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Science 1 August 1986: Vol. 233. no. 4763, pp. 532 - 534 DOI: 10.1126/science.3487831
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Articles
Science, Vol 233, Issue 4763, 532-534
Copyright © 1986 by American Association for the Advancement of Science
Transforming growth factor-beta: biological function and chemical structure
MB Sporn,
AB Roberts,
LM Wakefield,
and
RK Assoian
Transforming growth factor-beta (TGF-beta) is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGF-beta and essentially all of them have specific receptors for this peptide. TGF-beta regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. Its marked ability to enhance formation of connective tissue in vivo suggests several therapeutic applications.
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