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Science 6 June 1986:
Vol. 232. no. 4755, pp. 1255 - 1258
DOI: 10.1126/science.3704650
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Articles

Science, Vol 232, Issue 4755, 1255-1258
Copyright © 1986 by American Association for the Advancement of Science

articles

Non-Watson-Crick G.C and A.T base pairs in a DNA-antibiotic complex

GJ Quigley, G Ughetto, GA van der Marel, JH van Boom, AH Wang, and A Rich

The structure of a DNA octamer d(GCGTACGC) cocrystallized with the bisintercalator antibiotic triostin A has been solved. The DNA forms an unwound right-handed double helix. Four base pairs are of the Watson-Crick type while four are Hoogsteen base pairs, including two A.T and two G.C base pairs. This is the first observation in an oligonucleotide of Hoogsteen G.C base pairs where the cystosine is protonated. It is likely that these also occur in solutions of DNA complexed to this antibiotic.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Echinomycin inhibits chromosomal DNA replication and embryonic development in vertebrates.
L. G. May, M. A. Madine, and M. J. Waring (2004)
Nucleic Acids Res. 32, 65-72
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Facilitating structural transitions in DNA.
M. Waring (2000)
PNAS 97, 11685-11687
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