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Science 5 September 1986:
Vol. 233. no. 4768, pp. 1084 - 1086
DOI: 10.1126/science.3016902
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Articles

Science, Vol 233, Issue 4768, 1084-1086
Copyright © 1986 by American Association for the Advancement of Science

articles

Direct polyclonal activation of human B lymphocytes by the acquired immune deficiency syndrome virus

SM Schnittman, HC Lane, SE Higgins, T Folks, and AS Fauci

When B lymphocytes from normal human peripheral blood were incubated for 1 hour with the retrovirus that causes the acquired immune deficiency syndrome (AIDS), the B cells showed marked proliferation and differentiation. Proliferative responses to the virus peaked on day 4 and appeared to be independent of accessory cells. This finding was repeated with three separate viral isolates, one of which was from a patient from Zaire. The magnitude of the observed responses was comparable to that seen with standard polyclonal B-cell activators. This phenomenon may be at least partially responsible for the polyclonal B-cell activation seen in patients with AIDS.


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