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Science 19 September 1986:
Vol. 233. no. 4770, pp. 1308 - 1311
DOI: 10.1126/science.3749878
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Articles
Science, Vol 233, Issue 4770, 1308-1311
Copyright © 1986 by American Association for the Advancement of Science
Effects of alcohol on the generation and migration of cerebral cortical neurons
MW Miller
Prenatal exposure to alcohol produces many developmental defects of the central nervous system, such as microcephaly, mental retardation, motor dysfunction, and cognitive deficiencies. Therefore, the generation of neurons in the cerebral cortex was examined in the offspring of female rats fed a diet containing ethanol. Prenatal exposure to ethanol delayed and extended the period during which cortical neurons were generated, reduced the number of neurons in the nature cortex with the same time of origin, and altered the distribution of neurons generated on a particular day. Thus, the proliferation and migration of cortical neurons are profoundly affected by in utero exposure to ethanol.
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