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Science 1 August 1986:
Vol. 233. no. 4763, pp. 532 - 534
DOI: 10.1126/science.3487831

Articles

Science, Vol 233, Issue 4763, 532-534
Copyright © 1986 by American Association for the Advancement of Science


articles

Transforming growth factor-beta: biological function and chemical structure

MB Sporn, AB Roberts, LM Wakefield, and RK Assoian

Transforming growth factor-beta (TGF-beta) is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGF-beta and essentially all of them have specific receptors for this peptide. TGF-beta regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. Its marked ability to enhance formation of connective tissue in vivo suggests several therapeutic applications.


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Signal Transduction through Interleukin-5 Receptors.
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Reversible inhibition of mammary gland growth by transforming growth factor-beta.
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