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Science 29 August 1986:
Vol. 233. no. 4767, pp. 948 - 952
DOI: 10.1126/science.3016897
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Articles

Science, Vol 233, Issue 4767, 948-952
Copyright © 1986 by American Association for the Advancement of Science

articles

Long-range electron transfer in heme proteins

SL Mayo, WR Ellis Jr, RJ Crutchley, and HB Gray

Kinetic experiments have conclusively shown that electron transfer can take place over large distances (greater than 10 angstroms) through protein interiors. Current research focuses on the elucidation of the factors that determine the rates of long-range electron-transfer reactions in modified proteins and protein complexes. Factors receiving experimental and theoretical attention include the donor-acceptor distance, changes in geometry of the donor and acceptor upon electron transfer, and the thermodynamic driving force. Recent experimental work on heme proteins indicates that the electron-transfer rate falls off exponentially with donor-acceptor distance at long range. The rate is greatly enhanced in proteins in which the structural changes accompanying electron transfer are very small.


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