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Science 27 June 1986:
Vol. 232. no. 4758, pp. 1638 - 1640
DOI: 10.1126/science.3715470
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Articles

Science, Vol 232, Issue 4758, 1638-1640
Copyright © 1986 by American Association for the Advancement of Science

articles

Suppression of neurite elongation and growth cone motility by electrical activity

CS Cohan and SB Kater

Electrical activity may regulate a number of neuronal functions in addition to its role in transmitting signals along nerve cells. The hypothesis that electrical activity affects neurite elongation in sprouting neurons was tested by stimulating individual snail neurons isolated in cell culture. The findings demonstrated that growth cone advance, and thus neurite elongation, is reversibly stopped during periods when action potentials are experimentally evoked. A decrease in filopodial number and growth cone area was also observed. Thus, action potentials can mediate the cessation of neurite outgrowth and thereby may influence structure and connectivity within the nervous system.


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