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Science 29 August 1986:
Vol. 233. no. 4767, pp. 941 - 947
DOI: 10.1126/science.3738519
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Articles

Science, Vol 233, Issue 4767, 941-947
Copyright © 1986 by American Association for the Advancement of Science

articles

The neurobiology of learning and memory

RF Thompson

Study of the neurobiology of learning and memory is in a most exciting phase. Behavioral studies in animals are characterizing the categories and properties of learning and memory; essential memory trace circuits in the brain are being defined and localized in mammalian models; work on human memory and the brain is identifying neuronal systems involved in memory; the neuronal, neurochemical, molecular, and biophysical substrates of memory are beginning to be understood in both invertebrate and vertebrate systems; and theoretical and mathematical analysis of basic associative learning and of neuronal networks in proceeding apace. Likely applications of this new understanding of the neural bases of learning and memory range from education to the treatment of learning disabilities to the design of new artificial intelligence systems.


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Temporal specificity of long-term depression in parallel fiber--Purkinje synapses in rat cerebellar slice..
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S. Kim, K Ugurbil, and P. Strick (1994)
Science 265, 949-951
   Abstract »    PDF »
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A Pascual-Leone, J Grafman, and M Hallett (1994)
Science 263, 1287-1289
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Sensorimotor skill learning in amnesia: additional evidence for the neural basis of nondeclarative memory..
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   Abstract »    PDF »
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DeLiang Wang (1993)
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   Abstract »    PDF »
Localization of a memory trace in the mammalian brain.
D. Krupa, J. Thompson, and R. Thompson (1993)
Science 260, 989-991
   Abstract »    PDF »
Age-Related Regional Differences in Cerebellar Vermis Observed In Vivo.
N. Raz, I. J. Torres, W. D. Spencer, K. White, and J. D. Acker (1992)
Arch Neurol 49, 412-416
   Abstract »    PDF »
Participation of postsynaptic PKC in cerebellar long-term depression in culture.
D. Linden and J. Connor (1991)
Science 254, 1656-1659
   Abstract »    PDF »
The medial temporal lobe memory system.
L. Squire and S Zola-Morgan (1991)
Science 253, 1380-1386
   Abstract »    PDF »
Priming and human memory systems.
E Tulving and D. Schacter (1990)
Science 247, 301-306
   Abstract »    PDF »
Reduced Cerebellar Hemisphere Size and Its Relationship to Vermal Hypoplasia in Autism.
J. W. Murakami, E. Courchesne, G. A. Press, R. Yeung-Courchesne, and J. R. Hesselink (1989)
Arch Neurol 46, 689-694
   Abstract »    PDF »
Learning Disabilities: A Neurobiological Perspective in Humans.
K. A. Bonnet (1989)
Remedial and Special Education 10, 8-19
   Abstract »    PDF »
The neural basis for learning of simple motor skills.
S. Lisberger (1988)
Science 242, 728-735
   Abstract »    PDF »
Computational neuroscience.
T. Sejnowski, C Koch, and P. Churchland (1988)
Science 241, 1299-1306
   Abstract »    PDF »
The cerebellum and memory storage.
J. Bloedel (1987)
Science 238, 1728-1730
   PDF »
Response: The Cerebellum and Memory Storage.
R. F. THOMPSON (1987)
Science 238, 1729-1730
   PDF »
Biochemistry of information storage in the nervous system.
I. Black, J. Adler, C. Dreyfus, W. Friedman, E. LaGamma, and A. Roach (1987)
Science 236, 1263-1268
   Abstract »    PDF »
A Systematic Method for Clinical Description and Classification of Personality Variants: A Proposal.
C. R. Cloninger (1987)
Arch Gen Psychiatry 44, 573-588
   Abstract »    PDF »
Neurogenetic adaptive mechanisms in alcoholism.
C. Cloninger (1987)
Science 236, 410-416
   Abstract »    PDF »
Galantamine: Effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning.
D. S. Woodruff-Pak, R. W. Vogel III, and G. L. Wenk (2001)
PNAS 98, 2089-2094
   Abstract »    Full Text »    PDF »
Cerebellar cortical inhibition and classical eyeblink conditioning.
S. Bao, L. Chen, J. J. Kim, and R. F. Thompson (2002)
PNAS 99, 1592-1597
   Abstract »    Full Text »    PDF »
Behavior-Dependent States of the Hippocampal Network Affect Functional Clustering of Neurons.
H. Hirase, X. Leinekugel, J. Csicsvari, A. Czurko, and G. Buzsaki (2001)
J. Neurosci. 21, RC145
   Abstract »    Full Text »    PDF »


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