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Science 25 July 1986:
Vol. 233. no. 4762, pp. 458 - 460
DOI: 10.1126/science.3726540
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Articles

Science, Vol 233, Issue 4762, 458-460
Copyright © 1986 by American Association for the Advancement of Science

articles

Induction of the c-fos oncogene by thyrotropic hormone in rat thyroid cells in culture

G Colletta, AM Cirafici, and G Vecchio

Rat thyroid cells in culture, rendered quiescent by hormone deprivation, can be stimulated to undergo DNA synthesis in the absence of serum by the addition of purified thyrotropin. The primary effect in response to thyrotropin action in thyroid cells is the induction of the c-fos oncogene, followed by c-myc expression. This suggests that thyrotropin acts as a competence growth factor.


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