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Science 18 July 1986:
Vol. 233. no. 4761, pp. 347 - 351
DOI: 10.1126/science.3014652
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Articles

Science, Vol 233, Issue 4761, 347-351
Copyright © 1986 by American Association for the Advancement of Science

articles

Studies of the human c-myb gene and its product in human acute leukemias

DJ Slamon, TC Boone, DC Murdock, DE Keith, MF Press, RA Larson, and LM Souza

The myb gene is the transforming oncogene of the avian myeloblastosis virus (AMV); its normal cellular homolog, c-myb, is conserved across a broad span of evolution. In humans, c-myb is expressed in malignant hematopoietic cell lines and in primary hematopoietic tumors. Partial complementary DNA clones were generated from blast cells of patients with acute myelogenous leukemia. The sequences of the clones were compared to the c-myb of other species, as well as the v-myb of AMV. In addition, the carboxyl terminal region of human c-myb was placed in an expression vector to obtain protein for the generation of antiserum, which was used to identify the human c-myb gene product. Like v-myb, this protein was found within the nucleus of leukemic cells where it was associated with the nuclear matrix. These studies provide further evidence that c-myb might be involved in human leukemia.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration.
M. Eijgelsheim, A. L.H.J. Aarnoudse, F. Rivadeneira, J. A. Kors, J. C. M. Witteman, A. Hofman, C. M. van Duijn, A. G. Uitterlinden, and B. H.C. Stricker (2009)
Hum. Mol. Genet. 18, 347-357
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c-Myb Is an Evolutionary Conserved miR-150 Target and miR-150/c-Myb Interaction Is Important for Embryonic Development.
Y.-C. Lin, M.-W. Kuo, J. Yu, H.-H. Kuo, R.-J. Lin, W.-L. Lo, and A. L. Yu (2008)
Mol. Biol. Evol. 25, 2189-2198
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A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity.
S. L. Palumbo, R. M. Memmott, D. J. Uribe, Y. Krotova-Khan, L. H. Hurley, and S. W. Ebbinghaus (2008)
Nucleic Acids Res. 36, 1755-1769
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The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children.
E. Clappier, W. Cuccuini, A. Kalota, A. Crinquette, J.-M. Cayuela, W. A. Dik, A. W. Langerak, B. Montpellier, B. Nadel, P. Walrafen, et al. (2007)
Blood 110, 1251-1261
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More on Myb in myelofibrosis: molecular analyses of MYB and EP300 in 55 patients with myeloproliferative disorders.
D. P. Steensma, A. Pardanani, W. S. Stevenson, R. Hoyt, H. Kiu, A. P. Grigg, J. Szer, S. Juneja, D. J. Hilton, W. S. Alexander, et al. (2006)
Blood 107, 1733-1735
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Enhanced Proliferative Potential of Hematopoietic Cells Expressing Degradation-resistant c-Myb Mutants.
F. Corradini, V. Cesi, V. Bartella, E. Pani, R. Bussolari, O. Candini, and B. Calabretta (2005)
J. Biol. Chem. 280, 30254-30262
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The Arabidopsis Transcription Factor MYB12 Is a Flavonol-Specific Regulator of Phenylpropanoid Biosynthesis.
F. Mehrtens, H. Kranz, P. Bednarek, and B. Weisshaar (2005)
Plant Physiology 138, 1083-1096
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Disruption of Rb/E2F Pathway Results in Increased Cyclooxygenase-2 Expression and Activity in Prostate Epithelial Cells.
J. N. Davis, M. T. McCabe, S. W. Hayward, J. M. Park, and M. L. Day (2005)
Cancer Res. 65, 3633-3642
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Distinct Cellular Factors Regulate the c-myb Promoter through Its E2F Element.
M. R. Campanero, M. Armstrong, and E. Flemington (1999)
Mol. Cell. Biol. 19, 8442-8450
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The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct-1.
M. W. Wong, R. W. Henry, B. Ma, R. Kobayashi, N. Klages, P. Matthias, M. Strubin, and N. Hernandez (1998)
Mol. Cell. Biol. 18, 368-377
   Abstract »    Full Text »
Differences between Plant and Animal Myb Domains Are Fundamental for DNA Binding Activity, and Chimeric Myb Domains Have Novel DNA Binding Specificities.
C. E. Williams and E. Grotewold (1997)
J. Biol. Chem. 272, 563-571
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Myb and Ets Proteins Cooperate to Transactivate an Early Myeloid Gene.
L. H. Shapiro and L. H. Shapiro (1995)
J. Biol. Chem. 270, 8763-8771
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flbD encodes a Myb-like DNA-binding protein that coordinates initiation of Aspergillus nidulans conidiophore development..
J Wieser and T H Adams (1995)
Genes & Dev. 9, 491-502
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Activation of transcription by v-myb: evidence for two different mechanisms..
K H Klempnauer, H Arnold, and H Biedenkapp (1989)
Genes & Dev. 3, 1582-1589
   Abstract »    PDF »
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer.
D. Slamon, W Godolphin, L. Jones, J. Holt, S. Wong, D. Keith, W. Levin, S. Stuart, J Udove, A Ullrich, et al. (1989)
Science 244, 707-712
   Abstract »    PDF »
A c-myb antisense oligodeoxynucleotide inhibits normal human hematopoiesis in vitro.
A. Gewirtz and B Calabretta (1988)
Science 242, 1303-1306
   Abstract »    PDF »


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