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Science 20 June 1986:
Vol. 232. no. 4757, pp. 1540 - 1543
DOI: 10.1126/science.3715461
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Articles
Science, Vol 232, Issue 4757, 1540-1543
Copyright © 1986 by American Association for the Advancement of Science
Estrogen-induced factors of breast cancer cells partially replace estrogen to promote tumor growth
RB Dickson,
ME McManaway,
and
ME Lippman
The hormone 17 beta-estradiol acts through its receptor system to induce MCF-7 human breast cancer cells to form tumors in athymic mice. In vitro studies have identified the production of estrogen-induced growth factors from MCF-7 cells that may have a role in growth control. These induced growth factors were sufficient to stimulate MCF-7 tumor growth in ovariectomized athymic mice, thus partially replacing estradiol. Growth factors may act as estrogen-induced "second messengers" in estrogen-responsive growth of human breast cancer.
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