Science 27 June 1986: Vol. 232. no. 4758, pp. 1629 - 1632 DOI: 10.1126/science.3487117

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Articles

A Novel Sartan Derivative With Very Low Angiotensin II Type 1 Receptor Affinity Protects the Kidney in Type 2 Diabetic Rats.

Y. Izuhara, T. Sada, H. Yanagisawa, H. Koike, S. Ohtomo, T. Dan, S. Ito, M. Nangaku, C. van Ypersele de Strihou, and T. Miyata (2008)
Arterioscler. Thromb. Vasc. Biol. 28, 1767-1773
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Advanced Glycation End Products in Progression and Complications of Diabetes.

S.-Y. Goh and M. E. Cooper (2008)
J. Clin. Endocrinol. Metab. 93, 1143-1152
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A changing paradigm for prevention of cardiovascular disease: emergence of the metabolic syndrome as a multiplex risk factor.

S. M. Grundy (2008)
Eur. Heart J. Suppl. 10, B16-B23
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A novel class of advanced glycation inhibitors ameliorates renal and cardiovascular damage in experimental rat models.

Y. Izuhara, M. Nangaku, S. Takizawa, S. Takahashi, J. Shao, H. Oishi, H. Kobayashi, C. van Ypersele de Strihou, and T. Miyata (2008)
Nephrol. Dial. Transplant. 23, 497-509
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for in Vivo Scavenging by Aminoguanidine of Formaldehyde Produced via Semicarbazide-Sensitive Amine Oxidase-Mediated Deamination.

M. Kazachkov, K. Chen, S. Babiy, and P. H. Yu (2007)
J. Pharmacol. Exp. Ther. 322, 1201-1207
 |  Abstract »  |  Full Text »  |  PDF »

Association between glycosylated hemoglobin, left ventricular mass and aortic function in nondiabetic individuals with insulin resistance.

D. A Stakos, D. P Schuster, E. A Sparks, S. B. Meis, C. F Wooley, K. Osei, and H. Boudoulas (2007)
Eur. J. Endocrinol. 157, 63-68
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Methylglyoxal Inhibits the Binding Step of Collagen Phagocytosis.

S. A. C. Chong, W. Lee, P. D. Arora, C. Laschinger, E. W. K. Young, C. A. Simmons, M. Manolson, J. Sodek, and C. A. McCulloch (2007)
J. Biol. Chem. 282, 8510-8520
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Combination Therapy with the Advanced Glycation End Product Cross-Link Breaker, Alagebrium, and Angiotensin Converting Enzyme Inhibitors in Diabetes: Synergy or Redundancy?.

M. T. Coughlan, V. Thallas-Bonke, J. Pete, D. M. Long, A. Gasser, D. C. K. Tong, M. Arnstein, S. R. Thorpe, M. E. Cooper, and J. M. Forbes (2007)
Endocrinology 148, 886-895
 |  Abstract »  |  Full Text »  |  PDF »

Diabetes and Advanced Glycoxidation End Products..

A. G. Huebschmann, J. G. Regensteiner, H. Vlassara, and J. E.B. Reusch (2006)
Diabetes Care 29, 1420-1432
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Advanced Glycation End Products Inhibit Tubulogenesis and Migration of Kidney Epithelial Cells in an Ezrin-Dependent Manner.

M. A Gallicchio, E. A. McRobert, A. Tikoo, M. E. Cooper, and L. A. Bach (2006)
J. Am. Soc. Nephrol. 17, 414-421
 |  Abstract »  |  Full Text »  |  PDF »

Advanced glycation end products and the kidney.

J. M. Bohlender, S. Franke, G. Stein, and G. Wolf (2005)
Am J Physiol Renal Physiol 289, F645-F659
 |  Abstract »  |  Full Text »  |  PDF »

Glucosepane Is a Major Protein Cross-link of the Senescent Human Extracellular Matrix: RELATIONSHIP WITH DIABETES.

D. R. Sell, K. M. Biemel, O. Reihl, M. O. Lederer, C. M. Strauch, and V. M. Monnier (2005)
J. Biol. Chem. 280, 12310-12315
 |  Abstract »  |  Full Text »  |  PDF »

Aminoguanidine Prevents Fructose-Induced Arterial Stiffening in Wistar Rats: Aortic Impedance Analysis.

Y.-T. Lin, Y.-Z. Tseng, and K.-C. Chang (2004)
Experimental Biology and Medicine 229, 1038-1045
 |  Abstract »  |  Full Text »  |  PDF »

Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes.

G. Basta, A. M. Schmidt, and R. De Caterina (2004)
Cardiovasc Res 63, 582-592
 |  Abstract »  |  Full Text »  |  PDF »

Advanced Glycation End Product Interventions Reduce Diabetes-Accelerated Atherosclerosis.

J. M. Forbes, L. T. L. Yee, V. Thallas, M. Lassila, R. Candido, K. A. Jandeleit-Dahm, M. C. Thomas, W. C. Burns, E. K. Deemer, S. R. Thorpe, et al. (2004)
Diabetes 53, 1813-1823
 |  Abstract »  |  Full Text »  |  PDF »

Diabetic Retinopathy.

R. N. Frank (2004)
N. Engl. J. Med. 350, 48-58
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Modification of Proteins In Vitro by Physiological Levels of Glucose: PYRIDOXAMINE INHIBITS CONVERSION OF AMADORI INTERMEDIATE TO ADVANCED GLYCATION END-PRODUCTS THROUGH BINDING OF REDOX METAL IONS.

P. A. Voziyan, R. G. Khalifah, C. Thibaudeau, A. Yildiz, J. Jacob, A. S. Serianni, and B. G. Hudson (2003)
J. Biol. Chem. 278, 46616-46624
 |  Abstract »  |  Full Text »  |  PDF »

The Amino-terminal Domains of the Ezrin, Radixin, and Moesin (ERM) Proteins Bind Advanced Glycation End Products, an Interaction That May Play a Role in the Development of Diabetic Complications.

E. A. McRobert, M. Gallicchio, G. Jerums, M. E. Cooper, and L. A. Bach (2003)
J. Biol. Chem. 278, 25783-25789
 |  Abstract »  |  Full Text »  |  PDF »

Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy.

K. L. Herrmann, A. D. McCulloch, and J. H. Omens (2003)
Am J Physiol Heart Circ Physiol 284, H1277-H1284
 |  Abstract »  |  Full Text »  |  PDF »

Collagen cross-linking: new dimension to cardiac remodeling.

S. K.G Koshy, H. K Reddy, and H. H Shukla (2003)
Cardiovasc Res 57, 594-598
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Cross-linking influences the impact of quantitative changes in myocardial collagen on cardiac stiffness and remodelling in hypertension in rats.

D. Badenhorst, M. Maseko, O. J Tsotetsi, A. Naidoo, R. Brooksbank, G. R Norton, and A. J Woodiwiss (2003)
Cardiovasc Res 57, 632-641
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of cardiovascular complications in diabetes and potential new pharmacological therapies.

Z. He, C. Rask-Madsen, and G.L. King (2003)
Eur. Heart J. Suppl. 5, B51-B57
 |  Abstract »  |  PDF »

Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications.

M. J. Sheetz and G. L. King (2002)
JAMA 288, 2579-2588
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Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy.

H. Vlassara, W. Cai, J. Crandall, T. Goldberg, R. Oberstein, V. Dardaine, M. Peppa, and E. J. Rayfield (2002)
PNAS 99, 15596-15601
 |  Abstract »  |  Full Text »  |  PDF »

Glycation by Ascorbic Acid Causes Loss of Activity of Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase and Its Increased Susceptibility to Proteases.

Y. Yamauchi, Y. Ejiri, and K. Tanaka (2002)
Plant Cell Physiol. 43, 1334-1341
 |  Abstract »  |  Full Text »  |  PDF »

Reduction of the Accumulation of Advanced Glycation End Products by ACE Inhibition in Experimental Diabetic Nephropathy.

J. M. Forbes, M. E. Cooper, V. Thallas, W. C. Burns, M. C. Thomas, G. C. Brammar, F. Lee, S. L. Grant, L. A. Burrell, G. Jerums, et al. (2002)
Diabetes 51, 3274-3282
 |  Abstract »  |  Full Text »  |  PDF »

Angiotensin II Receptor Antagonists and Angiotensin-Converting Enzyme Inhibitors Lower In Vitro the Formation of Advanced Glycation End Products: Biochemical Mechanisms.

T. Miyata, C. van Ypersele de Strihou, Y. Ueda, K. Ichimori, R. Inagi, H. Onogi, N. Ishikawa, M. Nangaku, and K. Kurokawa (2002)
J. Am. Soc. Nephrol. 13, 2478-2487
 |  Abstract »  |  Full Text »  |  PDF »

Peroxynitrite Induces Formation of N{varepsilon}-(Carboxymethyl)Lysine by the Cleavage of Amadori Product and Generation of Glucosone and Glyoxal From Glucose: Novel Pathways for Protein Modification by Peroxynitrite.

R. Nagai, Y. Unno, M. C. Hayashi, S. Masuda, F. Hayase, N. Kinae, and S. Horiuchi (2002)
Diabetes 51, 2833-2839
 |  Abstract »  |  Full Text »  |  PDF »

Myocardial stiffness is determined by ventricular fibrosis, but not by compensatory or excessive hypertrophy in hypertensive heart.

K. Yamamoto, T. Masuyama, Y. Sakata, N. Nishikawa, T. Mano, J. Yoshida, T. Miwa, M. Sugawara, Y. Yamaguchi, T. Ookawara, et al. (2002)
Cardiovasc Res 55, 76-82
 |  Abstract »  |  Full Text »  |  PDF »

A Post-Amadori Inhibitor Pyridoxamine Also Inhibits Chemical Modification of Proteins by Scavenging Carbonyl Intermediates of Carbohydrate and Lipid Degradation.

P. A. Voziyan, T. O. Metz, J. W. Baynes, and B. G. Hudson (2002)
J. Biol. Chem. 277, 3397-3403
 |  Abstract »  |  Full Text »  |  PDF »

Aminoguanidine and Aortic Wall Mechanics, Structure, and Composition in Aged Rats.

C. Cantini, P. Kieffer, B. Corman, P. Liminana, J. Atkinson, and I. Lartaud-Idjouadiene (2001)
Hypertension 38, 943-948
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Chronic Aminoguanidine Treatment on Age-Related Glycation, Glycoxidation, and Collagen Cross-linking in the Fischer 344 Rat.

D. R. Sell, J. F. Nelson, and V. M. Monnier (2001)
J. Gerontol. A Biol. Sci. Med. Sci. 56, B405-411
 |  Abstract »  |  Full Text »  |  PDF »

Glucose and Palmitic Acid Induce Degeneration of Myofibrils and Modulate Apoptosis in Rat Adult Cardiomyocytes.

D. Dyntar, M. Eppenberger-Eberhardt, K. Maedler, M. Pruschy, H. M. Eppenberger, G. A. Spinas, and M. Y. Donath (2001)
Diabetes 50, 2105-2113
 |  Abstract »  |  Full Text »  |  PDF »

Abnormalities of Retinal Metabolism in Diabetes and Experimental Galactosemia: VII. Effect of Long-Term Administration of Antioxidants on the Development of Retinopathy.

R. A. Kowluru, J. Tang, and T. S. Kern (2001)
Diabetes 50, 1938-1942
 |  Abstract »  |  Full Text »  |  PDF »

The Diabetic Foot : Basic Mechanisms of Disease.

G. P. Guyton and C. L. Saltzman (2001)
J. Bone Joint Surg. Am. 83, 1083-1096
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Pharmacological Inhibition of Diabetic Retinopathy: Aminoguanidine and Aspirin.

T. S. Kern and R. L. Engerman (2001)
Diabetes 50, 1636-1642
 |  Abstract »  |  Full Text »  |  PDF »

Advanced glycation: an important pathological event in diabetic and age related ocular disease.

A. W STITT (2001)
Br. J. Ophthalmol. 85, 746-753
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Reduction in Myocardial Collagen Cross-Linking Parallels Left Ventricular Dilatation in Rat Models of Systolic Chamber Dysfunction.

A. J. Woodiwiss, O. J. Tsotetsi, S. Sprott, E. J. Lancaster, T. Mela, E. S. Chung, T. E. Meyer, and G. R. Norton (2001)
Circulation 103, 155-160
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of the Inhibitory Effect of OPB-9195 [({+/-})-2-Isopropylidenehydrazono-4-oxo-thiazolidin-5-ylacetanilide] on Advanced Glycation End Product and Advanced Lipoxidation End Product Formation.

T. MIYATA, Y. UEDA, K. ASAHI, Y. IZUHARA, R. INAGI, A. SAITO, C. VAN YPERSELE DE STRIHOU, and K. KUROKAWA (2000)
J. Am. Soc. Nephrol. 11, 1719-1725
 |  Abstract »  |  Full Text »

Advanced Glycation and Lipoxidation End Products: Role of Reactive Carbonyl Compounds Generated during Carbohydrate and Lipid Metabolism.

T. MIYATA, K. KUROKAWA, and C. VAN YPERSELE DE STRIHOU (2000)
J. Am. Soc. Nephrol. 11, 1744-1752
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Food Restriction Prevents Advanced Glycation End Product Accumulation and Retards Kidney Aging in Lean Rats.

L. TEILLET, P. VERBEKE, S. GOURAUD, H. BAKALA, C. BOROT-LALOI, D. HEUDES, P. BRUNEVAL, and B. CORMAN (2000)
J. Am. Soc. Nephrol. 11, 1488-1497
 |  Abstract »  |  Full Text »

Molecular basis for a link between complement and the vascular complications of diabetes.

J. Acosta, J. Hettinga, R. Fluckiger, N. Krumrei, A. Goldfine, L. Angarita, and J. Halperin (2000)
PNAS 97, 5450-5455
 |  Abstract »  |  Full Text »  |  PDF »

Treatment of Diabetic Retinopathy.

F. L. Ferris, M. D. Davis, and L. M. Aiello (1999)
N. Engl. J. Med. 341, 667-678
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Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma.

A. H. Neufeld, A. Sawada, and B. Becker (1999)
PNAS 96, 9944-9948
 |  Abstract »  |  Full Text »  |  PDF »

Immunohistochemical Evidence for an Increased Oxidative Stress and Carbonyl Modification of Proteins in Diabetic Glomerular Lesions.

D. SUZUKI, T. MIYATA, N. SAOTOME, K. HORIE, R. INAGI, Y. YASUDA, K. UCHIDA, Y. IZUHARA, M. YAGAME, H. SAKAI, et al. (1999)
J. Am. Soc. Nephrol. 10, 822-832
 |  Abstract »  |  Full Text »

Age-Induced Protein Modifications and Increased Proteolysis in Potato Seed-Tubers.

G.N. M. Kumar, R. L. Houtz, and N. R. Knowles (1999)
Plant Physiology 119, 89-100
 |  Abstract »  |  Full Text »

Metabolic Delivery of Ketone Groups to Sialic Acid Residues. APPLICATION TO CELL SURFACE GLYCOFORM ENGINEERING.

K. J. Yarema, L. K. Mahal, R. E. Bruehl, E. C. Rodriguez, and C. R. Bertozzi (1998)
J. Biol. Chem. 273, 31168-31179
 |  Abstract »  |  Full Text »  |  PDF »

Influence of Glycation on LDL-Induced Generation of Fibrinolytic Regulators in Vascular Endothelial Cells.

J. Zhang, S. Ren, D. Sun, and G. X. Shen (1998)
Arterioscler. Thromb. Vasc. Biol. 18, 1140-1148
 |  Abstract »  |  Full Text »  |  PDF »

Epitopes close to the apolipoprotein B low density lipoprotein receptor-binding site are modified by advanced glycation end products.

X. Wang, R. Bucala, and R. Milne (1998)
PNAS 95, 7643-7647
 |  Abstract »  |  Full Text »  |  PDF »

Breakers of advanced glycation end products restore large artery properties in experimental diabetes.

B. H. R. Wolffenbuttel, C. M. Boulanger, F. R. L. Crijns, M. S. P. Huijberts, P. Poitevin, G. N. M. Swennen, S. Vasan, J. J. Egan, P. Ulrich, A. Cerami, et al. (1998)
PNAS 95, 4630-4634
 |  Abstract »  |  Full Text »  |  PDF »

AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept.

A. Bierhaus, M. A Hofmann, R. Ziegler, and P. P Nawroth (1998)
Cardiovasc Res 37, 586-600
 |  Abstract »  |  Full Text »  |  PDF »

Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy.

B. Corman, M. Duriez, P. Poitevin, D. Heudes, P. Bruneval, A. Tedgui, and B. I. Levy (1998)
PNAS 95, 1301-1306
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Metformin on Collagen Glycation and Diastolic Dysfunction in Diabetic Myocardium.

G.N. Jyothirmayi, B.J. Soni, M. Masurekar, M. Lyons, and T.J. Regan (1998)
Journal of Cardiovascular Pharmacology and Therapeutics 3, 319-326
 |  Abstract »  |  PDF »

TNF-alpha causes reversible in vivo systemic vascular barrier dysfunction via NO-dependent and -independent mechanisms.

N. K. Worrall, K. Chang, W. S. Lejeune, T. P. Misko, P. M. Sullivan, T. B. Ferguson Jr., and J. R. Williamson (1997)
Am J Physiol Heart Circ Physiol 273, H2565-H2574
 |  Abstract »  |  Full Text »  |  PDF »

Myocardial Stiffness Is Attributed to Alterations in Cross-Linked Collagen Rather Than Total Collagen or Phenotypes in Spontaneously Hypertensive Rats.

G. R. Norton, J. Tsotetsi, B. Trifunovic, C. Hartford, G. P. Candy, and A. J. Woodiwiss (1997)
Circulation 96, 1991-1998
 |  Abstract »  |  Full Text »

Inhibitory Effects of Tenilsetam on the Maillard Reaction.

H. Shoda, S. Miyata, B.-F. Liu, H. Yamada, T. Ohara, K. Suzuki, M. Oimomi, and M. Kasuga (1997)
Endocrinology 138, 1886-1892
 |  Abstract »  |  Full Text »  |  PDF »

In Vitro Kinetic Studies of Formation of Antigenic Advanced Glycation End Products (AGEs). NOVEL INHIBITION OF POST-AMADORI GLYCATION PATHWAYS.

A. A. Booth, R. G. Khalifah, P. Todd, and B. G. Hudson (1997)
J. Biol. Chem. 272, 5430-5437
 |  Abstract »  |  Full Text »  |  PDF »

Long Term Effects of Aminoguanidine on Insulin Release and Biosynthesis: Evidence That the Formation of Advanced Glycosylation End Products Inhibits B Cell Function.

Y. Tajiri, C. Moller, and V. Grill (1997)
Endocrinology 138, 273-280
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Inducible Nitric Oxide Synthase Attenuates Established Acute Cardiac Allograft Rejection.

N. K. Worrall, T. P. Misko, P. M. Sullivan, J.-J. Hui, and T. B. Ferguson Jr (1996)
Ann. Thorac. Surg. 62, 378-385
 |  Abstract »  |  Full Text »

Involvement of Hydrogen Peroxide in Collagen Cross-linking by High Glucose in Vitro and in Vivo.

A. Elgawish, M. Glomb, M. Friedlander, and V. M. Monnier (1996)
J. Biol. Chem. 271, 12964-12971
 |  Abstract »  |  Full Text »  |  PDF »

Aminoguanidine Prevents the Decreased Myocardial Compliance Produced by Streptozotocin-Induced Diabetes Mellitus in Rats.

G. R. Norton, G. Candy, and A. J. Woodiwiss (1996)
Circulation 93, 1905-1912
 |  Abstract »  |  Full Text »

Inhibition of Inducible Nitric Oxide Synthase Prevents Myocardial and Systemic Vascular Barrier Dysfunction During Early Cardiac Allograft Rejection.

N. K. Worrall, K. Chang, G. M. Suau, W. S. Allison, T. P. Misko, P. M. Sullivan, R. G. Tilton, J. R. Williamson, and T. B. Ferguson Jr (1996)
Circ. Res. 78, 769-779
 |  Abstract »  |  Full Text »

The Advanced Glycation End Product, N[IMAGE]-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions.

M.-X. Fu, J.ús R. Requena, A. J. Jenkins, T. J. Lyons, J. W. Baynes, and S. R. Thorpe (1996)
J. Biol. Chem. 271, 9982-9986
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of Protein Modification by Glyoxal and Glycolaldehyde, Reactive Intermediates of the Maillard Reaction.

M. A. Glomb and V. M. Monnier (1995)
J. Biol. Chem. 270, 10017-10026
 |  Abstract »  |  Full Text »  |  PDF »

Aminoguanidine Has Both Pro-oxidant and Antioxidant Activity Toward LDL.

A. Philis-Tsimikas, S. Parthasarathy, S. Picard, W. Palinski, and J. L. Witztum (1995)
Arterioscler. Thromb. Vasc. Biol. 15, 367-376
 |  Abstract »  |  Full Text »

Matrix Nonenzymatic Glycosylation Leads to Altered Cellular Phenotype and Intracellular Tyrosine Phosphorylation.

G. Hasegawa, A. J. Hunter, and A. S. Charonis (1995)
J. Biol. Chem. 270, 3278-3283
 |  Abstract »  |  Full Text »  |  PDF »

Novel Degradation Pathway of Glycated Amino Acids into Free Fructosamine by a Pseudomonas sp. Soil Strain Extract.

C. Gerhardinger, M. S. Marion, A. Rovner, M. Glomb, and V. M. Monnier (1995)
J. Biol. Chem. 270, 218-224
 |  Abstract »  |  Full Text »  |  PDF »

Hemoglobin-AGE: a circulating marker of advanced glycosylation.

Z Makita, H Vlassara, E Rayfield, K Cartwright, E Friedman, R Rodby, A Cerami, and R Bucala (1992)
Science 258, 651-653
 |  Abstract »  |  PDF »

Chelating Activity of Advanced Glycation End-product Inhibitors.

D. L. Price, P. M. Rhett, S. R. Thorpe, and J. W. Baynes (2001)
J. Biol. Chem. 276, 48967-48972
 |  Abstract »  |  Full Text »  |  PDF »

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