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Science 23 May 1986:
Vol. 232. no. 4753, pp. 991 - 993
DOI: 10.1126/science.3010460
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Articles

Science, Vol 232, Issue 4753, 991-993
Copyright © 1986 by American Association for the Advancement of Science

articles

Coronavirus infection induces H-2 antigen expression on oligodendrocytes and astrocytes

A Suzumura, E Lavi, Weiss SR, and DH Silberberg

Infection of the central nervous system by mouse hepatitis virus strain A59, a murine neurotropic coronavirus, induces class I major histocompatibility complex antigens on mouse oligodendrocytes and astrocytes, cells that do not normally express these antigens on their surfaces. This induction, which occurs through soluble factors elaborated by infected glial cells, potentially allows immunocytes to interact with the glial cells and may play a critical role in the pathogenesis of virus-induced, immune-mediated demyelination in the central nervous system.


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