Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Eppendorf & Science Prize for Neurobiology

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 19 September 1986:
Vol. 233. no. 4770, pp. 1286 - 1293
DOI: 10.1126/science.3018924
Prev | Table of Contents | Next

Articles

Science, Vol 233, Issue 4770, 1286-1293
Copyright © 1986 by American Association for the Advancement of Science

articles

The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating

TJ Smith, MJ Kremer, M Luo, G Vriend, E Arnold, G Kamer, MG Rossmann, MA McKinlay, GD Diana, and MJ Otto

WIN 51711 and WIN 52084 are structurally related, antiviral compounds that inhibit the replication of rhino (common cold) viruses and related picornaviruses. They prevent the pH-mediated uncoating of the viral RNA. The compounds consist of a 3-methylisoxazole group that inserts itself into the hydrophobic interior of the VP1 beta-barrel, a connecting seven-membered aliphatic chain, and a 4-oxazolinylphenoxy group (OP) that covers the entrance to an ion channel in the floor of the "canyon." Viral disassembly may be inhibited by preventing the collapse of the VP1 hydrophobic pocket or by blocking the flow of ions into the virus interior.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pocket Factors Are Unlikely To Play a Major Role in the Life Cycle of Human Rhinovirus.
U. Katpally and T. J. Smith (2007)
J. Virol. 81, 6307-6315
   Abstract »    Full Text »    PDF »
Inhibition of HIV-1 Maturation via Drug Association with the Viral Gag Protein in Immature HIV-1 Particles.
J. Zhou, L. Huang, D. L. Hachey, C. H. Chen, and C. Aiken (2005)
J. Biol. Chem. 280, 42149-42155
   Abstract »    Full Text »    PDF »
Capsid structure and dynamics of a human rhinovirus probed by hydrogen exchange mass spectrometry.
L. Wang and D. L. Smith (2005)
Protein Sci. 14, 1661-1672
   Abstract »    Full Text »    PDF »
From the Cover: Dissociation of an antiviral compound from the internal pocket of human rhinovirus 14 capsid.
Y. Li, Z. Zhou, and C. B. Post (2005)
PNAS 102, 7529-7534
   Abstract »    Full Text »    PDF »
Structural and Virological Studies of the Stages of Virus Replication That Are Affected by Antirhinovirus Compounds.
Y. Zhang, A. A. Simpson, R. M. Ledford, C. M. Bator, S. Chakravarty, G. A. Skochko, T. M. Demenczuk, A. Watanyar, D. C. Pevear, and M. G. Rossmann (2004)
J. Virol. 78, 11061-11069
   Abstract »    Full Text »    PDF »
Discrimination among Rhinovirus Serotypes for a Variant ICAM-1 Receptor Molecule.
C. Xiao, T. J. Tuthill, C. M. Bator Kelly, L. J. Challinor, P. R. Chipman, R. A. Killington, D. J. Rowlands, A. Craig, and M. G. Rossmann (2004)
J. Virol. 78, 10034-10044
   Abstract »    Full Text »    PDF »
Mechanism of Action at the Molecular Level of the Antiviral Drug 3(2H)-Isoflavene against Type 2 Poliovirus.
A. L. Salvati, A. De Dominicis, S. Tait, A. Canitano, A. Lahm, and L. Fiore (2004)
Antimicrob. Agents Chemother. 48, 2233-2243
   Abstract »    Full Text »    PDF »
The dimerization domain of the HIV-1 capsid protein binds a capsid protein-derived peptide: A biophysical characterization.
M. T. Garzon, M. C. Lidon-Moya, F. N. Barrera, A. Prieto, J. Gomez, M. G. Mateu, and J. L. Neira (2004)
Protein Sci. 13, 1512-1523
   Abstract »    Full Text »    PDF »
VP1 Sequencing of All Human Rhinovirus Serotypes: Insights into Genus Phylogeny and Susceptibility to Antiviral Capsid-Binding Compounds.
R. M. Ledford, N. R. Patel, T. M. Demenczuk, A. Watanyar, T. Herbertz, M. S. Collett, and D. C. Pevear (2004)
J. Virol. 78, 3663-3674
   Abstract »    Full Text »    PDF »
Structure of Swine Vesicular Disease Virus: Mapping of Changes Occurring during Adaptation of Human Coxsackie B5 Virus To Infect Swine.
N. Verdaguer, M. A. Jimenez-Clavero, I. Fita, and V. Ley (2003)
J. Virol. 77, 9780-9789
   Abstract »    Full Text »    PDF »
A Cellular Receptor of Human Rhinovirus Type 2, the Very-Low-Density Lipoprotein Receptor, Binds to Two Neighboring Proteins of the Viral Capsid.
E. Neumann, R. Moser, L. Snyers, D. Blaas, and E. A. Hewat (2003)
J. Virol. 77, 8504-8511
   Abstract »    Full Text »    PDF »
A ligand-binding pocket in the dengue virus envelope glycoprotein.
Y. Modis, S. Ogata, D. Clements, and S. C. Harrison (2003)
PNAS 100, 6986-6991
   Abstract »    Full Text »    PDF »
Human Rhinovirus Type 16: Mutant V1210A Requires Capsid-Binding Drug for Assembly of Pentamers To Form Virions during Morphogenesis.
W.-M. Lee and W. Wang (2003)
J. Virol. 77, 6235-6244
   Abstract »    Full Text »    PDF »
Complexes of Poliovirus Serotypes with Their Common Cellular Receptor, CD155.
Y. He, S. Mueller, P. R. Chipman, C. M. Bator, X. Peng, V. D. Bowman, S. Mukhopadhyay, E. Wimmer, R. J. Kuhn, and M. G. Rossmann (2003)
J. Virol. 77, 4827-4835
   Abstract »    Full Text »    PDF »
Picornavirus uncoating.
M S Smyth and J H Martin (2002)
Mol. Pathol. 55, 214-219
   Abstract »    Full Text »    PDF »
Kinetic Analysis of the Effect of Poliovirus Receptor on Viral Uncoating: the Receptor as a Catalyst.
S. K. Tsang, B. M. McDermott, V. R. Racaniello, and J. M. Hogle (2001)
J. Virol. 75, 4984-4989
   Abstract »    Full Text »
An Antiviral Compound That Blocks Structural Transitions of Poliovirus Prevents Receptor Binding at Low Temperatures.
A. W. Dove and V. R. Racaniello (2000)
J. Virol. 74, 3929-3931
   Abstract »    Full Text »
Mutation of Predicted Virion Pit Residues Alters Binding of Theiler's Murine Encephalomyelitis Virus to BHK-21 Cells.
S. Hertzler, M. Luo, and H. L. Lipton (2000)
J. Virol. 74, 1994-2004
   Abstract »    Full Text »
Analysis of three structurally related antiviral compounds in complex with human rhinovirus 16.
A. T. Hadfield, G. D. Diana, and M. G. Rossmann (1999)
PNAS 96, 14730-14735
   Abstract »    Full Text »    PDF »
Activity of Pleconaril against Enteroviruses.
D. C. Pevear, T. M. Tull, M. E. Seipel, and J. M. Groarke (1999)
Antimicrob. Agents Chemother. 43, 2109-2115
   Abstract »    Full Text »
Antiviral agent blocks breathing of the common cold virus.
J. K. Lewis, B. Bothner, T. J. Smith, and G. Siuzdak (1998)
PNAS 95, 6774-6778
   Abstract »    Full Text »    PDF »
WIN 52035-Dependent Human Rhinovirus 16: Assembly Deficiency Caused by Mutations near the Canyon Surface.
W. Wang, W.-M. Lee, A. G. Mosser, and R. R. Rueckert (1998)
J. Virol. 72, 1210-1218
   Abstract »    Full Text »    PDF »
Structure-Based Strategies for Drug Design and Discovery.
I. D. Kuntz (1992)
Science 257, 1078-1082
   Abstract »    PDF »
The three-dimensional structure of canine parvovirus and its functional implications.
J Tsao, M. Chapman, M Agbandje, W Keller, K Smith, H Wu, M Luo, T. Smith, M. Rossmann, R. Compans, et al. (1991)
Science 251, 1456-1464
   Abstract »    PDF »
Molecular targets for AIDS therapy.
H Mitsuya, R Yarchoan, and S Broder (1990)
Science 249, 1533-1544
   Abstract »    PDF »
Computer-aided molecular design.
J. McCammon (1987)
Science 238, 486-491
   Abstract »    PDF »
New Opportunities in Synchrotron X-ray Crystallography.
C. T. PREWITT, P. COPPENS, J. C. PHILLIPS, and L. W. FINGER (1987)
Science 238, 312-319
   Abstract »    PDF »
The atomic structure of Mengo virus at 3.0 A resolution.
M Luo, G Vriend, G Kamer, I Minor, E Arnold, M. Rossmann, U Boege, D. Scraba, G. Duke, and A. Palmenberg (1987)
Science 235, 182-191
   Abstract »    PDF »
Viral capsid mobility: A dynamic conduit for inactivation.
K. Broo, J. Wei, D. Marshall, F. Brown, T. J. Smith, J. E. Johnson, A. Schneemann, and G. Siuzdak (2001)
PNAS 98, 2274-2277
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products