Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 10 October 1986:
Vol. 234. no. 4773, pp. 196 - 197
DOI: 10.1126/science.3018932
Prev | Table of Contents | Next

Articles

Science, Vol 234, Issue 4773, 196-197
Copyright © 1986 by American Association for the Advancement of Science

articles

Physiological variation in alpha-adrenoceptor-mediated arterial sensitivity: relation to agonist affinity

JA Bevan, MA Oriowo, and RD Bevan

Vascular smooth muscle from different arteries of the rabbit varies in sensitivity to norepinephrine, even when factors known to contribute to this variation are excluded. Sensitivity to norepinephrine mediated through the alpha-adrenoceptor is linearly related to the agonist dissociation constant, but is not significantly related to receptor reserve. These results suggest that agonist affinity is the primary determinant of sensitivity to norepinephrine, at least in these arteries, and that this is a locally regulated characteristic which may account for regional sensitivity changes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
{alpha}1-Adrenoceptor-dependent vascular hypertrophy and remodeling in murine hypoxic pulmonary hypertension.
J. E. Faber, C. L. Szymeczek, S. Cotecchia, S. A. Thomas, A. Tanoue, G. Tsujimoto, and H. Zhang (2007)
Am J Physiol Heart Circ Physiol 292, H2316-H2323
   Abstract »    Full Text »    PDF »
Enhanced {alpha}1-adrenergic trophic activity in pulmonary artery of hypoxic pulmonary hypertensive rats.
J. E. Faber, C. L. Szymeczek, S. S. Salvi, and H. Zhang (2006)
Am J Physiol Heart Circ Physiol 291, H2272-H2281
   Abstract »    Full Text »    PDF »
{alpha}1-Adrenergic Hypothesis for Pulmonary Hypertension.
S. S. Salvi (1999)
Chest 115, 1708-1719
   Abstract »    Full Text »    PDF »
Weakness of Sympathetic Neural Control of Human Pial Compared With Superficial Temporal Arteries Reflects Low Innervation Density and Poor Sympathetic Responsiveness • Editorial Comment.
R. D. Bevan, J. Dodge, P. Nichols, P. L. Penar, C. L. Walters, T. Wellman, J. A. Bevan, and T. J-F. Lee (1998)
Stroke 29, 212-221
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)