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Science 12 September 1986:
Vol. 233. no. 4769, pp. 1190 - 1192
DOI: 10.1126/science.2426782
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Articles

Science, Vol 233, Issue 4769, 1190-1192
Copyright © 1986 by American Association for the Advancement of Science

articles

Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes

AA Demetriou, JF Whiting, D Feldman, SM Levenson, NR Chowdhury, AD Moscioni, M Kram, and Chowdhury JR

Isolated hepatocytes, harvested from normal rat livers by portal vein collagenase perfusion, can be attached to collagen-coated dextran microcarriers and transplanted by intraperitoneal injection into rats. Survival and function of the transplanted hepatocytes have been demonstrated in mutant rats lacking bilirubin-uridine diphosphate glucuronosyltransferase activity (Gunn strain) and rats with inherited lack of plasma albumin (Nagase analbuminemia rat strain). This simple technique promises to be useful in the treatment of acute liver failure in humans.


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