234. no. 4774, pp. 358 - 361
DOI: 10.1126/science.3764416
Prev | Table of Contents | Next

Articles

Science, Vol 234, Issue 4774, 358-361
Copyright © 1986 by American Association for the Advancement of Science

articles

Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin

Y Sugiura, CL Lee, and ER Perl

Unmyelinated (C) fibers are the most numerous sensory elements of mammalian peripheral nerve and comprise many of those responsible for initiating pain and temperature reactions; however, direct evidence has been lacking as to where and how these fibers terminate in the central nervous system. A plant lectin (Phaseolus vulgaris leukoagglutinin) was applied intracellularly by iontophoresis as an immunocytochemical marker. This permitted visualization of the central terminations of cutaneous C sensory fibers that had been identified by the nature of stimuli that excited them. The central branch of C-fiber units arborized and terminated mainly in the superficial layers of the spinal dorsal horn in defined patterns that related to their functional attributes. Thus, the superficial dorsal horn seems to act as a processing station for signals from fine sensory fibers.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Demystifying acupuncture.
D. Pyne and N. G. Shenker (2008)
Rheumatology 47, 1132-1136
   Abstract »    Full Text »    PDF »
Activation of GIRK channels in substantia gelatinosa neurones of the adult rat spinal cord: a possible involvement of somatostatin.
T. Nakatsuka, T. Fujita, K. Inoue, and E. Kumamoto (2008)
J. Physiol. 586, 2511-2522
   Abstract »    Full Text »    PDF »
Recording Temperature Affects the Excitability of Mouse Superficial Dorsal Horn Neurons, In Vitro.
B. A. Graham, A. M. Brichta, and R. J. Callister (2008)
J Neurophysiol 99, 2048-2059
   Abstract »    Full Text »    PDF »
Synaptic Wiring in the Deep Dorsal Horn. Focus on "Local Circuit Connections Between Hamster Laminae III and IV Dorsal Horn Neurons".
Y. Lu (2008)
J Neurophysiol 99, 1051-1052
   Full Text »    PDF »
Myelinated Skin Sensory Neurons Project Extensively throughout Adult Mouse Substantia Gelatinosa.
M. D. Boada and C. J. Woodbury (2008)
J. Neurosci. 28, 2006-2014
   Abstract »    Full Text »    PDF »
Moving From an Averaged to Specific View of Spinal Cord Pain Processing Circuits.
B. A. Graham, A. M. Brichta, and R. J. Callister (2007)
J Neurophysiol 98, 1057-1063
   Abstract »    Full Text »    PDF »
Physiological Properties of Mouse Skin Sensory Neurons Recorded Intracellularly In Vivo: Temperature Effects on Somal Membrane Properties.
M. D. Boada and C. J. Woodbury (2007)
J Neurophysiol 98, 668-680
   Abstract »    Full Text »    PDF »
Selective action of noradrenaline and serotonin on neurones of the spinal superficial dorsal horn in the rat.
Y. Lu and E. R. Perl (2007)
J. Physiol. 582, 127-136
   Abstract »    Full Text »    PDF »
Excitatory interneurons dominate sensory processing in the spinal substantia gelatinosa of rat.
S. F. A. Santos, S. Rebelo, V. A. Derkach, and B. V. Safronov (2007)
J. Physiol. 581, 241-254
   Abstract »    Full Text »    PDF »
Differential wiring of local excitatory and inhibitory synaptic inputs to islet cells in rat spinal lamina II demonstrated by laser scanning photostimulation.
G. Kato, Y. Kawasaki, R.-R. Ji, and A. M. Strassman (2007)
J. Physiol. 580, 815-833
   Abstract »    Full Text »    PDF »
Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn.
B. K. Rycroft, K. S. Vikman, and M. J. Christie (2007)
J. Physiol. 580, 883-894
   Abstract »    Full Text »    PDF »
Clonidine reduces the excitability of spinal dorsal horn neurones.
M. Wolff, P. Heugel, G. Hempelmann, A. Scholz, J. Muhling, and A. Olschewski (2007)
Br. J. Anaesth. 98, 353-361
   Abstract »    Full Text »    PDF »
Placing pain on the sensory map: Classic papers by Ed Perl and colleagues.
P. Mason (2007)
J Neurophysiol 97, 1871-1873
   Abstract »    Full Text »    PDF »
Distinct Populations of Spinal Cord Lamina II Interneurons Expressing G-Protein-Gated Potassium Channels..
C. L. Marker, R. Lujan, J. Colon, and K. Wickman (2006)
J. Neurosci. 26, 12251-12259
   Abstract »    Full Text »    PDF »
Glial cell line-derived neurotrophic factor expression in skin alters the mechanical sensitivity of cutaneous nociceptors..
K. M. Albers, C. J. Woodbury, A. M. Ritter, B. M. Davis, and H. R. Koerber (2006)
J. Neurosci. 26, 2981-2990
   Abstract »    Full Text »    PDF »
Direct GABAergic and Glycinergic Inhibition of the Substantia Gelatinosa from the Rostral Ventromedial Medulla Revealed by In Vivo Patch-Clamp Analysis in Rats.
G. Kato, T. Yasaka, T. Katafuchi, H. Furue, M. Mizuno, Y. Iwamoto, and M. Yoshimura (2006)
J. Neurosci. 26, 1787-1794
   Abstract »    Full Text »    PDF »
Modular Organization of Excitatory Circuits between Neurons of the Spinal Superficial Dorsal Horn (Laminae I and II).
Y. Lu and E. R. Perl (2005)
J. Neurosci. 25, 3900-3907
   Abstract »    Full Text »    PDF »
Muscular mechanical hyperalgesia revealed by behavioural pain test and c-Fos expression in the spinal dorsal horn after eccentric contraction in rats.
T. Taguchi, T. Matsuda, R. Tamura, J. Sato, and K. Mizumura (2005)
J. Physiol. 564, 259-268
   Abstract »    Full Text »    PDF »
In vivo responses of mouse superficial dorsal horn neurones to both current injection and peripheral cutaneous stimulation.
B. A Graham, A. M Brichta, and R. J Callister (2004)
J. Physiol. 561, 749-763
   Abstract »    Full Text »    PDF »
Distribution and Injury-Induced Plasticity of Cadherins in Relationship to Identified Synaptic Circuitry in Adult Rat Spinal Cord.
J. H. Brock, A. Elste, and G. W. Huntley (2004)
J. Neurosci. 24, 8806-8817
   Abstract »    Full Text »    PDF »
Electrophysiological mapping of the nociceptive inputs to the substantia gelatinosa in rat horizontal spinal cord slices.
G. Kato, H. Furue, T. Katafuchi, T. Yasaka, Y. Iwamoto, and M. Yoshimura (2004)
J. Physiol. 560, 303-315
   Abstract »    Full Text »    PDF »
Mechanism of spike frequency adaptation in substantia gelatinosa neurones of rat.
I. V. Melnick, S. F. A. Santos, and B. V. Safronov (2004)
J. Physiol. 559, 383-395
   Abstract »    Full Text »    PDF »
Primary Afferent Stimulation Differentially Potentiates Excitatory and Inhibitory Inputs to Spinal Lamina II Outer and Inner Neurons.
Y.-Z. Pan and H.-L. Pan (2004)
J Neurophysiol 91, 2413-2421
   Abstract »    Full Text »    PDF »
The Effects of Pretreatment with Lidocaine or Bupivacaine on the Spatial and Temporal Expression of c-Fos Protein in the Spinal Cord Caused by Plantar Incision in the Rat.
X. Sun, M. Yokoyama, S. Mizobuchi, R. Kaku, H. Nakatsuka, T. Takahashi, and K. Morita (2004)
Anesth. Analg. 98, 1093-1098
   Abstract »    Full Text »    PDF »
Actions of noradrenaline on substantia gelatinosa neurones in the rat spinal cord revealed by in vivo patch recording.
M. Sonohata, H. Furue, T. Katafuchi, T. Yasaka, A. Doi, E. Kumamoto, and M. Yoshimura (2004)
J. Physiol. 555, 515-526
   Abstract »    Full Text »    PDF »
Cannabinoid-induced presynaptic inhibition at the primary afferent trigeminal synapse of juvenile rat brainstem slices.
Y.-C. Liang, C.-C. Huang, K.-S. Hsu, and T. Takahashi (2004)
J. Physiol. 555, 85-96
   Abstract »    Full Text »    PDF »
Ionic Basis of Tonic Firing in Spinal Substantia Gelatinosa Neurons of Rat.
I. V. Melnick, S. F. A. Santos, K. Szokol, P. Szucs, and B. V. Safronov (2004)
J Neurophysiol 91, 646-655
   Abstract »    Full Text »    PDF »
Morphological and Physiological Features of a Set of Spinal Substantia Gelatinosa Neurons Defined by Green Fluorescent Protein Expression.
A. W. Hantman, A. N. van den Pol, and E. R. Perl (2004)
J. Neurosci. 24, 836-842
   Abstract »    Full Text »    PDF »
A Specific Inhibitory Pathway between Substantia Gelatinosa Neurons Receiving Direct C-Fiber Input.
Y. Lu and E. R. Perl (2003)
J. Neurosci. 23, 8752-8758
   Abstract »    Full Text »    PDF »
Spinal Sensorimotor Transformation: Relation between Cutaneous Somatotopy and a Reflex Network.
A. Levinsson, H. Holmberg, J. Broman, M. Zhang, and J. Schouenborg (2002)
J. Neurosci. 22, 8170-8182
   Abstract »    Full Text »    PDF »
Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia.
W. Magerl, P. N. Fuchs, R. A. Meyer, and R.-D. Treede (2001)
Brain 124, 1754-1764
   Abstract »    Full Text »    PDF »
Mechanisms for Ovariectomy-Induced Hyperalgesia and Its Relief by Calcitonin: Participation of 5-HT1A-Like Receptor on C-Afferent Terminals in Substantia Gelatinosa of the Rat Spinal Cord.
A. Ito, E. Kumamoto, M. Takeda, M. Takeda, K. Shibata, H. Sagai, and M. Yoshimura (2000)
J. Neurosci. 20, 6302-6308
   Abstract »    Full Text »    PDF »
Physiological Properties of the Lamina I Spinoparabrachial Neurons in the Rat.
H. Bester, V. Chapman, J.-M. Besson, and J.-F. Bernard (2000)
J Neurophysiol 83, 2239-2259
   Abstract »    Full Text »    PDF »
Spinal Laminae I-II Neurons in Rat Recorded In Vivo in Whole Cell, Tight Seal Configuration: Properties and Opioid Responses.
A. R. Light and H. H. Willcockson (1999)
J Neurophysiol 82, 3316-3326
   Abstract »    Full Text »    PDF »
ATP P2× Receptors and Sensory Synaptic Transmission Between Primary Afferent Fibers and Spinal Dorsal Horn Neurons in Rats.
P. Li, A. A. Calejesan, and M. Zhuo (1998)
J Neurophysiol 80, 3356-3360
   Abstract »    Full Text »    PDF »
Direct Comparison of Heat-Evoked Activity of Nociceptive Neurons in the Dorsal Horn With the Hindpaw Withdrawal Reflex in the Rat.
M. M. Morgan (1998)
J Neurophysiol 79, 174-180
   Abstract »    Full Text »    PDF »
Phosphorylation of Transcription Factor CREB in Rat Spinal Cord after Formalin-Induced Hyperalgesia: Relationship to c-fos Induction.
R.-R. Ji and F. Rupp (1997)
J. Neurosci. 17, 1776-1785
   Abstract »    Full Text »    PDF »
The thermal grill illusion: unmasking the burn of cold pain.
A. Craig and M. Bushnell (1994)
Science 265, 252-255
   Abstract »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)