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Science 15 August 1986:
Vol. 233. no. 4765, pp. 774 - 776
DOI: 10.1126/science.3016896
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Articles

Science, Vol 233, Issue 4765, 774-776
Copyright © 1986 by American Association for the Advancement of Science

articles

Psychotomimesis mediated by kappa opiate receptors

A Pfeiffer, V Brantl, A Herz, and HM Emrich

The kappa opioid agonists are analgesics that seem to be free of undesired morphine-like effects. Their dysphoric actions observed with the kappa agonist cyclazocine are thought to be mediated by an action at sigma-phencyclidine receptors. The benzomorphan kappa agonist MR 2033 is inactive at sigma-phencyclidine receptors. In male subjects, the opiate-active (-)-isomer, but not the (+)-isomer, elicited dose-dependent dysphoric and psychotomimetic effects that were antagonized by naloxone. Thus, kappa opiate receptors seem to mediate psychotomimetic effects. In view of the euphorigenic properties of mu agonists, our results imply the existence of opposed opioid systems affecting emotional and perceptual experiences.


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