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Science 8 August 1986:
Vol. 233. no. 4764, pp. 640 - 645
DOI: 10.1126/science.3726553
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Articles

Science, Vol 233, Issue 4764, 640-645
Copyright © 1986 by American Association for the Advancement of Science

articles

The use of NMR spectroscopy for the understanding of disease

GK Radda

Nuclear magnetic resonance spectroscopy can now be used to investigate the biochemical energetics of human tissues and organs noninvasively. The method already has increased our understanding of some muscle diseases, has provided information from muscle metabolism about whole-body functions, control, and hormonal status, has helped in the elucidation of hitherto unrecognized causes of disease, and yielded new ideas about the control of bioenergetics in vivo. Studies on the biochemistry of human brain, liver, heart, and kidney are just beginning. Further investigations of well-selected patients are likely to bring biochemistry and clinical practice closer together.


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